| # | Title | Journal | Year | Citations |
|---|
| 1 | Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults | Annals of Internal Medicine | 2015 | 2,001 |
| 2 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,536 |
| 3 | Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) | Critical Care Medicine | 2020 | 816 |
| 4 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 5 | Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients | Science Immunology | 2020 | 714 |
| 6 | A scoping review of rapid review methods | BMC Medicine | 2015 | 664 |
| 7 | Drug treatments for covid-19: living systematic review and network meta-analysis | BMJ, The | 2020 | 592 |
| 8 | Engaging patients to improve quality of care: a systematic review | Implementation Science | 2018 | 586 |
| 9 | Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries | Nature Medicine | 2021 | 529 |
| 10 | Patterns and Costs of Health Care Use of Children With Medical Complexity | Pediatrics | 2012 | 488 |
| 11 | 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis | Arthritis Care and Research | 2021 | 466 |
| 12 | Association Between Wait Time and 30-Day Mortality in Adults Undergoing Hip Fracture Surgery | JAMA - Journal of the American Medical Association | 2017 | 449 |
| 13 | Modern modelling techniques are data hungry: a simulation study for predicting dichotomous endpoints | BMC Medical Research Methodology | 2014 | 423 |
| 14 | The expanding role of primary care in cancer control | Lancet Oncology, The | 2015 | 399 |
| 15 | The increasing burden and complexity of multimorbidity | BMC Public Health | 2015 | 398 |
| 16 | Printed educational materials: effects on professional practice and healthcare outcomes | The Cochrane Library | 2012 | 389 |
| 17 | 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis | Arthritis and Rheumatology | 2021 | 339 |
| 18 | Obstructive Sleep Apnea and Risk of Cardiovascular Events and All-Cause Mortality: A Decade-Long Historical Cohort Study | PLoS Medicine | 2014 | 322 |
| 19 | Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032 | Osteoarthritis and Cartilage | 2014 | 322 |
| 20 | The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability | European Heart Journal | 2018 | 321 |
| 21 | Applications of artificial neural networks in health care organizational decision-making: A scoping review | PLoS ONE | 2019 | 313 |
| 22 | A game plan: Gamification design principles in mHealth applications for chronic disease management | Health Informatics Journal | 2016 | 298 |
| 23 | Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis | European Heart Journal | 2019 | 297 |
| 24 | Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update | Critical Care Medicine | 2021 | 289 |
| 25 | Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study | Critical Care | 2013 | 269 |
| 26 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 27 | Factors affecting return to work after injury or illness: best evidence synthesis of systematic reviews | Chiropractic & Manual Therapies | 2016 | 265 |
| 28 | Association of Neighborhood Walkability With Change in Overweight, Obesity, and Diabetes | JAMA - Journal of the American Medical Association | 2016 | 264 |
| 29 | Evaluation of the measurement properties of the Epworth sleepiness scale: A systematic review | Sleep Medicine Reviews | 2014 | 231 |
| 30 | Association Between Depression and Mortality in Patients Receiving Long-term Dialysis: A Systematic Review and Meta-analysis | American Journal of Kidney Diseases | 2014 | 225 |
| 31 | Serial Anti–Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes | JAMA Neurology | 2020 | 213 |
| 32 | Foundation models for generalist medical artificial intelligence | Nature | 2023 | 208 |
| 33 | Relation between surgeon volume and risk of complications after total hip arthroplasty: propensity score matched cohort study | BMJ, The | 2014 | 207 |
| 34 | Effectiveness of COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario | Nature Microbiology | 2022 | 194 |
| 35 | All-Cause Mortality and Serious Cardiovascular Events in People with Hip and Knee Osteoarthritis: A Population Based Cohort Study | PLoS ONE | 2014 | 193 |
| 36 | Untreated obstructive sleep apnea and the risk for serious long-term adverse outcomes: A systematic review | Sleep Medicine Reviews | 2014 | 182 |
| 37 | Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis | BMJ, The | 2016 | 180 |
| 38 | Management of neck pain and associated disorders: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration | European Spine Journal | 2016 | 173 |
| 39 | Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 | Clinical Infectious Diseases | 2021 | 171 |
| 40 | The role of surgeon volume on patient outcome in total knee arthroplasty: a systematic review of the literature | BMC Musculoskeletal Disorders | 2012 | 169 |
| 41 | Impact of community based, specialist palliative care teams on hospitalisations and emergency department visits late in life and hospital deaths: a pooled analysis | BMJ, The | 2014 | 169 |
| 42 | Human Germline Genome Editing | American Journal of Human Genetics | 2017 | 168 |
| 43 | Identifying diabetes cases from administrative data: a population-based validation study | BMC Health Services Research | 2018 | 166 |
| 44 | Factors influencing adherence to cancer treatment in older adults with cancer: a systematic review | Annals of Oncology | 2014 | 160 |
| 45 | COVID-19 Vaccine Hesitancy in Canada: Content Analysis of Tweets Using the Theoretical Domains Framework | Journal of Medical Internet Research | 2021 | 160 |
| 46 | Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations | Science of the Total Environment | 2021 | 159 |
| 47 | Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis | BMJ Open | 2017 | 154 |
| 48 | Beyond the Randomized Controlled Trial: A Review of Alternatives in mHealth Clinical Trial Methods | JMIR MHealth and UHealth | 2016 | 148 |
| 49 | Association of Surgeon-Patient Sex Concordance With Postoperative Outcomes | JAMA Surgery | 2022 | 148 |
| 50 | The Matthews Correlation Coefficient (MCC) is More Informative Than Cohen’s Kappa and Brier Score in Binary Classification Assessment | IEEE Access | 2021 | 147 |
