| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial | Lancet Oncology, The | 2011 | 1,452 |
| 2 | Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells | Nature | 2005 | 1,398 |
| 3 | The evolutionary history of lethal metastatic prostate cancer | Nature | 2015 | 1,223 |
| 4 | Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA | Science Translational Medicine | 2012 | 1,113 |
| 5 | Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 1,062 |
| 6 | Multiple newly identified loci associated with prostate cancer susceptibility | Nature Genetics | 2008 | 798 |
| 7 | Breast-Cancer Risk in Families with Mutations in PALB2 | New England Journal of Medicine | 2014 | 763 |
| 8 | CD133, a novel marker for human prostatic epithelial stem cells | Journal of Cell Science | 2004 | 717 |
| 9 | Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data | Lancet Oncology, The | 2014 | 717 |
| 10 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 706 |
| 11 | Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review | Annals of Oncology | 2017 | 679 |
| 12 | Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype | Nature Reviews Cancer | 2009 | 618 |
| 13 | Phase III Study of R-CVP Compared With Cyclophosphamide, Vincristine, and Prednisone Alone in Patients With Previously Untreated Advanced Follicular Lymphoma | Journal of Clinical Oncology | 2008 | 559 |
| 14 | Eomesodermin is required for mouse trophoblast development and mesoderm formation | Nature | 2000 | 555 |
| 15 | IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas | Neuro-Oncology | 2009 | 512 |
| 16 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array | Nature Genetics | 2013 | 495 |
| 17 | Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer | Prostate | 2004 | 479 |
| 18 | The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies | Clinical and Translational Radiation Oncology | 2018 | 428 |
| 19 | Cancer therapy shapes the fitness landscape of clonal hematopoiesis | Nature Genetics | 2020 | 428 |
| 20 | A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer | Nature Genetics | 2014 | 411 |
| 21 | Spatial genomic heterogeneity within localized, multifocal prostate cancer | Nature Genetics | 2015 | 407 |
| 22 | Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Prospective Investigation into Cancer and Nutrition (EPIC) | Journal of the National Cancer Institute | 2005 | 396 |
| 23 | Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue | Nature Genetics | 2015 | 392 |
| 24 | Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer | Nature Genetics | 2014 | 379 |
| 25 | Tamoxifen-Induced Reduction in Mammographic Density and Breast Cancer Risk Reduction: A Nested Case-Control Study | Journal of the National Cancer Institute | 2011 | 366 |
| 26 | Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling | Science Translational Medicine | 2012 | 365 |
| 27 | Psychological consequences of predictive genetic testing: a systematic review | European Journal of Human Genetics | 2000 | 339 |
| 28 | Susceptibility of Human Metabolic Phenotypes to Dietary Modulation | Journal of Proteome Research | 2006 | 339 |
| 29 | MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study | Lancet Oncology, The | 2021 | 324 |
| 30 | Years of life lost (YLL) from cancer is an important measure of population burden — and should be considered when allocating research funds | British Journal of Cancer | 2005 | 319 |
| 31 | Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality | JAMA - Journal of the American Medical Association | 2018 | 318 |
| 32 | Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin | Gastroenterology | 2004 | 311 |
| 33 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial | Lancet Oncology, The | 2013 | 305 |
| 34 | Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study | Lancet Oncology, The | 2014 | 301 |
| 35 | SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease | Neuro-Oncology | 2013 | 289 |
| 36 | Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity | Cell Metabolism | 2016 | 282 |
| 37 | Multiple loci on 8q24 associated with prostate cancer susceptibility | Nature Genetics | 2009 | 274 |
| 38 | Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism | Journal of Clinical Endocrinology and Metabolism | 2005 | 269 |
| 39 | Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study | Nature Genetics | 2011 | 266 |
| 40 | Genotype‐phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium | Journal of Internal Medicine | 1995 | 265 |
| 41 | Transcriptional diversity during lineage commitment of human blood progenitors | Science | 2014 | 259 |
| 42 | A germline variant in the TP53 polyadenylation signal confers cancer susceptibility | Nature Genetics | 2011 | 258 |
| 43 | De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis of current clinical trials | European Journal of Cancer | 2014 | 255 |
| 44 | Mechanisms of metabolic dysfunction in cancer-associated cachexia | Genes and Development | 2016 | 253 |
| 45 | Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy | Lancet Oncology, The | 2007 | 249 |
| 46 | Malignant Germ Cell Tumors Display Common MicroRNA Profiles Resulting in Global Changes in Expression of Messenger RNA Targets | Cancer Research | 2010 | 249 |
| 47 | Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study | Radiotherapy and Oncology | 2016 | 246 |
| 48 | Model of the early development of diffuse gastric cancer in E‐cadherin mutation carriers and its implications for patient screening | Journal of Pathology | 2004 | 243 |
| 49 | TP53 Mutation Spectrum in Breast Cancer Is Subtype Specific and Has Distinct Prognostic Relevance | Clinical Cancer Research | 2014 | 243 |
| 50 | PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes | Annals of Oncology | 2015 | 243 |
