| # | Title | Journal | Year | Citations |
|---|
| 1 | Health Care Costs and Mortality Associated with Nosocomial Diarrhea Due to Clostridium difficile | Clinical Infectious Diseases | 2002 | 694 |
| 2 | Frailty in Older Adults Undergoing Aortic Valve Replacement | Journal of the American College of Cardiology | 2017 | 561 |
| 3 | Measuring Frailty in Medicare Data: Development and Validation of a Claims-Based Frailty Index | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2018 | 303 |
| 4 | Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus | Nature | 2014 | 285 |
| 5 | The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects | Regulatory Peptides | 1994 | 281 |
| 6 | Hypertension, Orthostatic Hypotension, and the Risk of Falls in a Community-Dwelling Elderly Population: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study | Journal of the American Geriatrics Society | 2011 | 254 |
| 7 | Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy | American Journal of Medicine | 1991 | 247 |
| 8 | Conceptual and Measurement Challenges in Research on Cognitive Reserve | Journal of the International Neuropsychological Society | 2011 | 237 |
| 9 | Physiological complexity and system adaptability: evidence from postural control dynamics of older adults | Journal of Applied Physiology | 2010 | 235 |
| 10 | Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer | Nature Medicine | 2015 | 220 |
| 11 | The Nonlinear Relationship Between Gait Speed and Falls: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study | Journal of the American Geriatrics Society | 2011 | 218 |
| 12 | The microvascular frontal-subcortical syndrome of aging | Neurobiology of Aging | 2002 | 217 |
| 13 | Global and Regional Effects of Type 2 Diabetes on Brain Tissue Volumes and Cerebral Vasoreactivity | Diabetes Care | 2007 | 211 |
| 14 | Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery | JAMA - Journal of the American Medical Association | 2019 | 199 |
| 15 | Interpretability of Cancer Clinical Trial Results Using Restricted Mean Survival Time as an Alternative to the Hazard Ratio | JAMA Oncology | 2017 | 179 |
| 16 | Foot pressure distribution during walking in young and old adults | BMC Geriatrics | 2005 | 175 |
| 17 | Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2008 | 172 |
| 18 | Hypertension, White Matter Hyperintensities, and Concurrent Impairments in Mobility, Cognition, and Mood | Circulation | 2011 | 166 |
| 19 | Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy | International Journal of Molecular Sciences | 2015 | 165 |
| 20 | DJ-1 Transcriptionally Up-regulates the Human Tyrosine Hydroxylase by Inhibiting the Sumoylation of Pyrimidine Tract-binding Protein-associated Splicing Factor | Journal of Biological Chemistry | 2006 | 162 |
| 21 | Frequent Hypoglycemia Among Elderly Patients With Poor Glycemic Control | Archives of Internal Medicine | 2011 | 158 |
| 22 | Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR-pQCT Study | Journal of Bone and Mineral Research | 2018 | 148 |
| 23 | Cerebral Blood Flow Velocity and Periventricular White Matter Hyperintensities in Type 2 Diabetes | Diabetes Care | 2006 | 144 |
| 24 | Survival and Comfort After Treatment of Pneumonia in Advanced Dementia | Archives of Internal Medicine | 2010 | 144 |
| 25 | Delirium is associated with early postoperative cognitive dysfunction | Anaesthesia | 2008 | 141 |
| 26 | Restricted Mean Survival Time as a Measure to Interpret Clinical Trial Results | JAMA Cardiology | 2017 | 139 |
| 27 | Physiologic complexity and aging: Implications for physical function and rehabilitation | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2013 | 131 |
| 28 | Validation of a Claims-Based Frailty Index Against Physical Performance and Adverse Health Outcomes in the Health and Retirement Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2019 | 130 |
| 29 | Adiponectin Levels and the Risk of Hypertension | Hypertension | 2013 | 126 |
| 30 | Measuring frailty using claims data for pharmacoepidemiologic studies of mortality in older adults: evidence and recommendations | Pharmacoepidemiology and Drug Safety | 2014 | 114 |
| 31 | Delirium in the Elderly | Psychiatric Clinics of North America | 2018 | 109 |
| 32 | Dementia Medications and Risk of Falls, Syncope, and Related Adverse Events: Meta-Analysis of Randomized Controlled Trials | Journal of the American Geriatrics Society | 2011 | 108 |
| 33 | Residential Proximity to Nearest Major Roadway and Cognitive Function in Community‐Dwelling Seniors: Results from the MOBILIZE Boston Study | Journal of the American Geriatrics Society | 2012 | 106 |
| 34 | A Novel Aging Phenotype of Slow Gait, Impaired Executive Function, and Depressive Symptoms: Relationship to Blood Pressure and Other Cardiovascular Risks | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2009 | 105 |
| 35 | The Burden of Frailty Among U.S. Veterans and Its Association With Mortality, 2002–2012 | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2019 | 105 |
| 36 | Healthcare Proxies of Nursing Home Residents with Advanced Dementia: Decisions They Confront and Their Satisfaction with Decision‐Making | Journal of the American Geriatrics Society | 2009 | 101 |
| 37 | Prevalence of Frailty and Aging-Related Health Conditions in Older Koreans in Rural Communities: a Cross-Sectional Analysis of the Aging Study of Pyeongchang Rural Area | Journal of Korean Medical Science | 2016 | 101 |
| 38 | ASH Position Paper: Evaluation and Treatment of Orthostatic Hypotension | Journal of Clinical Hypertension | 2013 | 96 |
| 39 | Bisphosphonates and Risk of Cardiovascular Events: A Meta-Analysis | PLoS ONE | 2015 | 94 |
| 40 | Model-Based Noninvasive Estimation of Intracranial Pressure from Cerebral Blood Flow Velocity and Arterial Pressure | Science Translational Medicine | 2012 | 92 |
| 41 | Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer’s disease | Acta Neuropathologica | 2011 | 90 |
| 42 | Differentiating between orchiectomized rats and controls using measurements of trabecular bone density: A comparison among DXA, Histomorphometry, and peripheral quantitative computerized tomography | Calcified Tissue International | 1995 | 88 |
| 43 | Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension | BioMedical Engineering OnLine | 2004 | 88 |
| 44 | Altered cerebral vasoregulation in hypertension and stroke | Neurology | 2003 | 82 |
| 45 | Utility of Biochemical Markers of Bone Turnover in the Follow-up of Patients Treated with Bisphosphonates | Calcified Tissue International | 1998 | 79 |
| 46 | Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function | Cell Death and Disease | 2014 | 79 |
| 47 | The effects of body mass index on cerebral blood flow velocity | Clinical Autonomic Research | 2008 | 78 |
| 48 | Evaluation of algorithms to identify delirium in administrative claims and drug utilization database | Pharmacoepidemiology and Drug Safety | 2017 | 78 |
| 49 | The National Task Group on Intellectual Disabilities and Dementia Practices Consensus Recommendations for the Evaluation and Management of Dementia in Adults With Intellectual Disabilities | Mayo Clinic Proceedings | 2013 | 77 |
| 50 | Effect of Antihypertensive Therapy on Cognitive Function in Early Executive Cognitive Impairment: A Double-blind Randomized Clinical Trial | Archives of Internal Medicine | 2012 | 76 |
