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Department of Medical Biochemistry and Biophysics
›
top-articles
Department of Medical Biochemistry and Biophysics
52
(top 2%)
papers
3.8K
(top 1%)
citations
30
(top 1%)
h
-index
52
(top 1%)
g
-index
52
all documents
4.0K
doc citations
934
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Toward a unified nomenclature for mammalian ADP-ribosyltransferases
Trends in Biochemical Sciences
2010
724
2
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nature Biotechnology
2012
410
3
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
Proceedings of the National Academy of Sciences of the United States of America
2012
178
4
Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S
Journal of Biological Chemistry
2009
166
5
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Nature Structural and Molecular Biology
2011
147
6
PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
Journal of Biological Chemistry
2010
135
7
The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism
Biochimica Et Biophysica Acta - Molecular Basis of Disease
2012
132
8
Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design
Journal of Molecular Biology
2008
125
9
The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch
Journal of Biological Chemistry
2009
119
10
Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP
Journal of Molecular Biology
2007
117
11
Comparative Structural Analysis of Lipid Binding START Domains
PLoS ONE
2011
117
12
Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor
Journal of Medicinal Chemistry
2010
110
13
High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C
Proceedings of the National Academy of Sciences of the United States of America
2012
108
14
Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains
Structure
2013
107
15
Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3
Journal of Medicinal Chemistry
2009
88
16
Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates
Nature Methods
2009
78
17
Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888
Biochemistry
2010
72
18
Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein
Journal of Biological Chemistry
2015
70
19
Completing the family portrait of the anti‐apoptotic Bcl‐2 proteins: Crystal structure of human Bfl‐1 in complex with Bim
FEBS Letters
2008
64
20
The structure of human collapsin response mediator protein 2, a regulator of axonal growth
Journal of Neurochemistry
2007
63
21
Zinc Binding Catalytic Domain of Human Tankyrase 1
Journal of Molecular Biology
2008
56
22
Towards proteome scale antibody selections using phage display
New Biotechnology
2010
53
23
A general, robust method for the quality control of intact proteins using LC–ESI-MS
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2007
52
24
Structural genomics—Impact on biomedicine and drug discovery
Experimental Cell Research
2010
52
25
Crystal Structure of Human Inosine Triphosphatase
Journal of Biological Chemistry
2007
48
26
A secretory system for bacterial production of high‐profile protein targets
Protein Science
2011
39
27
The case for open‐access chemical biology
EMBO Reports
2009
37
28
Structural and Biophysical Characterization of Human myo-Inositol Oxygenase
Journal of Biological Chemistry
2008
35
29
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes
Nature Chemical Biology
2011
35
30
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
Acta Crystallographica Section F: Structural Biology Communications
2006
33
31
An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries
Proteins: Structure, Function and Bioinformatics
2006
31
32
Substrate Specificity and Oligomerization of Human GMP Synthetase
Journal of Molecular Biology
2013
31
33
Crystal Structure of the ATPase Domain of the Human AAA+ Protein Paraplegin/SPG7
PLoS ONE
2009
30
34
Structural studies of tri-functional human GART
Nucleic Acids Research
2010
28
35
Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase
PLoS ONE
2012
28
36
Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif
Journal of Biological Chemistry
2010
26
37
Exploring the activity of tobacco etch virus protease in detergent solutions
Analytical Biochemistry
2008
25
38
Crystal structure of human diphosphoinositol phosphatase 1
Proteins: Structure, Function and Bioinformatics
2009
25
39
First Structure of a Eukaryotic Phosphohistidine Phosphatase
Journal of Biological Chemistry
2006
24
40
Structural Basis of Tumor Suppressor in Lung Cancer 1 (TSLC1) Binding to Differentially Expressed in Adenocarcinoma of the Lung (DAL-1/4.1B)
Journal of Biological Chemistry
2011
22
41
Structural Basis for Regulation of the Human Acetyl-CoA Thioesterase 12 and Interactions with the Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Domain
Journal of Biological Chemistry
2014
22
42
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
PLoS ONE
2015
22
43
The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle
Proteins: Structure, Function and Bioinformatics
2009
18
44
The Crystal Structure of a Human PP2A Phosphatase Activator Reveals a Novel Fold and Highly Conserved Cleft Implicated in Protein-Protein Interactions
Journal of Biological Chemistry
2006
17
45
Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism
PLoS ONE
2012
17
46
A software tool to accelerate design of protein constructs for recombinant expression
Protein Expression and Purification
2010
15
47
Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis
Structure
2016
14
48
Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue
Acta Crystallographica Section D: Biological Crystallography
2006
10
49
The crystal structure of human cleavage and polyadenylation specific factor‐5 reveals a dimeric Nudix protein with a conserved catalytic site
Proteins: Structure, Function and Bioinformatics
2008
10
50
Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase
PLoS ONE
2012
10
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