| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia | New England Journal of Medicine | 2018 | 3,977 |
| 2 | Narcolepsy in orexin Knockout Mice | Cell | 1999 | 3,010 |
| 3 | A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy | Cell | 1998 | 2,410 |
| 4 | Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres | Nature | 2002 | 2,269 |
| 5 | Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers | Journal of the National Cancer Institute | 2005 | 2,217 |
| 6 | The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration | Nature Biotechnology | 2007 | 1,998 |
| 7 | A restricted cell population propagates glioblastoma growth after chemotherapy | Nature | 2012 | 1,997 |
| 8 | Changes in thymic function with age and during the treatment of HIV infection | Nature | 1998 | 1,794 |
| 9 | The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis | Developmental Cell | 2008 | 1,661 |
| 10 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,619 |
| 11 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis | Cell Metabolism | 2005 | 1,557 |
| 12 | A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 1,417 |
| 13 | The history and future of targeting cyclin-dependent kinases in cancer therapy | Nature Reviews Drug Discovery | 2015 | 1,389 |
| 14 | Lung cancer in never smokers — a different disease | Nature Reviews Cancer | 2007 | 1,313 |
| 15 | Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 | Cell | 1999 | 1,200 |
| 16 | Regulation of Fibroblast Growth Factor-23 Signaling by Klotho | Journal of Biological Chemistry | 2006 | 1,199 |
| 17 | Primary age-related tauopathy (PART): a common pathology associated with human aging | Acta Neuropathologica | 2014 | 1,119 |
| 18 | Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis | Science | 1999 | 1,100 |
| 19 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 998 |
| 20 | FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis | Cell | 2007 | 963 |
| 21 | Lactate Metabolism in Human Lung Tumors | Cell | 2017 | 958 |
| 22 | High-throughput oncogene mutation profiling in human cancer | Nature Genetics | 2007 | 935 |
| 23 | LKB1 modulates lung cancer differentiation and metastasis | Nature | 2007 | 929 |
| 24 | Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells | Blood | 2003 | 910 |
| 25 | Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets | Nature Communications | 2015 | 907 |
| 26 | Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion | Nature | 2016 | 880 |
| 27 | A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance | Developmental Cell | 2009 | 878 |
| 28 | An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance | Clinical Cancer Research | 2013 | 875 |
| 29 | Metabolic Heterogeneity in Human Lung Tumors | Cell | 2016 | 865 |
| 30 | DNA damage and repair | Nature | 2003 | 858 |
| 31 | Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors | Oncogene | 2009 | 827 |
| 32 | Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor | Cell | 2001 | 818 |
| 33 | BAP1 loss defines a new class of renal cell carcinoma | Nature Genetics | 2012 | 817 |
| 34 | The Y-Family of DNA Polymerases | Molecular Cell | 2001 | 807 |
| 35 | Radiotherapy and immunotherapy: a beneficial liaison? | Nature Reviews Clinical Oncology | 2017 | 804 |
| 36 | Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry | Blood | 1995 | 788 |
| 37 | Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy | Human Molecular Genetics | 1999 | 766 |
| 38 | Hippo pathway effector Yap promotes cardiac regeneration | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 765 |
| 39 | Absence of cancer–associated changes in human fibroblasts immortalized with telomerase | Nature Genetics | 1999 | 757 |
| 40 | HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein | Cell Host and Microbe | 2007 | 744 |
| 41 | Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells | Circulation | 2002 | 741 |
| 42 | 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas | Nature Medicine | 2012 | 728 |
| 43 | Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis | Cell | 2004 | 720 |
| 44 | HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression | Nature Medicine | 1999 | 717 |
| 45 | A STING-activating nanovaccine for cancer immunotherapy | Nature Nanotechnology | 2017 | 693 |
| 46 | Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21 | Journal of Biological Chemistry | 2007 | 666 |
| 47 | Acute Lung Injury: A Clinical and Molecular Review | Archives of Pathology and Laboratory Medicine | 2016 | 664 |
| 48 | How nucleotide excision repair protects against cancer | Nature Reviews Cancer | 2001 | 663 |
| 49 | Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2016 | 658 |
| 50 | Physiological and Molecular Mechanisms of Lymphocyte Homing | Annual Review of Immunology | 1992 | 639 |
