# | Title | Journal | Year | Citations |
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1 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,178 |
2 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,992 |
3 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,724 |
4 | Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol | Science | 2004 | 1,041 |
5 | Association analyses based on false discovery rate implicate new loci for coronary artery disease | Nature Genetics | 2017 | 597 |
6 | Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction | Nature | 2015 | 591 |
7 | A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium | Nature Genetics | 2009 | 490 |
8 | Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 2010 | 374 |
9 | Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease | Stroke | 2014 | 311 |
10 | Genetics of Coronary Artery Disease | Circulation Research | 2016 | 301 |
11 | Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease | Journal of the American College of Cardiology | 2017 | 222 |
12 | Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis | Lancet Neurology, The | 2017 | 202 |
13 | From The Cover: The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 172 |
14 | Genes and Coronary Artery Disease | Journal of the American College of Cardiology | 2012 | 139 |
15 | Gene Dosage of the Common Variant 9p21 Predicts Severity of Coronary Artery Disease | Journal of the American College of Cardiology | 2010 | 134 |
16 | Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease | PLoS Genetics | 2012 | 121 |
17 | Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease | Nature Communications | 2016 | 111 |
18 | The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential | Cardiovascular Diabetology | 2019 | 108 |
19 | Hepatic Lipase, High Density Lipoproteins, and Hypertriglyceridemia | American Journal of Pathology | 2011 | 101 |
20 | The Keap1–Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1 | Antioxidants and Redox Signaling | 2017 | 96 |
21 | In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients | Journal of Medical Genetics | 2005 | 91 |
22 | Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies | European Heart Journal | 2012 | 90 |
23 | Improved Prediction of Cardiovascular Disease Based on a Panel of Single Nucleotide Polymorphisms Identified Through Genome-Wide Association Studies | Circulation: Cardiovascular Genetics | 2010 | 88 |
24 | Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study | Lancet Diabetes and Endocrinology,the | 2017 | 88 |
25 | Plasma PCSK9 Levels Are Elevated with Acute Myocardial Infarction in Two Independent Retrospective Angiographic Studies | PLoS ONE | 2014 | 79 |
26 | Functional interaction between COL4A1/COL4A2 and SMAD3 risk loci for coronary artery disease | Atherosclerosis | 2015 | 57 |
27 | Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes | Cardiovascular Research | 2019 | 56 |
28 | Clinical and Genetic Association of Serum Ceruloplasmin With Cardiovascular Risk | Arteriosclerosis, Thrombosis, and Vascular Biology | 2012 | 55 |
29 | 9p21 and the Genetic Revolution for Coronary Artery Disease | Clinical Chemistry | 2012 | 54 |
30 | Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 2016 | 49 |
31 | 9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor–Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells | Circulation | 2015 | 48 |
32 | Obesity shows preserved plasma proteome in large independent clinical cohorts | Scientific Reports | 2018 | 47 |
33 | Genome-Wide Association Studies of Hypertension: Have They Been Fruitful? | Journal of Cardiovascular Translational Research | 2010 | 46 |
34 | Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 44 |
35 | Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes | Diabetologia | 2005 | 41 |
36 | SPG7 Variant Escapes Phosphorylation-Regulated Processing by AFG3L2, Elevates Mitochondrial ROS, and Is Associated with Multiple Clinical Phenotypes | Cell Reports | 2014 | 40 |
37 | Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion? | Current Cardiology Reports | 2014 | 40 |
38 | Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages | American Journal of Human Genetics | 2015 | 38 |
39 | Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice | Physiological Reports | 2014 | 35 |
40 | A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study | Pharmacogenomics Journal | 2016 | 35 |
41 | Adiposity significantly modifies genetic risk for dyslipidemia | Journal of Lipid Research | 2014 | 33 |
42 | A genetic basis for coronary artery disease | Trends in Cardiovascular Medicine | 2015 | 33 |
43 | Gene–environment interaction in dyslipidemia | Current Opinion in Lipidology | 2015 | 33 |
44 | Partitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity | Cardiovascular Research | 2017 | 31 |
45 | Extracellular Nucleotides Inhibit Insulin Receptor Signaling, Stimulate Autophagy and Control Lipoprotein Secretion | PLoS ONE | 2012 | 27 |
46 | Increased genetic risk for obesity in premature coronary artery disease | European Journal of Human Genetics | 2016 | 27 |
47 | Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1 | Atherosclerosis | 2019 | 27 |
48 | Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet‐induced weight loss | FASEB Journal | 2009 | 26 |
49 | Two Chromosome 9p21 Haplotype Blocks Distinguish Between Coronary Artery Disease and Myocardial Infarction Risk | Circulation: Cardiovascular Genetics | 2013 | 26 |
50 | Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk | Atherosclerosis | 2015 | 26 |