| # | Title | Journal | Year | Citations |
|---|
| 1 | Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. | Proceedings of the National Academy of Sciences of the United States of America | 1987 | 4,543 |
| 2 | Missing Pieces in the NF-κB Puzzle | Cell | 2002 | 3,354 |
| 3 | The GTPase superfamily: conserved structure and molecular mechanism | Nature | 1991 | 3,349 |
| 4 | Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin | Nature | 1997 | 3,053 |
| 5 | A central role for JNK in obesity and insulin resistance | Nature | 2002 | 2,874 |
| 6 | NF-κB at the crossroads of life and death | Nature Immunology | 2002 | 2,611 |
| 7 | The Fluorescent Toolbox for Assessing Protein Location and Function | Science | 2006 | 2,583 |
| 8 | AP-1 function and regulation | Current Opinion in Cell Biology | 1997 | 2,516 |
| 9 | AP-1 as a regulator of cell life and death | Nature Cell Biology | 2002 | 2,448 |
| 10 | The GTPase superfamily: a conserved switch for diverse cell functions | Nature | 1990 | 2,407 |
| 11 | NF-κB in cancer: from innocent bystander to major culprit | Nature Reviews Cancer | 2002 | 2,341 |
| 12 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer | Cell | 2004 | 2,277 |
| 13 | Immunosuppression by Glucocorticoids: Inhibition of NF-kappaB Activity Through Induction of IkappaB Sy nthesis | Science | 1995 | 2,261 |
| 14 | The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases | Journal of Biological Chemistry | 1995 | 2,223 |
| 15 | Crystal Structure of the Aequorea victoria Green Fluorescent Protein | Science | 1996 | 2,108 |
| 16 | Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells | Science | 2002 | 2,096 |
| 17 | Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death | Cell | 1996 | 1,911 |
| 18 | Creating new fluorescent probes for cell biology | Nature Reviews Molecular Cell Biology | 2002 | 1,874 |
| 19 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer | Cancer Cell | 2009 | 1,851 |
| 20 | Improved green fluorescence | Nature | 1995 | 1,749 |
| 21 | The molecular logic of endocannabinoid signalling | Nature Reviews Neuroscience | 2003 | 1,745 |
| 22 | Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkbeta | Science | 2001 | 1,742 |
| 23 | Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer | Cell | 2015 | 1,716 |
| 24 | Protein Tyrosine Phosphatases in the Human Genome | Cell | 2004 | 1,697 |
| 25 | GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours | Nature | 1989 | 1,680 |
| 26 | Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction | Cell | 1990 | 1,618 |
| 27 | IKK-β links inflammation to obesity-induced insulin resistance | Nature Medicine | 2005 | 1,591 |
| 28 | Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 1,554 |
| 29 | Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs | Cell | 1995 | 1,515 |
| 30 | Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression | Cell | 2010 | 1,490 |
| 31 | AP-1 in cell proliferation and survival | Oncogene | 2001 | 1,485 |
| 32 | MRI-PET Registration with Automated Algorithm | Journal of Computer Assisted Tomography | 1993 | 1,467 |
| 33 | Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP | Cell | 1987 | 1,456 |
| 34 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 35 | Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer | Current Biology | 1996 | 1,412 |
| 36 | The regulation of transcription by phosphorylation | Cell | 1992 | 1,402 |
| 37 | The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes | Cell | 1988 | 1,369 |
| 38 | Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors | Science | 2005 | 1,357 |
| 39 | Modulation of anxiety through blockade of anandamide hydrolysis | Nature Medicine | 2003 | 1,306 |
| 40 | Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase | Nature | 2000 | 1,283 |
| 41 | Activation by IKKalpha of a Second, Evolutionary Conserved, NF-kappa B Signaling Pathway | Science | 2001 | 1,278 |
| 42 | The IKK NF-κB system: a treasure trove for drug development | Nature Reviews Drug Discovery | 2004 | 1,263 |
| 43 | The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 | Cell | 1988 | 1,258 |
| 44 | Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide | Annual Review of Pharmacology and Toxicology | 1990 | 1,251 |
| 45 | The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control | Cell | 2008 | 1,243 |
| 46 | Brain monoglyceride lipase participating in endocannabinoid inactivation | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 1,206 |
| 47 | Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors | Nature | 1995 | 1,191 |
| 48 | Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity | Cell | 2008 | 1,188 |
| 49 | p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling | Cell | 2008 | 1,166 |
| 50 | Fitting curves to data using nonlinear regression: a practical and nonmathematical review | FASEB Journal | 1987 | 1,150 |
