| # | Title | Journal | Year | Citations |
|---|
| 1 | Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial | Lancet Oncology, The | 2018 | 397 |
| 2 | Prostanoids and prostanoid receptors in signal transduction | International Journal of Biochemistry and Cell Biology | 2004 | 332 |
| 3 | The developing cancer stem-cell model: clinical challenges and opportunities | Lancet Oncology, The | 2012 | 327 |
| 4 | Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients | Cell Stem Cell | 2011 | 291 |
| 5 | Symptomatic Venous Thromboembolism in Cancer Patients Treated With Chemotherapy | Archives of Internal Medicine | 2004 | 222 |
| 6 | Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells | Clinical Cancer Research | 2016 | 211 |
| 7 | Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: A Systematic Review | PLoS ONE | 2014 | 210 |
| 8 | A single‐arm, multicenter, open‐label phase 2 study of lapatinib as the second‐line treatment of patients with locally advanced or metastatic transitional cell carcinoma | Cancer | 2009 | 196 |
| 9 | Final results from a randomized phase 3 study of FOLFIRI ± panitumumab for second-line treatment of metastatic colorectal cancer | Annals of Oncology | 2014 | 182 |
| 10 | Wild-type and mutated IDH1/2 enzymes and therapy responses | Oncogene | 2018 | 169 |
| 11 | Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme | BMC Cancer | 2009 | 166 |
| 12 | Preoperative radiochemotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer (PREOPANC trial): study protocol for a multicentre randomized controlled trial | Trials | 2016 | 131 |
| 13 | Effect of Providing Cancer Patients With the Audiotaped Initial Consultation on Satisfaction, Recall, and Quality of Life: A Randomized, Double-Blind Study | Journal of Clinical Oncology | 2000 | 126 |
| 14 | Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer (PREOPANC-1): A randomized, controlled, multicenter phase III trial. | Journal of Clinical Oncology | 2018 | 120 |
| 15 | PCA-based groupwise image registration for quantitative MRI | Medical Image Analysis | 2016 | 118 |
| 16 | First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with Stage IIB, III, and IVA cervical carcinoma | Cancer | 2005 | 112 |
| 17 | Feasibility and efficacy of high dose conformal radiotherapy for patients with locally advanced pancreatic carcinoma | Cancer | 2000 | 108 |
| 18 | Tumour–stroma interactions in pancreatic ductal adenocarcinoma: Rationale and current evidence for new therapeutic strategies | Cancer Treatment Reviews | 2014 | 108 |
| 19 | Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS) | BMC Surgery | 2008 | 104 |
| 20 | Cancer patients’ coping styles and doctor-patient communication | Psycho-Oncology | 1999 | 101 |
| 21 | Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity | Human Genetics | 2010 | 101 |
| 22 | Coagulation factors VIIa and Xa inhibit apoptosis and anoikis | Oncogene | 2004 | 95 |
| 23 | Risk of second malignancies in long-term survivors of childhood cancer | European Journal of Cancer | 2007 | 90 |
| 24 | Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study | BMJ Open | 2017 | 87 |
| 25 | The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer – a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG) | BMC Cancer | 2014 | 86 |
| 26 | Long-term cause-specific mortality among five-year survivors of childhood cancer | Pediatric Blood and Cancer | 2004 | 84 |
| 27 | Oral ibandronate for the treatment of metastatic bone disease in breast cancer: efficacy and safety results from a randomized, double-blind, placebo-controlled trial | Annals of Oncology | 2004 | 82 |
| 28 | Anthracycline–trastuzumab regimens for HER2/neu-overexpressing breast cancer: current experience and future strategies | Annals of Oncology | 2008 | 82 |
| 29 | Recurrence of Pancreatic Neuroendocrine Tumors and Survival Predicted by Ki67 | Annals of Surgical Oncology | 2018 | 82 |
| 30 | Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience | Langenbeck's Archives of Surgery | 2018 | 80 |
| 31 | Gynecologic Cancer InterGroup (GCIG) Consensus Review for Endometrial Stromal Sarcoma | International Journal of Gynecological Cancer | 2014 | 75 |
| 32 | Deep learning how to fit an intravoxel incoherent motion model to diffusion‐weighted MRI | Magnetic Resonance in Medicine | 2020 | 74 |
| 33 | Intensive care admission of cancer patients: a comparative analysis | Cancer Medicine | 2015 | 70 |
| 34 | Induction Chemotherapy Followed by Resection or Irreversible Electroporation in Locally Advanced Pancreatic Cancer (IMPALA): A Prospective Cohort Study | Annals of Surgical Oncology | 2017 | 70 |
| 35 | The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer | Thrombosis Research | 2017 | 70 |
| 36 | Added value of CA19-9 response in predicting resectability of locally advanced pancreatic cancer following induction chemotherapy | Hpb | 2018 | 69 |
| 37 | Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies | Seminars in Cancer Biology | 2017 | 68 |
| 38 | Association Analysis of Genetic Polymorphisms in Genes Related to Sunitinib Pharmacokinetics, Specifically Clearance of Sunitinib and SU12662 | Clinical Pharmacology and Therapeutics | 2014 | 67 |
| 39 | The effect of spiritual interventions addressing existential themes using a narrative approach on quality of life of cancer patients: a systematic review and meta‐analysis | Psycho-Oncology | 2016 | 67 |
| 40 | Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination | OncoImmunology | 2016 | 67 |
| 41 | Identification of volumetric laser endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation | Gastrointestinal Endoscopy | 2017 | 66 |
| 42 | Genomic landscape of metastatic colorectal cancer | Nature Communications | 2014 | 61 |
| 43 | Inhibitors of mTOR | Oncologist | 2010 | 60 |
| 44 | Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor-Naïve Advanced Pancreatic Neuroendocrine Tumors | Oncologist | 2018 | 59 |
| 45 | Protease‐activated receptor‐1 drives pancreatic cancer progression and chemoresistance | International Journal of Cancer | 2014 | 58 |
| 46 | Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases: the CHARISMA randomized multicenter clinical trial | BMC Cancer | 2015 | 57 |
| 47 | The use of adjuvant chemotherapy for pancreatic cancer varies widely between hospitals: a nationwide population‐based analysis | Cancer Medicine | 2016 | 57 |
| 48 | Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix | | 1997 | 56 |
| 49 | Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial | Cancer Epidemiology Biomarkers and Prevention | 2019 | 56 |
| 50 | Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients | OncoImmunology | 2015 | 55 |
