| # | Title | Journal | Year | Citations |
|---|
| 1 | Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway | Science | 2013 | 3,305 |
| 2 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 | Cell | 2005 | 2,839 |
| 3 | Functional Classification and Experimental Dissection of Long Noncoding RNAs | Cell | 2018 | 2,657 |
| 4 | Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres | Nature | 2002 | 2,232 |
| 5 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy | Nature Reviews Genetics | 2009 | 2,173 |
| 6 | Transient Regenerative Potential of the Neonatal Mouse Heart | Science | 2011 | 2,117 |
| 7 | Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals | Cell | 2007 | 2,026 |
| 8 | TAK1 is a ubiquitin-dependent kinase of MKK and IKK | Nature | 2001 | 1,850 |
| 9 | Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA | Science | 2013 | 1,778 |
| 10 | Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain | Cell | 2000 | 1,707 |
| 11 | Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,637 |
| 12 | The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis | Developmental Cell | 2008 | 1,630 |
| 13 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis | Cell Metabolism | 2005 | 1,514 |
| 14 | Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA | Science | 2007 | 1,504 |
| 15 | STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors | Immunity | 2014 | 1,468 |
| 16 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 17 | A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 1,408 |
| 18 | TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity | Nature | 2007 | 1,405 |
| 19 | Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing | Nature Immunology | 2016 | 1,379 |
| 20 | Myogenic satellite cells: physiology to molecular biology | Journal of Applied Physiology | 2001 | 1,359 |
| 21 | Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21 | Cell Metabolism | 2007 | 1,306 |
| 22 | Cardiac Hypertrophy: The Good, the Bad, and the Ugly | Annual Review of Physiology | 2003 | 1,287 |
| 23 | Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation | Science | 2015 | 1,280 |
| 24 | NFAT Signaling | Cell | 2002 | 1,224 |
| 25 | Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection | Science Signaling | 2009 | 1,165 |
| 26 | Ubiquitin signalling in the NF-κB pathway | Nature Cell Biology | 2005 | 1,092 |
| 27 | Pervasive roles of microRNAs in cardiovascular biology | Nature | 2011 | 1,076 |
| 28 | Heart repair by reprogramming non-myocytes with cardiac transcription factors | Nature | 2012 | 1,044 |
| 29 | RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway | Cell | 2009 | 1,026 |
| 30 | MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response | Cell | 2011 | 1,018 |
| 31 | White Fat Progenitor Cells Reside in the Adipose Vasculature | Science | 2008 | 983 |
| 32 | Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis | Nature | 2012 | 975 |
| 33 | Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids | Annual Review of Immunology | 2014 | 957 |
| 34 | Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation | Nature | 2000 | 953 |
| 35 | Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 945 |
| 36 | STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway | Science Signaling | 2012 | 938 |
| 37 | The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors | Nature Genetics | 2002 | 932 |
| 38 | Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO | Molecular Cell | 2006 | 911 |
| 39 | Gene Regulatory Networks in the Evolution and Development of the Heart | Science | 2006 | 903 |
| 40 | Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects | Science | 2013 | 883 |
| 41 | Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy | Cell | 2002 | 878 |
| 42 | A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance | Developmental Cell | 2009 | 865 |
| 43 | Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer | Genesis | 2002 | 858 |
| 44 | Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses | Science | 2013 | 837 |
| 45 | Deacetylase inhibition promotes the generation and function of regulatory T cells | Nature Medicine | 2007 | 835 |
| 46 | Linking actin dynamics and gene transcription to drive cellular motile functions | Nature Reviews Molecular Cell Biology | 2010 | 829 |
| 47 | Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING | Molecular Cell | 2013 | 819 |
| 48 | Mitochondrial Signaling | Molecular Cell | 2004 | 807 |
| 49 | Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor | Cell | 2001 | 806 |
| 50 | The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer | Journal of Experimental Medicine | 2018 | 786 |
