| # | Title | Journal | Year | Citations |
|---|
| 1 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 2 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 3 | Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software | Nature Methods | 2017 | 635 |
| 4 | Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals | BMC Cancer | 2011 | 398 |
| 5 | An overview of the healthcare system in Taiwan | London Journal of Primary Care | 2010 | 373 |
| 6 | The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals | Nature Genetics | 2016 | 362 |
| 7 | The trans-ancestral genomic architecture of glycemic traits | Nature Genetics | 2021 | 341 |
| 8 | Sex Differences in High‐fat Diet‐induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice | Obesity | 2010 | 330 |
| 9 | Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin | Journal of Alzheimer's Disease | 2011 | 291 |
| 10 | Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia | Nature Genetics | 2012 | 286 |
| 11 | Long-Term Risk of Coronary Events after AKI | Journal of the American Society of Nephrology: JASN | 2014 | 262 |
| 12 | Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms | Nature Genetics | 2017 | 260 |
| 13 | Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium | BMJ, The | 2013 | 239 |
| 14 | Maintenance of duplicate genes and their functional redundancy by reduced expression | Trends in Genetics | 2010 | 235 |
| 15 | Genomic patterns of pleiotropy and the evolution of complexity | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 218 |
| 16 | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease | Nature Genetics | 2017 | 218 |
| 17 | Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes | Diabetes Care | 2013 | 213 |
| 18 | Accurate binning of metagenomic contigs via automated clustering sequences using information of genomic signatures and marker genes | Scientific Reports | 2016 | 212 |
| 19 | Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort | Parkinsonism and Related Disorders | 2012 | 200 |
| 20 | Systematic review and meta-analysis of epidemiology of internet addiction | Neuroscience and Biobehavioral Reviews | 2020 | 197 |
| 21 | CISA: Contig Integrator for Sequence Assembly of Bacterial Genomes | PLoS ONE | 2013 | 193 |
| 22 | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index | Human Molecular Genetics | 2014 | 192 |
| 23 | The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia | PLoS Genetics | 2010 | 168 |
| 24 | Renoprotective Effect of Renin-Angiotensin-Aldosterone System Blockade in Patients With Predialysis Advanced Chronic Kidney Disease, Hypertension, and Anemia | JAMA Internal Medicine | 2014 | 167 |
| 25 | Health literacy, health status, and healthcare utilization of Taiwanese adults: results from a national survey | BMC Public Health | 2010 | 166 |
| 26 | Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study | British Journal of Psychiatry | 2012 | 156 |
| 27 | Circulating interleukin‐6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy | International Journal of Cancer | 2013 | 155 |
| 28 | Perioperative/Postoperative Atrial Fibrillation and Risk of Subsequent Stroke and/or Mortality | Stroke | 2019 | 147 |
| 29 | Antipsychotic Drugs and the Risk of Ventricular Arrhythmia and/or Sudden Cardiac Death: A Nation‐wide Case‐Crossover Study | Journal of the American Heart Association | 2015 | 137 |
| 30 | Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels | Human Molecular Genetics | 2017 | 135 |
| 31 | An Experimentally Validated Genome-Scale Metabolic Reconstruction of Klebsiella pneumoniae MGH 78578, i YL1228 | Journal of Bacteriology | 2011 | 132 |
| 32 | The impact of universal National Health Insurance on population health: the experience of Taiwan | BMC Health Services Research | 2010 | 131 |
| 33 | Poverty Increases Type 2 Diabetes Incidence and Inequality of Care Despite Universal Health Coverage | Diabetes Care | 2012 | 130 |
| 34 | A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer | Annals of Oncology | 2015 | 130 |
| 35 | A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2 | BMC Systems Biology | 2011 | 128 |
| 36 | Standing genetic variation as the predominant source for adaptation of a songbird | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 128 |
| 37 | Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study | Lancet Diabetes and Endocrinology,the | 2015 | 122 |
| 38 | The Impact of Acute Kidney Injury on the Long‐term Risk of Stroke | Journal of the American Heart Association | 2014 | 118 |
| 39 | Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: a matched cohort study | British Journal of Nutrition | 2015 | 114 |
| 40 | A pilot randomized controlled trial to improve geriatric frailty | BMC Geriatrics | 2012 | 112 |
| 41 | Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained | PLoS Genetics | 2013 | 112 |
| 42 | Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries | International Journal of Cancer | 2015 | 112 |
| 43 | Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice | Gut | 2019 | 108 |
| 44 | Long term outcome of Aldosteronism after target treatments | Scientific Reports | 2016 | 106 |
| 45 | Final results of a randomized phase III trial of induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in patients with stage IVA and IVB nasopharyngeal carcinoma-Taiwan Cooperative Oncology Group (TCOG) 1303 Study | Annals of Oncology | 2018 | 103 |
| 46 | Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking | Cancer Causes and Control | 2010 | 102 |
| 47 | Epidemiology of sarcopenia among community‐dwelling older adults in Taiwan: A pooled analysis for a broader adoption of sarcopenia assessments | Geriatrics and Gerontology International | 2014 | 101 |
| 48 | Characterization of Large Structural Genetic Mosaicism in Human Autosomes | American Journal of Human Genetics | 2015 | 101 |
| 49 | Morbid obesity in Taiwan: Prevalence, trends, associated social demographics, and lifestyle factors | PLoS ONE | 2017 | 100 |
| 50 | Burden of Total and Cause-Specific Mortality Related to Tobacco Smoking among Adults Aged ≥45 Years in Asia: A Pooled Analysis of 21 Cohorts | PLoS Medicine | 2014 | 98 |
