| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Drug repurposing: progress, challenges and recommendations | Nature Reviews Drug Discovery | 2019 | 2,956 |
| 2 | antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters | Nucleic Acids Research | 2015 | 1,797 |
| 3 | antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification | Nucleic Acids Research | 2017 | 1,217 |
| 4 | A community-driven global reconstruction of human metabolism | Nature Biotechnology | 2013 | 936 |
| 5 | The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics | Nature Chemistry | 2014 | 772 |
| 6 | Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015 | 743 |
| 7 | Water Determines the Structure and Dynamics of Proteins | Chemical Reviews | 2016 | 697 |
| 8 | The role of glutathione reductase and related enzymes on cellular redox homoeostasis network | Free Radical Biology and Medicine | 2016 | 667 |
| 9 | A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding | Analytica Chimica Acta | 2015 | 659 |
| 10 | Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering | Communications Biology | 2019 | 620 |
| 11 | Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies | Metabolomics | 2018 | 561 |
| 12 | Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies | Chemical Reviews | 2015 | 543 |
| 13 | Towards the sustainable discovery and development of new antibiotics | Nature Reviews Chemistry | 2021 | 541 |
| 14 | On Splitting Training and Validation Set: A Comparative Study of Cross-Validation, Bootstrap and Systematic Sampling for Estimating the Generalization Performance of Supervised Learning | Journal of Analysis and Testing | 2018 | 496 |
| 15 | Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells | Metallomics | 2014 | 475 |
| 16 | Protein–Sol: a web tool for predicting protein solubility from sequence | Bioinformatics | 2017 | 467 |
| 17 | Microbes and Alzheimer’s Disease | Journal of Alzheimer's Disease | 2016 | 445 |
| 18 | Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing | Journal of Dermatological Science | 2013 | 398 |
| 19 | Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast | Molecular Biology and Evolution | 2013 | 384 |
| 20 | Using text mining for study identification in systematic reviews: a systematic review of current approaches | Systematic Reviews | 2015 | 378 |
| 21 | Fingerprinting food: current technologies for the detection of food adulteration and contamination | Chemical Society Reviews | 2012 | 373 |
| 22 | Protons and Hydroxide Ions in Aqueous Systems | Chemical Reviews | 2016 | 373 |
| 23 | The dormant blood microbiome in chronic, inflammatory diseases | FEMS Microbiology Reviews | 2015 | 370 |
| 24 | S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications | ChemBioChem | 2012 | 359 |
| 25 | Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort | Allergy: European Journal of Allergy and Clinical Immunology | 2015 | 358 |
| 26 | Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines | Topics in Catalysis | 2014 | 349 |
| 27 | Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways | ACS Catalysis | 2017 | 341 |
| 28 | Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 331 |
| 29 | Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently | Chemical Society Reviews | 2015 | 323 |
| 30 | Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes | Nature Chemistry | 2013 | 322 |
| 31 | Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products | Journal of the American Chemical Society | 2013 | 320 |
| 32 | Biocatalytic retrosynthesis | Nature Chemical Biology | 2013 | 308 |
| 33 | Extending the application of biocatalysis to meet the challenges of drug development | Nature Reviews Chemistry | 2018 | 308 |
| 34 | A reductive aminase from Aspergillus oryzae | Nature Chemistry | 2017 | 306 |
| 35 | Unusual Cytochrome P450 Enzymes and Reactions | Journal of Biological Chemistry | 2013 | 283 |
| 36 | Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts | ACS Catalysis | 2017 | 273 |
| 37 | Inhibition of protein aggregation and amyloid formation by small molecules | Current Opinion in Structural Biology | 2015 | 269 |
| 38 | Growing a circular economy with fungal biotechnology: a white paper | Fungal Biology and Biotechnology | 2020 | 261 |
| 39 | The need for transparency and good practices in the qPCR literature | Nature Methods | 2013 | 257 |
| 40 | Recon 2.2: from reconstruction to model of human metabolism | Metabolomics | 2016 | 250 |
| 41 | Developing and understanding biofluid vibrational spectroscopy: a critical review | Chemical Society Reviews | 2016 | 250 |
| 42 | Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering | Materials | 2016 | 249 |
| 43 | Development of Halogenase Enzymes for Use in Synthesis | Chemical Reviews | 2018 | 249 |
| 44 | Enantioselective Chemo‐ and Biocatalysis: Partners in Retrosynthesis | Angewandte Chemie - International Edition | 2017 | 248 |
| 45 | The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device | ACS Central Science | 2020 | 246 |
| 46 | Recent advances in engineering nonribosomal peptide assembly lines | Natural Product Reports | 2016 | 227 |
| 47 | Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology | Current Opinion in Chemical Biology | 2016 | 224 |
| 48 | Three geographically separate domestications of Asian rice | Nature Plants | 2015 | 212 |
| 49 | Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals | Organic Process Research and Development | 2019 | 212 |
| 50 | Imine reductases (IREDs) | Current Opinion in Chemical Biology | 2017 | 211 |
