| # | Title | Journal | Year | Citations |
|---|
| 1 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity | Science | 2012 | 12,811 |
| 2 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 3 | Short-Term Synaptic Plasticity | Annual Review of Physiology | 2002 | 3,888 |
| 4 | Molecular Basis of Bacterial Outer Membrane Permeability Revisited | Microbiology and Molecular Biology Reviews | 2003 | 3,359 |
| 5 | The Free Radical Theory of Aging Matures | Physiological Reviews | 1998 | 3,323 |
| 6 | Enhancement of Antitumor Immunity by CTLA-4 Blockade | Science | 1996 | 3,231 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 8 | The Molecular Biology of Axon Guidance | Science | 1996 | 3,094 |
| 9 | Cellular and Molecular Mechanisms of Pain | Cell | 2009 | 3,090 |
| 10 | The Ubiquitin Code | Annual Review of Biochemistry | 2012 | 2,844 |
| 11 | Synaptic Activity and the Construction of Cortical Circuits | Science | 1996 | 2,745 |
| 12 | CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity | Science | 2018 | 2,355 |
| 13 | Innate or Adaptive Immunity? The Example of Natural Killer Cells | Science | 2011 | 2,234 |
| 14 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA | Nature | 2000 | 2,167 |
| 15 | CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. | Journal of Experimental Medicine | 1995 | 1,922 |
| 16 | The Evolution and Future of Earth’s Nitrogen Cycle | Science | 2010 | 1,912 |
| 17 | RNA-programmed genome editing in human cells | ELife | 2013 | 1,830 |
| 18 | Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos | Methods in Cell Biology | 1991 | 1,775 |
| 19 | The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis | Nature | 2019 | 1,756 |
| 20 | Alpha-lipoic acid as a biological antioxidant | Free Radical Biology and Medicine | 1995 | 1,709 |
| 21 | Neurotrophins as synaptic modulators | Nature Reviews Neuroscience | 2001 | 1,594 |
| 22 | Comparative Genomics of the Eukaryotes | Science | 2000 | 1,573 |
| 23 | Normalization of RNA-seq data using factor analysis of control genes or samples | Nature Biotechnology | 2014 | 1,570 |
| 24 | Neurotrophin regulation of neural circuit development and function | Nature Reviews Neuroscience | 2013 | 1,564 |
| 25 | Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics | BMC Genomics | 2018 | 1,562 |
| 26 | CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones | Nature | 1992 | 1,516 |
| 27 | The amphioxus genome and the evolution of the chordate karyotype | Nature | 2008 | 1,496 |
| 28 | The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 | Cell | 1996 | 1,479 |
| 29 | Phase separation drives heterochromatin domain formation | Nature | 2017 | 1,456 |
| 30 | Prevention of drug access to bacterial targets: permeability barriers and active efflux | Science | 1994 | 1,451 |
| 31 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 32 | The developmental transcriptome of Drosophila melanogaster | Nature | 2011 | 1,379 |
| 33 | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor | Cell | 2006 | 1,358 |
| 34 | Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain | Neuron | 2014 | 1,350 |
| 35 | High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity | Nature Biotechnology | 2013 | 1,303 |
| 36 | CRISPR–Cas9 Structures and Mechanisms | Annual Review of Biophysics | 2017 | 1,289 |
| 37 | Multidrug Resistance in Bacteria | Annual Review of Biochemistry | 2009 | 1,227 |
| 38 | COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum | Cell | 1994 | 1,225 |
| 39 | The complete sequence of a human genome | Science | 2022 | 1,222 |
| 40 | Ten years of tension: single-molecule DNA mechanics | Nature | 2003 | 1,203 |
| 41 | The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor | Nature | 2005 | 1,168 |
| 42 | Roles of the NKG2D immunoreceptor and its ligands | Nature Reviews Immunology | 2003 | 1,161 |
| 43 | Transcriptional activation: A complex puzzle with few easy pieces | Cell | 1994 | 1,155 |
| 44 | Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells | Science | 1993 | 1,128 |
| 45 | A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival | Immunity | 2001 | 1,124 |
| 46 | Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE | Science | 2010 | 1,124 |
| 47 | Transcription regulation and animal diversity | Nature | 2003 | 1,109 |
| 48 | The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria | Clinical Microbiology Reviews | 2015 | 1,097 |
| 49 | Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos | Cell | 1992 | 1,093 |
| 50 | Mechanism of transcriptional activation by Sp1: Evidence for coactivators | Cell | 1990 | 1,088 |
