| # | Title | Journal | Year | Citations |
|---|
| 1 | A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial | Lancet, The | 2015 | 2,307 |
| 2 | Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study | BMJ: British Medical Journal | 2001 | 1,298 |
| 3 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 4 | ILAE Treatment Guidelines: Evidence-based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes | Epilepsia | 2006 | 782 |
| 5 | Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes | Epilepsia | 2013 | 599 |
| 6 | Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy | Lancet Neurology, The | 2002 | 563 |
| 7 | Hippocampus and entorhinal cortex in mild cognitive impairment and early AD | Neurobiology of Aging | 2004 | 539 |
| 8 | Mechanisms of epileptogenesis and potential treatment targets | Lancet Neurology, The | 2011 | 490 |
| 9 | Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study | BMJ: British Medical Journal | 1997 | 388 |
| 10 | The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress | Alzheimer's and Dementia | 2013 | 385 |
| 11 | Clinical picture of EPM1‐Unverricht‐Lundborg disease | Epilepsia | 2008 | 367 |
| 12 | The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers | Alzheimer's and Dementia | 2011 | 354 |
| 13 | A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats | Neuroscience | 2006 | 317 |
| 14 | Increased fMRI responses during encoding in mild cognitive impairment | Neurobiology of Aging | 2007 | 298 |
| 15 | MRI of the Hippocampus in Alzheimer’s Disease: Sensitivity, Specificity, and Analysis of the Incorrectly Classified Subjects | Neurobiology of Aging | 1998 | 285 |
| 16 | BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study | Neurobiology of Learning and Memory | 2008 | 282 |
| 17 | Slowing of EEG in Parkinson's disease | Electroencephalography and Clinical Neurophysiology | 1991 | 281 |
| 18 | Incidence and Risk Factors for Mild Cognitive Impairment: A Population-Based Three-Year Follow-Up Study of Cognitively Healthy Elderly Subjects | Dementia and Geriatric Cognitive Disorders | 2004 | 248 |
| 19 | Multi-Method Analysis of MRI Images in Early Diagnostics of Alzheimer's Disease | PLoS ONE | 2011 | 240 |
| 20 | Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial | Alzheimer's and Dementia | 2018 | 236 |
| 21 | Recurrent seizures may cause hippocambal damage in temporal lobe epilepsy | Neurology | 1998 | 225 |
| 22 | Amyloid β protein 1–40 and 1–42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease | Neuroscience Letters | 2001 | 223 |
| 23 | Identification of new epilepsy treatments: Issues in preclinical methodology | Epilepsia | 2012 | 219 |
| 24 | Valproate in the treatment of epilepsy in girls and women of childbearing potential | Epilepsia | 2015 | 212 |
| 25 | Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study | Biological Psychiatry | 2000 | 210 |
| 26 | Amygdala damage in experimental and human temporal lobe epilepsy | Epilepsy Research | 1998 | 205 |
| 27 | A voxel based morphometry study on mild cognitive impairment | Journal of Neurology, Neurosurgery and Psychiatry | 2005 | 196 |
| 28 | Verbal fluency activates the left medial temporal lobe: A functional magnetic resonance imaging study | Annals of Neurology | 2000 | 195 |
| 29 | Tiagabine in the treatment of epilepsy — a clinical review with a guide for the prescribing physician | Epilepsy Research | 2000 | 195 |
| 30 | Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy | Progress in Brain Research | 2002 | 182 |
| 31 | Psychopathy and the posterior hippocampus | Behavioural Brain Research | 2001 | 181 |
| 32 | Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease | International Journal of Geriatric Psychiatry | 2011 | 175 |
| 33 | Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance | Diabetes Care | 1998 | 171 |
| 34 | Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes | Neuroscience | 1995 | 164 |
| 35 | A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease | Journal of Magnetic Resonance Imaging | 2004 | 163 |
| 36 | Status Epilepticus Causes Necrotic Damage in the Mediodorsal Nucleus of the Thalamus in Immature Rats | Journal of Neuroscience | 2001 | 156 |
| 37 | Remodeling of neuronal circuitries in human temporal lobe epilepsy: Increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex | Annals of Neurology | 1998 | 155 |
| 38 | A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism | Behavioural Brain Research | 2000 | 152 |
| 39 | Amyloid‐β oligomers set fire to inflammasomes and induce Alzheimer's pathology | Journal of Cellular and Molecular Medicine | 2008 | 149 |
| 40 | Education increases reserve against Alzheimer’s disease—evidence from structural MRI analysis | Neuroradiology | 2012 | 148 |
| 41 | Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers | Annals of Neurology | 2005 | 144 |
| 42 | Brain anatomy of persistent violent offenders: More rather than less | Psychiatry Research - Neuroimaging | 2008 | 142 |
| 43 | Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans | European Journal of Neuroscience | 2004 | 140 |
| 44 | Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment | NeuroImage | 2007 | 136 |
| 45 | Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention | JAMA Neurology | 2018 | 136 |
| 46 | Progression of Brain Damage after Status Epilepticus and Its Association with Epileptogenesis: A Quantitative MRI Study in a Rat Model of Temporal Lobe Epilepsy | Epilepsia | 2004 | 132 |
| 47 | Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ϵ4 allele | Neurology | 1995 | 126 |
| 48 | Frontotemporal dementia as a neural system disease | Neurobiology of Aging | 2005 | 126 |
| 49 | Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe | Journal of Epidemiology and Community Health | 2002 | 119 |
| 50 | Long-Term Efficacy and Safety of Celecoxib in Alzheimer’s Disease | Dementia and Geriatric Cognitive Disorders | 2007 | 119 |
