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1A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial ImmunityScience201212,811
2The Genome Sequence of Drosophila melanogasterScience20005,566
3Short-Term Synaptic PlasticityAnnual Review of Physiology20023,888
4Molecular Basis of Bacterial Outer Membrane Permeability RevisitedMicrobiology and Molecular Biology Reviews20033,359
5The Free Radical Theory of Aging MaturesPhysiological Reviews19983,323
6Enhancement of Antitumor Immunity by CTLA-4 BlockadeScience19963,231
7Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,122
8The Molecular Biology of Axon GuidanceScience19963,094
9Cellular and Molecular Mechanisms of PainCell20093,090
10The Ubiquitin CodeAnnual Review of Biochemistry20122,844
11Synaptic Activity and the Construction of Cortical CircuitsScience19962,745
12CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activityScience20182,355
13Innate or Adaptive Immunity? The Example of Natural Killer CellsScience20112,234
14Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNANature20002,167
15CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.Journal of Experimental Medicine19951,922
16The Evolution and Future of Earth’s Nitrogen CycleScience20101,912
17RNA-programmed genome editing in human cellsELife20131,830
18Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus EmbryosMethods in Cell Biology19911,775
19The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosisNature20191,756
20Alpha-lipoic acid as a biological antioxidantFree Radical Biology and Medicine19951,709
21Neurotrophins as synaptic modulatorsNature Reviews Neuroscience20011,594
22Comparative Genomics of the EukaryotesScience20001,573
23Normalization of RNA-seq data using factor analysis of control genes or samplesNature Biotechnology20141,570
24Neurotrophin regulation of neural circuit development and functionNature Reviews Neuroscience20131,564
25Slingshot: cell lineage and pseudotime inference for single-cell transcriptomicsBMC Genomics20181,562
26CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clonesNature19921,516
27The amphioxus genome and the evolution of the chordate karyotypeNature20081,496
28The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4Cell19961,479
29Phase separation drives heterochromatin domain formationNature20171,456
30Prevention of drug access to bacterial targets: permeability barriers and active effluxScience19941,451
31Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20211,430
32The developmental transcriptome of Drosophila melanogasterNature20111,379
33An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor ReceptorCell20061,358
34Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult BrainNeuron20141,350
35High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificityNature Biotechnology20131,303
36CRISPR–Cas9 Structures and MechanismsAnnual Review of Biophysics20171,289
37Multidrug Resistance in BacteriaAnnual Review of Biochemistry20091,227
38COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulumCell19941,225
39The complete sequence of a human genomeScience20221,222
40Ten years of tension: single-molecule DNA mechanicsNature20031,203
41The DNA damage pathway regulates innate immune system ligands of the NKG2D receptorNature20051,168
42Roles of the NKG2D immunoreceptor and its ligandsNature Reviews Immunology20031,161
43Transcriptional activation: A complex puzzle with few easy piecesCell19941,155
44Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cellsScience19931,128
45A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and SurvivalImmunity20011,124
46Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODEScience20101,124
47Transcription regulation and animal diversityNature20031,109
48The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative BacteriaClinical Microbiology Reviews20151,097
49Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryosCell19921,093
50Mechanism of transcriptional activation by Sp1: Evidence for coactivatorsCell19901,088