| # | Title | Journal | Year | Citations |
|---|
| 1 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 2 | Epidemiology of heart failure | European Journal of Heart Failure | 2020 | 948 |
| 3 | Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury | Stem Cell Research | 2013 | 932 |
| 4 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | Lancet, The | 2015 | 562 |
| 5 | The changing epidemiology of congenital heart disease | Nature Reviews Cardiology | 2011 | 556 |
| 6 | Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology | European Journal of Heart Failure | 2018 | 555 |
| 7 | Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium | Stem Cell Research | 2008 | 531 |
| 8 | Prognostic Value of Fractional Flow Reserve | Journal of the American College of Cardiology | 2014 | 513 |
| 9 | Diversity of microRNAs in human and chimpanzee brain | Nature Genetics | 2006 | 457 |
| 10 | Incidence and predictors of short- and long-term complications in pacemaker therapy: The FOLLOWPACE study | Heart Rhythm | 2012 | 437 |
| 11 | A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension | European Heart Journal | 2011 | 427 |
| 12 | Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury | Journal of the American College of Cardiology | 2009 | 422 |
| 13 | Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): a randomised controlled trial | Lancet, The | 2002 | 407 |
| 14 | A Comparison of On-Pump and Off-Pump Coronary Bypass Surgery in Low-Risk Patients | New England Journal of Medicine | 2003 | 389 |
| 15 | Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction | Stem Cell Research | 2011 | 379 |
| 16 | Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease | European Heart Journal | 2005 | 378 |
| 17 | Inhibition of miR-25 improves cardiac contractility in the failing heart | Nature | 2014 | 377 |
| 18 | Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers | European Heart Journal | 2015 | 338 |
| 19 | MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells | Arteriosclerosis, Thrombosis, and Vascular Biology | 2010 | 302 |
| 20 | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation | Nature Genetics | 2015 | 294 |
| 21 | Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking | Cardiovascular Ultrasound | 2007 | 293 |
| 22 | Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry | International Journal of Cardiology | 2007 | 287 |
| 23 | Genome-wide analysis identifies 12 loci influencing human reproductive behavior | Nature Genetics | 2016 | 284 |
| 24 | Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia–reperfusion in vivo | Basic Research in Cardiology | 2012 | 277 |
| 25 | Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology | Nature Protocols | 2009 | 276 |
| 26 | Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation | Nanomedicine: Nanotechnology, Biology, and Medicine | 2017 | 268 |
| 27 | Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension | Nature Genetics | 2016 | 261 |
| 28 | A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial | European Heart Journal | 2015 | 259 |
| 29 | 2019 EACTS Expert Consensus on long-term mechanical circulatory support | European Journal of Cardio-thoracic Surgery | 2019 | 255 |
| 30 | Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects | Diabetologia | 2007 | 246 |
| 31 | Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy | Journal of the American College of Cardiology | 2018 | 242 |
| 32 | Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis | European Heart Journal | 2020 | 239 |
| 33 | Heart failure and chronic obstructive pulmonary disease: An ignored combination? | European Journal of Heart Failure | 2006 | 238 |
| 34 | High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes | Diabetologia | 2012 | 238 |
| 35 | Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease | Atherosclerosis | 2008 | 229 |
| 36 | Microvesicles and exosomes for intracardiac communication | Cardiovascular Research | 2014 | 228 |
| 37 | Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci | American Journal of Human Genetics | 2012 | 227 |
| 38 | Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts | BMJ, The | 2012 | 225 |
| 39 | The innate immune response in reperfused myocardium | Cardiovascular Research | 2012 | 224 |
| 40 | The prevalence of adult congenital heart disease, results from a systematic review and evidence based calculation | American Heart Journal | 2012 | 210 |
| 41 | Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: The Multinational Observational Cohort on Acute Heart Failure (MOCA) study | International Journal of Cardiology | 2013 | 207 |
| 42 | Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial | Lancet, The | 2020 | 205 |
| 43 | The HEART Score for the Assessment of Patients With Chest Pain in the Emergency Department | Critical Pathways in Cardiology | 2013 | 203 |
| 44 | Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women | European Heart Journal | 2008 | 202 |
| 45 | Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy | Circulation | 2011 | 194 |
| 46 | Dominant missense mutations in ABCC9 cause Cantú syndrome | Nature Genetics | 2012 | 184 |
| 47 | Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs | EMBO Molecular Medicine | 2012 | 173 |
| 48 | Spatial multi-omic map of human myocardial infarction | Nature | 2022 | 166 |
| 49 | Big data from electronic health records for early and late translational cardiovascular research: challenges and potential | European Heart Journal | 2018 | 163 |
| 50 | Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN | Advanced Healthcare Materials | 2016 | 158 |
