| # | Title | Journal | Year | Citations |
|---|
| 1 | Sequence and organization of the human mitochondrial genome | Nature | 1981 | 8,950 |
| 2 | Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis | Cell | 1996 | 6,230 |
| 3 | MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy | Nature Methods | 2017 | 6,166 |
| 4 | The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation | Science | 2011 | 4,768 |
| 5 | Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis | Nature Cell Biology | 2000 | 2,487 |
| 6 | The genetics of ageing | Nature | 2010 | 2,398 |
| 7 | Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes | Nature | 1985 | 2,312 |
| 8 | MICROTUBULE POLYMERIZATION DYNAMICS | Annual Review of Cell and Developmental Biology | 1997 | 2,222 |
| 9 | Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation | Cell | 2014 | 2,176 |
| 10 | Size and charge isomer separation and estimation of molecular weights of proteins by disc gel electrophoresis | Archives of Biochemistry and Biophysics | 1968 | 2,101 |
| 11 | Structural design and molecular evolution of a cytokine receptor superfamily. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 2,043 |
| 12 | Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes | Cell | 1980 | 2,005 |
| 13 | Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans | Nature | 2003 | 1,998 |
| 14 | Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks | Annual Review of Genetics | 1985 | 1,939 |
| 15 | Switching and Signaling at the Telomere | Cell | 2001 | 1,907 |
| 16 | Induction of angiogenesis during the transition from hyperplasia to neoplasia | Nature | 1989 | 1,782 |
| 17 | Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM | Nature Methods | 2013 | 1,707 |
| 18 | Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System | Cell | 2013 | 1,695 |
| 19 | The Transcriptional Program of Sporulation in Budding Yeast | Cell | 1998 | 1,634 |
| 20 | Whole-genome analyses resolve early branches in the tree of life of modern birds | Science | 2014 | 1,583 |
| 21 | Comparative Genomics of the Eukaryotes | Science | 2000 | 1,573 |
| 22 | The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins | Science | 2002 | 1,539 |
| 23 | Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA | Nature | 1991 | 1,517 |
| 24 | Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors | Cancer Cell | 2005 | 1,478 |
| 25 | Structure of the TRPV1 ion channel determined by electron cryo-microscopy | Nature | 2013 | 1,451 |
| 26 | The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum | PLoS Biology | 2003 | 1,433 |
| 27 | daf-16: An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans | Science | 1997 | 1,429 |
| 28 | Three-Dimensional Resolution Doubling in Wide-Field Fluorescence Microscopy by Structured Illumination | Biophysical Journal | 2008 | 1,372 |
| 29 | Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin | Nature | 2017 | 1,351 |
| 30 | Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor | Science | 2003 | 1,346 |
| 31 | Transcription factor interactions: selectors of positive or negative regulation from a single DNA element | Science | 1990 | 1,332 |
| 32 | Vertebrate Smoothened functions at the primary cilium | Nature | 2005 | 1,317 |
| 33 | Predicting Splicing from Primary Sequence with Deep Learning | Cell | 2019 | 1,305 |
| 34 | Rat insulin genes: construction of plasmids containing the coding sequences | Science | 1977 | 1,295 |
| 35 | Beyond self-assembly: From microtubules to morphogenesis | Cell | 1986 | 1,279 |
| 36 | Lipid Droplets and Cellular Lipid Metabolism | Annual Review of Biochemistry | 2012 | 1,264 |
| 37 | Cyclin synthesis drives the early embryonic cell cycle | Nature | 1989 | 1,236 |
| 38 | The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists | Cell | 1998 | 1,235 |
| 39 | The Plasticity of Aging: Insights from Long-Lived Mutants | Cell | 2005 | 1,216 |
| 40 | Functional inactivation of genes by dominant negative mutations | Nature | 1987 | 1,212 |
| 41 | Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose | Cell | 1986 | 1,189 |
| 42 | Eight prion strains have PrPSc molecules with different conformations | Nature Medicine | 1998 | 1,178 |
| 43 | Circular dichroic analysis of protein conformation: Inclusion of the β-turns | Analytical Biochemistry | 1978 | 1,145 |
| 44 | The role of cyclin synthesis and degradation in the control of maturation promoting factor activity | Nature | 1989 | 1,141 |
| 45 | Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection | Science | 2015 | 1,135 |
| 46 | Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos | Cell | 1991 | 1,102 |
| 47 | Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Cell | 1993 | 1,101 |
| 48 | Pathways of protein secretion in eukaryotes | Science | 1985 | 1,078 |
| 49 | Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance | Cell | 1999 | 1,067 |
| 50 | Expression of engrailed proteins in arthropods, annelids, and chordates | Cell | 1989 | 1,048 |
