173(top 1%)
papers
16.3K(top 1%)
citations
61(top 1%)
h-index
126(top 1%)
g-index
179
all documents
16.9K
doc citations
2.4K
citing journals

Top Articles

#TitleJournalYearCitations
1Molecular and cellular mechanisms of general anaesthesiaNature19941,738
2Structural Basis of the Drug-binding Specificity of Human Serum AlbuminJournal of Molecular Biology20051,617
3Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin 1 1Edited by R. HuberJournal of Molecular Biology2000813
4Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin SEMBO Journal1997619
5Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymesStructure1996594
6Do general anaesthetics act by competitive binding to specific receptors?Nature1984545
7Molecular mechanisms of general anaesthesiaNature1982431
8Mammalian collagen receptorsMatrix Biology2007353
9Molecular targets underlying general anaesthesiaBritish Journal of Pharmacology2006314
10Two-Pore-Domain K+ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and CyclopropaneMolecular Pharmacology2004294
11Lessons from the Crystallographic Analysis of Small Molecule Binding to Human Serum AlbuminDrug Metabolism and Pharmacokinetics2009247
12Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXαJournal of Molecular Biology2008241
13Mapping of general anaesthetic target sites provides a molecular basis for cutoff effectsNature1985237
14The Crystal Structure of a Laminin G–like Module Reveals the Molecular Basis of α-Dystroglycan Binding to Laminins, Perlecan, and AgrinMolecular Cell1999230
15Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemiaProceedings of the National Academy of Sciences of the United States of America2003224
16Zinc and copper: Pharmacological probes and endogenous modulators of neuronal excitability2006213
17A new look at thin filament regulation in vertebrate skeletal muscleFASEB Journal1998210
18Volatile general anaesthetics activate a novel neuronal K+ currentNature1988199
19The TREK K2P channels and their role in general anaesthesia and neuroprotectionTrends in Pharmacological Sciences2004196
20Architecture and function in the muscle sarcomereCurrent Opinion in Structural Biology1997191
21Three-dimensional crystallization of membrane proteinsQuarterly Reviews of Biophysics1988182
22A method for monitoring the collapse of plastic sections as a function of electron doseUltramicroscopy1988177
23The relationship between the locations of spatial features and those of fixations made during visual examination of briefly presented imagesSpatial Vision1996176
24Domain structure and organisation in extracellular matrix proteinsMatrix Biology2002175
25Structure of the C-terminal laminin G-like domain pair of the laminin alpha 2 chain harbouring binding sites for alpha -dystroglycan and heparinEMBO Journal2000172
26Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetineBritish Journal of Pharmacology2005167
27Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptorsJournal of Physiology2007150
28The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury*Critical Care Medicine2008150
29Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La proteinNature Structural and Molecular Biology2004128
30Crystal Structure of Foot-and-Mouth Disease Virus 3C ProteaseJournal of Biological Chemistry2005126
31The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAAReceptor β3N265M Knock-In MouseJournal of Neuroscience2009123
32Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albuminJournal of Structural Biology2011121
33Determination of the aggregate size in detergent solution of the light-harvesting chlorophyll a/b-protein complex from chloroplast membranesProceedings of the National Academy of Sciences of the United States of America1988119
34Mechanisms of general anesthesia.Environmental Health Perspectives1990119
35The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interactionFEBS Journal1984110
36Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain TrimerStructure2002108
37Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N-Methyl-d-Aspartate Receptor Glycine SiteAnesthesiology2013105
38Synaptic Release Generates a Tonic GABAA Receptor-Mediated Conductance That Modulates Burst Precision in Thalamic Relay NeuronsJournal of Neuroscience2007104
39Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin IStructure2003102
40Non-stokesian nature of transverse diffusion within human red cell membranesJournal of Membrane Biology1986100
41Is membrane expansion relevant to anaesthesia?Nature198198
42Molecular Organization of Liquid n-Octanol: An X-ray Diffraction AnalysisJournal of Pharmaceutical Sciences199397
43Structure of the C-Terminal Domain of Human La Protein Reveals a Novel RNA Recognition Motif Coupled to a Helical Nuclear Retention ElementStructure200396
44Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variationJournal of General Virology200595
45GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of ConsciousnessJournal of Neuroscience201289
46Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotectionCritical Care201087
47Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAAReceptors during SpilloverJournal of Neuroscience201187
48Competitive Inhibition at the Glycine Site of the N -Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–IschemiaAnesthesiology201086
49LG/LNS domains: multiple functions – one business end?Trends in Biochemical Sciences200185
50Neuronal Preconditioning by Inhalational AnestheticsAnesthesiology200984