| # | Title | Journal | Year | Citations |
|---|
| 1 | MolProbity: all-atom structure validation for macromolecular crystallography | Acta Crystallographica Section D: Biological Crystallography | 2010 | 12,318 |
| 2 | Structure validation by Cα geometry: ϕ,ψ and Cβ deviation | Proteins: Structure, Function and Bioinformatics | 2003 | 4,134 |
| 3 | Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix | Acta Crystallographica Section D: Structural Biology | 2019 | 4,060 |
| 4 | MolProbity: all-atom contacts and structure validation for proteins and nucleic acids | Nucleic Acids Research | 2007 | 3,443 |
| 5 | MolProbity: More and better reference data for improved all‐atom structure validation | Protein Science | 2018 | 2,776 |
| 6 | Amino acid preferences for specific locations at the ends of alpha helices | Science | 1988 | 1,458 |
| 7 | MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes | Nucleic Acids Research | 2004 | 938 |
| 8 | Natural -sheet proteins use negative design to avoid edge-to-edge aggregation | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 744 |
| 9 | How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase | Science | 1994 | 626 |
| 10 | Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses | Science | 1987 | 595 |
| 11 | Crystal Structure of DMSO Reductase: Redox-Linked Changes in Molybdopterin Coordination | Science | 1996 | 498 |
| 12 | Conformational selection or induced fit: A flux description of reaction mechanism | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 492 |
| 13 | Requirement for Superoxide in Excitotoxic Cell Death | Neuron | 1996 | 426 |
| 14 | De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence | Science | 1990 | 419 |
| 15 | Molecularly inherent voltage-controlled conductance switching | Nature Materials | 2005 | 352 |
| 16 | Alternate States of Proteins Revealed by Detailed Energy Landscape Mapping | Journal of Molecular Biology | 2011 | 324 |
| 17 | Emergent bistability by a growth-modulating positive feedback circuit | Nature Chemical Biology | 2009 | 306 |
| 18 | Manganic Porphyrins Possess Catalase Activity and Protect Endothelial Cells against Hydrogen Peroxide-Mediated Injury | Archives of Biochemistry and Biophysics | 1997 | 285 |
| 19 | A Mouse Macrophage Lipidome | Journal of Biological Chemistry | 2010 | 260 |
| 20 | The ANK repeat: a ubiquitous motif involved in macromolecular recognition | Trends in Cell Biology | 1992 | 252 |
| 21 | The Backrub Motion: How Protein Backbone Shrugs When a Sidechain Dances | Structure | 2006 | 237 |
| 22 | Flexibility, Diversity, and Cooperativity: Pillars of Enzyme Catalysis | Biochemistry | 2011 | 235 |
| 23 | The Molecular Organization of Lipids in the Membrane of Escherichia coli: Phase Transitions | Proceedings of the National Academy of Sciences of the United States of America | 1971 | 208 |
| 24 | The kinemage: A tool for scientific communication | Protein Science | 1992 | 208 |
| 25 | Developmental mechanism of the periodic membrane skeleton in axons | ELife | 2014 | 199 |
| 26 | RNA backbone is rotameric | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 184 |
| 27 | Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies | Journal of Experimental Medicine | 2013 | 171 |
| 28 | LPS remodeling is an evolved survival strategy for bacteria | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 167 |
| 29 | Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit | Journal of Molecular Biology | 1976 | 160 |
| 30 | From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields | Chemical Reviews | 2016 | 155 |
| 31 | Metalloporphyrins are potent inhibitors of lipid peroxidation | Free Radical Biology and Medicine | 1999 | 149 |
| 32 | A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing | Journal of Extracellular Vesicles | 2016 | 142 |
| 33 | Physical constraints on charge transport through bacterial nanowires | Faraday Discussions | 2012 | 139 |
| 34 | Injectable tissue integrating networks from recombinant polypeptides with tunable order | Nature Materials | 2018 | 132 |
| 35 | Structural analysis, identification, and design of calcium-binding sites in proteins | Proteins: Structure, Function and Bioinformatics | 2002 | 125 |
| 36 | Lysosomal Hyaluronidase from Rat Liver | Journal of Biological Chemistry | 1967 | 120 |
| 37 | The tyrosine corner: A feature of most greek key β‐barrel proteins | Protein Science | 1994 | 116 |
| 38 | The Alacoil: A very tight, antiparallel coiled‐coil of helices | Protein Science | 1995 | 114 |
| 39 | Predicting resistance mutations using protein design algorithms | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 113 |
| 40 | DNase-resistant transfer of chromosomal cat and tet insertions by filter mating in pneumococcus | Plasmid | 1980 | 109 |
| 41 | Idealized atomic coordinates of yeast phenylalanine transfer RNA | Biochemical and Biophysical Research Communications | 1976 | 103 |
| 42 | Spectroscopic and Dynamic Studies of the Epidermal Chromophores trans-Urocanic Acid and Eumelanin | Accounts of Chemical Research | 2000 | 102 |
| 43 | Breakage prior to entry of donor DNA in Pneumococcus transformation | Nucleic Acids and Protein Synthesis | 1973 | 99 |
| 44 | Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ | Journal of Biological Chemistry | 2012 | 98 |
| 45 | Development of Recombinant Hemoglobin-Based Oxygen Carriers | Antioxidants and Redox Signaling | 2013 | 96 |
| 46 | De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy | Nature Chemistry | 2017 | 93 |
| 47 | 5-Azacytidine–Induced Methyltransferase-DNA Adducts Block DNA Replication In vivo | Cancer Research | 2007 | 91 |
| 48 | Sex steroid receptor analysis in human melanoma | Cancer | 1980 | 90 |
| 49 | Molprobity's ultimate rotamer-library distributions for model validation | Proteins: Structure, Function and Bioinformatics | 2016 | 90 |
| 50 | Visualization of the same PtK2 cytoskeletons by both immunofluorescence and low power electron microscopy | Experimental Cell Research | 1978 | 89 |
