# | Title | Journal | Year | Citations |
---|
1 | Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology | Journal of Medicinal Chemistry | 2013 | 1,002 |
2 | In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer | Nature Medicine | 2014 | 242 |
3 | Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53 | Journal of the American Chemical Society | 2012 | 202 |
4 | Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets | Journal of Chemical Information and Modeling | 2013 | 134 |
5 | Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood | Inflammation | 2015 | 92 |
6 | Inhibitors of c-Jun N-Terminal Kinases: An Update | Journal of Medicinal Chemistry | 2015 | 81 |
7 | Inhibition of GSK3 differentially modulates NF-κB, CREB, AP-1 and β-catenin signaling in hepatocytes, but fails to promote TNF-α-induced apoptosis | Experimental Cell Research | 2008 | 69 |
8 | DEKOIS: Demanding Evaluation Kits for Objective in Silico Screening — A Versatile Tool for Benchmarking Docking Programs and Scoring Functions | Journal of Chemical Information and Modeling | 2011 | 68 |
9 | Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action | Phytochemistry | 2012 | 60 |
10 | Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases | Journal of Medicinal Chemistry | 2015 | 43 |
11 | Design, Synthesis, and Biological Evaluation of Phenylamino-Substituted 6,11-Dihydro-dibenzo[b,e]oxepin-11-ones and Dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP Kinase Inhibitors | Journal of Medicinal Chemistry | 2006 | 40 |
12 | Are MAP Kinases Drug Targets? Yes, but Difficult Ones | ChemMedChem | 2007 | 40 |
13 | Optimization of a nonradioactive immunosorbent assay for p38α mitogen-activated protein kinase activity | Analytical Biochemistry | 2010 | 37 |
14 | Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors | Bioorganic and Medicinal Chemistry Letters | 2010 | 36 |
15 | Biological Evaluation and Structural Determinants of p38α Mitogen‐Activated‐Protein Kinase and c‐Jun‐N‐Terminal Kinase 3 Inhibition by Flavonoids | ChemBioChem | 2010 | 34 |
16 | Isoxazolone Based Inhibitors of p38 MAP Kinases | Journal of Medicinal Chemistry | 2008 | 32 |
17 | Substituted Isoxazoles as Potent Inhibitors of p38 MAP Kinase | ChemMedChem | 2006 | 31 |
18 | Novel Hinge‐Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure–Activity Relationship Study on Tofacitinib Bioisosteres | ChemMedChem | 2014 | 28 |
19 | Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors | European Journal of Medicinal Chemistry | 2019 | 26 |
20 | Aza-Analogue Dibenzepinone Scaffolds as p38 Mitogen-Activated Protein Kinase Inhibitors: Design, Synthesis, and Biological Data of Inhibitors with Improved Physicochemical Properties | Journal of Medicinal Chemistry | 2009 | 25 |
21 | Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents | Journal of Ethnopharmacology | 2014 | 24 |
22 | Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species | Cellular Physiology and Biochemistry | 2015 | 24 |
23 | Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine | Journal of Medicinal Chemistry | 2017 | 24 |
24 | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3 | ACS Omega | 2018 | 24 |
25 | Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere | ACS Chemical Biology | 2015 | 23 |
26 | Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1 | Clinical Pharmacology and Therapeutics | 2020 | 23 |
27 | A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells | International Journal of Molecular Sciences | 2021 | 22 |
28 | A direct ELISA assay for quantitative determination of the inhibitory potency of small molecules inhibitors for JNK3 | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 21 |
29 | Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production | PLoS ONE | 2012 | 21 |
30 | Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis | European Journal of Pharmacology | 2012 | 21 |
31 | pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening | Journal of Chemical Information and Modeling | 2015 | 20 |
32 | Antimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extract | Journal of Toxicology and Environmental Health - Part A: Current Issues | 2020 | 20 |
33 | SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol | BMJ Open | 2016 | 17 |
34 | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions | Scientific Reports | 2021 | 17 |
35 | Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors | Nature Communications | 2022 | 17 |
36 | Synthesis and Biological Testing of N‐Aminoimidazole‐Based p38α MAP Kinase Inhibitors | ChemMedChem | 2010 | 16 |
37 | Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions | Theranostics | 2019 | 16 |
38 | Neuroprotective Effect of Luteolin-7-O-Glucoside against 6-OHDA-Induced Damage in Undifferentiated and RA-Differentiated SH-SY5Y Cells | International Journal of Molecular Sciences | 2022 | 16 |
39 | Unexpected Reaction of 2-Alkylsulfanylimidazoles to Imidazol-2-ones: Pyridinylimidazol-2-ones as Novel Potent p38α Mitogen-Activated Protein Kinase Inhibitors | Journal of Medicinal Chemistry | 2010 | 15 |
40 | A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors | Analytical Methods | 2014 | 15 |
41 | Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and π⋯π interactions using N-methylacetamide | MedChemComm | 2016 | 14 |
42 | Myricetin inhibits panel of kinases implicated in tumorigenesis | Basic and Clinical Pharmacology and Toxicology | 2019 | 14 |
43 | ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury | Nature Communications | 2022 | 13 |
44 | Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells | Biomedicine and Pharmacotherapy | 2016 | 12 |
45 | Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks | ACS Medicinal Chemistry Letters | 2019 | 12 |
46 | Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448) | ACS Medicinal Chemistry Letters | 2022 | 11 |
47 | From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors | Molecules | 2017 | 10 |
48 | Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis | Inflammopharmacology | 2019 | 10 |
49 | A Special View of What Was Almost Forgotten: p38δ MAPK | Cancers | 2021 | 10 |
50 | Current jakinibs for the treatment of rheumatoid arthritis: a systematic review | Inflammopharmacology | 2021 | 10 |