# | Title | Journal | Year | Citations |
---|
1 | Molecular and cellular mechanisms of general anaesthesia | Nature | 1994 | 1,738 |
2 | Structural Basis of the Drug-binding Specificity of Human Serum Albumin | Journal of Molecular Biology | 2005 | 1,617 |
3 | Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin 1 1Edited by R. Huber | Journal of Molecular Biology | 2000 | 813 |
4 | Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S | EMBO Journal | 1997 | 619 |
5 | Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes | Structure | 1996 | 594 |
6 | Do general anaesthetics act by competitive binding to specific receptors? | Nature | 1984 | 545 |
7 | Molecular mechanisms of general anaesthesia | Nature | 1982 | 431 |
8 | Mammalian collagen receptors | Matrix Biology | 2007 | 353 |
9 | Molecular targets underlying general anaesthesia | British Journal of Pharmacology | 2006 | 314 |
10 | Two-Pore-Domain K+ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane | Molecular Pharmacology | 2004 | 294 |
11 | Lessons from the Crystallographic Analysis of Small Molecule Binding to Human Serum Albumin | Drug Metabolism and Pharmacokinetics | 2009 | 247 |
12 | Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα | Journal of Molecular Biology | 2008 | 241 |
13 | Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects | Nature | 1985 | 237 |
14 | The Crystal Structure of a Laminin G–like Module Reveals the Molecular Basis of α-Dystroglycan Binding to Laminins, Perlecan, and Agrin | Molecular Cell | 1999 | 230 |
15 | Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 224 |
16 | Zinc and copper: Pharmacological probes and endogenous modulators of neuronal excitability | | 2006 | 213 |
17 | A new look at thin filament regulation in vertebrate skeletal muscle | FASEB Journal | 1998 | 210 |
18 | Volatile general anaesthetics activate a novel neuronal K+ current | Nature | 1988 | 199 |
19 | The TREK K2P channels and their role in general anaesthesia and neuroprotection | Trends in Pharmacological Sciences | 2004 | 196 |
20 | Architecture and function in the muscle sarcomere | Current Opinion in Structural Biology | 1997 | 191 |
21 | Three-dimensional crystallization of membrane proteins | Quarterly Reviews of Biophysics | 1988 | 182 |
22 | A method for monitoring the collapse of plastic sections as a function of electron dose | Ultramicroscopy | 1988 | 177 |
23 | The relationship between the locations of spatial features and those of fixations made during visual examination of briefly presented images | Spatial Vision | 1996 | 176 |
24 | Domain structure and organisation in extracellular matrix proteins | Matrix Biology | 2002 | 175 |
25 | Structure of the C-terminal laminin G-like domain pair of the laminin alpha 2 chain harbouring binding sites for alpha -dystroglycan and heparin | EMBO Journal | 2000 | 172 |
26 | Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine | British Journal of Pharmacology | 2005 | 167 |
27 | Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors | Journal of Physiology | 2007 | 150 |
28 | The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury* | Critical Care Medicine | 2008 | 150 |
29 | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein | Nature Structural and Molecular Biology | 2004 | 128 |
30 | Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease | Journal of Biological Chemistry | 2005 | 126 |
31 | The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAAReceptor β3N265M Knock-In Mouse | Journal of Neuroscience | 2009 | 123 |
32 | Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin | Journal of Structural Biology | 2011 | 121 |
33 | Determination of the aggregate size in detergent solution of the light-harvesting chlorophyll a/b-protein complex from chloroplast membranes | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 119 |
34 | Mechanisms of general anesthesia. | Environmental Health Perspectives | 1990 | 119 |
35 | The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction | FEBS Journal | 1984 | 110 |
36 | Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer | Structure | 2002 | 108 |
37 | Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N-Methyl-d-Aspartate Receptor Glycine Site | Anesthesiology | 2013 | 105 |
38 | Synaptic Release Generates a Tonic GABAA Receptor-Mediated Conductance That Modulates Burst Precision in Thalamic Relay Neurons | Journal of Neuroscience | 2007 | 104 |
39 | Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin I | Structure | 2003 | 102 |
40 | Non-stokesian nature of transverse diffusion within human red cell membranes | Journal of Membrane Biology | 1986 | 100 |
41 | Is membrane expansion relevant to anaesthesia? | Nature | 1981 | 98 |
42 | Molecular Organization of Liquid n-Octanol: An X-ray Diffraction Analysis | Journal of Pharmaceutical Sciences | 1993 | 97 |
43 | Structure of the C-Terminal Domain of Human La Protein Reveals a Novel RNA Recognition Motif Coupled to a Helical Nuclear Retention Element | Structure | 2003 | 96 |
44 | Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation | Journal of General Virology | 2005 | 95 |
45 | GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of Consciousness | Journal of Neuroscience | 2012 | 89 |
46 | Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection | Critical Care | 2010 | 87 |
47 | Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAAReceptors during Spillover | Journal of Neuroscience | 2011 | 87 |
48 | Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia | Anesthesiology | 2010 | 86 |
49 | LG/LNS domains: multiple functions – one business end? | Trends in Biochemical Sciences | 2001 | 85 |
50 | Neuronal Preconditioning by Inhalational Anesthetics | Anesthesiology | 2009 | 84 |