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Top Articles

#TitleJournalYearCitations
1Chlorogenic acid (CGA): A pharmacological review and call for further researchBiomedicine and Pharmacotherapy2018899
2The role of JAK/STAT signaling pathway and its inhibitors in diseasesInternational Immunopharmacology2020424
3Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategyNature Communications2019377
4Chitosan oligosaccharide (COS): An overviewInternational Journal of Biological Macromolecules2019313
5Biodegradation of polyethylene microplastic particles by the fungus Aspergillus flavus from the guts of wax moth Galleria mellonellaScience of the Total Environment2020257
6In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal–Organic Frameworks NanomaterialsACS Nano2017235
7Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriersDrug Discovery Today2013212
8Carbon dots: Applications in bioimaging and theranosticsInternational Journal of Pharmaceutics2019199
9Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer CellsACS Nano2018188
10Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s diseaseProceedings of the National Academy of Sciences of the United States of America2015187
11Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinomaActa Pharmaceutica Sinica B2022181
12Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful toolAdvanced Drug Delivery Reviews2019178
13Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailabilityInternational Journal of Pharmaceutics2010170
14Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with AntiinflammatoryAntioxidants and Redox Signaling2010170
15Microglia: Housekeeper of the Central Nervous SystemCellular and Molecular Neurobiology2018170
16The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative stateChemico-Biological Interactions2016168
17Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-κB pathwayInternational Immunopharmacology2015167
18Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administrationEuropean Journal of Pharmaceutical Sciences2012161
19Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug deliveryJournal of Controlled Release2009160
20NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in CancerJournal of Medicinal Chemistry2018149
21Biopharmaceutics classification and intestinal absorption study of apigeninInternational Journal of Pharmaceutics2012147
22The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in miceInternational Immunopharmacology2015143
23Potential biomedical applications of marine algaeBioresource Technology2017142
24Organocatalyzed Asymmetric 1,6-Conjugate Addition of para-Quinone Methides with DicyanoolefinsOrganic Letters2016135
25Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailabilityActa Pharmacologica Sinica2010131
26Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseasesBiomedicine and Pharmacotherapy2018130
27Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s diseaseBehavioural Brain Research2015127
28Protic ionic liquids for the selective absorption of H2S from CO2: Thermodynamic analysisAICHE Journal2014123
29Advances in coamorphous drug delivery systemsActa Pharmaceutica Sinica B2019123
30Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targetingBiomaterials Science2019122
31Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitroInternational Immunopharmacology2015121
32Aqueous Solubility and Degradation Kinetics of the Phytochemical Anticancer Thymoquinone; Probing the Effects of Solvents, pH and LightMolecules2014119
33Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosanBiomaterials2014118
34CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary AminesOrganic Letters2012113
35Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applicationsActa Pharmaceutica Sinica B2021111
36Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo resultsInternational Journal of Pharmaceutics2009109
37Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methidesChemical Communications2015108
38Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatinEuropean Journal of Medicinal Chemistry2014106
39Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndromeActa Pharmaceutica Sinica B2022106
40Controllable Rh(III)-Catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and BenzofuransOrganic Letters2016105
41Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho SignalingInflammation2016105
42Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancementEuropean Journal of Pharmaceutical Sciences2013104
43Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distributionInternational Journal of Pharmaceutics2010103
44Coamorphous repaglinide–saccharin with enhanced dissolutionInternational Journal of Pharmaceutics2013103
45Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s diseaseProceedings of the National Academy of Sciences of the United States of America2017102
46Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein KnockdownJournal of Medicinal Chemistry2020102
47Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapyBiomaterials2012100
48Nanocarrier‐Mediated Cytosolic Delivery of BiopharmaceuticalsAdvanced Functional Materials202099
49Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activityBioorganic Chemistry201898
50Drug nanocrystals: Fabrication methods and promising therapeutic applicationsInternational Journal of Pharmaceutics201997