# | Title | Journal | Year | Citations |
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1 | Structural Simplification of Natural Products | Chemical Reviews | 2019 | 157 |
2 | Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents | Journal of Medicinal Chemistry | 2015 | 156 |
3 | New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations | Journal of Medicinal Chemistry | 2012 | 146 |
4 | New Lead Structures in Antifungal Drug Discovery | Current Medicinal Chemistry | 2011 | 141 |
5 | State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors | Chemical Society Reviews | 2015 | 132 |
6 | Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search | Journal of Medicinal Chemistry | 2014 | 127 |
7 | Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents | Journal of Medicinal Chemistry | 2010 | 122 |
8 | ADMET evaluation in drug discovery: 15. Accurate prediction of rat oral acute toxicity using relevance vector machine and consensus modeling | Journal of Cheminformatics | 2016 | 102 |
9 | Design, Synthesis, and Antihepatitis B Virus Activities of Novel 2-Pyridone Derivatives | Journal of Medicinal Chemistry | 2010 | 94 |
10 | Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors | Organic Letters | 2016 | 77 |
11 | Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures | European Journal of Organic Chemistry | 2015 | 67 |
12 | Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones | Chemical Communications | 2013 | 60 |
13 | Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents | Journal of Medicinal Chemistry | 2018 | 59 |
14 | Design and Synthesis of Cyclopropylamide Analogues of Combretastatin-A4 as Novel Microtubule-Stabilizing Agents | Journal of Medicinal Chemistry | 2013 | 58 |
15 | Effects of hydrogen-rich water on depressive-like behavior in mice | Scientific Reports | 2016 | 57 |
16 | Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update | Medicinal Research Reviews | 2013 | 56 |
17 | Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy | Journal of Medicinal Chemistry | 2016 | 53 |
18 | Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review | Current Medicinal Chemistry | 2014 | 53 |
19 | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14α-demethylase (CYP51) of fungi | Bioorganic and Medicinal Chemistry Letters | 2006 | 49 |
20 | Structural simplification: an efficient strategy in lead optimization | Acta Pharmaceutica Sinica B | 2019 | 49 |
21 | Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer | Journal of Medicinal Chemistry | 2020 | 47 |
22 | Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis | Journal of Medicinal Chemistry | 2020 | 45 |
23 | Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer | Journal of Medicinal Chemistry | 2020 | 43 |
24 | Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic | ACS Chemical Biology | 2013 | 42 |
25 | Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51) | European Journal of Medicinal Chemistry | 2007 | 41 |
26 | Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies | ACS Combinatorial Science | 2013 | 41 |
27 | New Strategies in the Discovery of Novel Non-Camptothecin Topoisomerase I Inhibitors | Current Medicinal Chemistry | 2011 | 40 |
28 | Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections | Journal of Medicinal Chemistry | 2016 | 40 |
29 | Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity | Acta Pharmaceutica Sinica B | 2020 | 38 |
30 | Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis | ACS Infectious Diseases | 2020 | 35 |
31 | Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis | Journal of Medicinal Chemistry | 2021 | 35 |
32 | Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis | Free Radical Biology and Medicine | 2018 | 32 |
33 | Novel conformationally restricted triazole derivatives with potent antifungal activity | European Journal of Medicinal Chemistry | 2010 | 30 |
34 | Chemical Composition and Antidiabetic Activity of Opuntia Milpa Alta Extracts | Chemistry and Biodiversity | 2010 | 29 |
35 | Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates | Bioorganic and Medicinal Chemistry Letters | 2011 | 29 |
36 | Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity | European Journal of Medicinal Chemistry | 2012 | 29 |
37 | Design and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents | European Journal of Medicinal Chemistry | 2013 | 27 |
38 | Strategies in the discovery of novel antifungal scaffolds | Future Medicinal Chemistry | 2016 | 27 |
39 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry | European Journal of Medicinal Chemistry | 2012 | 26 |
40 | Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael–aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity | Organic and Biomolecular Chemistry | 2018 | 25 |
41 | Facile Assembly of Chiral Tetrahydrothiopyrans Containing Four Consecutive Stereocenters via an Organocatalytic Enantioselective Michael–Michael Cascade | Organic Letters | 2014 | 24 |
42 | Organocatalytic Asymmetric Synthesis of Spiro‐Tetrahydrothiophene Oxindoles Bearing Four Contiguous Stereocenters by One‐Pot Michael–Henry‐Cascade–Rearrangement Reactions | Chemistry - A European Journal | 2018 | 24 |
43 | Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis | Journal of Medicinal Chemistry | 2019 | 24 |
44 | Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer | ACS Medicinal Chemistry Letters | 2020 | 24 |
45 | Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives | Bioorganic and Medicinal Chemistry Letters | 2010 | 23 |
46 | Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides | European Journal of Medicinal Chemistry | 2012 | 23 |
47 | Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method | Bioorganic and Medicinal Chemistry | 2007 | 22 |
48 | Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans | European Journal of Medicinal Chemistry | 2022 | 22 |
49 | Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers | Bioorganic and Medicinal Chemistry Letters | 2008 | 21 |
50 | Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA | ChemMedChem | 2018 | 20 |