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Top Articles

#TitleJournalYearCitations
1Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicansImmunity2010648
2Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicansNature Immunology2007561
3An integrated expression atlas of miRNAs and their promoters in human and mouseNature Biotechnology2017456
4Evidence that reactive oxygen species do not mediate NF- B activationEMBO Journal2003363
5Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2Journal of Experimental Medicine2003353
6A Biomimetic Mussel‐Inspired ε‐Poly‐l‐lysine Hydrogel with Robust Tissue‐Anchor and Anti‐Infection CapacityAdvanced Functional Materials2017342
7Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption*Endocrinology1998341
8The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptorsNature Immunology2007300
9The LPS receptor (CD14) links innate immunity with Alzheimer's diseaseFASEB Journal2004290
10Saccharomyces cerevisiae‐ and Candida albicans‐Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14‐ and Toll‐Like Receptor 4‐Dependent MannerMicrobiology and Immunology2002263
11Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophagesBiochemical Pharmacology2003259
12Gene delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasoundJournal of Controlled Release2007225
13Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1Infection and Immunity2004223
14A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster FormationJournal of Neuroscience2002218
15Natural products reveal cancer cell dependence on oxysterol-binding proteinsNature Chemical Biology2011215
16Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the IntestineCell Host and Microbe2015215
17Total Synthesis of Aryl C-Glycoside Natural Products: Strategies and TacticsChemical Reviews2018207
18DNA strand-breaking activity and mutagenicity of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), a Maillard reaction product of glucose and glycineMutation Research - Genetic Toxicology and Environmental Mutagenesis1997199
19FANTOM5 CAGE profiles of human and mouse samplesScientific Data2017195
20Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micellesBiomaterials2013194
21Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibersGlia2007189
22Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposureJournal of Controlled Release2010187
23Antitumor .BETA.-Glucan from the Cultured Fruit Body of Agaricus blazei.Biological and Pharmaceutical Bulletin2001183
24Hypoglycemic Effects of Turmeric (Curcuma longa L. Rhizomes) on Genetically Diabetic KK-Ay MiceBiological and Pharmaceutical Bulletin2005175
25Potent estrogen agonists based on carborane as a hydrophobic skeletal structureChemistry and Biology2001172
26Difference in Effective Dosage of Genistein on Bone and Uterus in Ovariectomized MiceBiochemical and Biophysical Research Communications2000164
27An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with InflammationJournal of Experimental Medicine2003164
28Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbsBioorganic and Medicinal Chemistry Letters1997158
29Synthetic Methods for Fluorinated OlefinsEuropean Journal of Organic Chemistry2011156
30One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosisJournal of Controlled Release2009154
31Fe3O4 nanoparticle-supported Cu(ii)-β-cyclodextrin complex as a magnetically recoverable and reusable catalyst for the synthesis of symmetrical biaryls and 1,2,3-triazoles from aryl boronic acidsGreen Chemistry2013151
32DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acidsJournal of Inorganic Biochemistry2002150
33Blood vessels of human islets of Langerhans are surrounded by a double basement membraneDiabetologia2008147
34Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopyInternational Journal of Pharmaceutics1996146
35Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypesAnnals of the Rheumatic Diseases2016144
36Catalytic Enantioselective Synthesis of Atropisomeric Indoles with an NC Chiral AxisChemistry - A European Journal2010143
37Structure-Activity Relationship of (1.RAR.3)-.BETA.-D-Glucans in the Induction of Cytokine Production from Macrophages, in Vitro.Biological and Pharmaceutical Bulletin1995142
38DNA Damage by FasicularinJournal of the American Chemical Society2005142
39Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubblesJournal of Controlled Release2008134
40Effective gene delivery with novel liposomal bubbles and ultrasonic destruction technologyInternational Journal of Pharmaceutics2008133
41Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model ratsNeuroscience Letters2006130
42Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal AdministrationPharmaceutical Research2011130
43Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell SurfaceJournal of Biological Chemistry1998127
44Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in MiceJournal of Pharmacological Sciences2007124
45Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasoundJournal of Controlled Release2008124
46Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cellsCancer Research2002124
47Solubilization of yeast cell-wall β-(1→3)-d-glucan by sodium hypochlorite oxidation and dimethyl sulfoxide extractionCarbohydrate Research1999123
48Total Synthesis of (−)-Incarvilline, (+)-Incarvine C, and (−)-IncarvillateineJournal of the American Chemical Society2004119
49Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins.Biological and Pharmaceutical Bulletin2001118
50Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated ComplicationsMolecules2011115