| # | Title | Journal | Year | Citations |
|---|
| 1 | Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer | New England Journal of Medicine | 2001 | 3,840 |
| 2 | Extended Lymph-Node Dissection for Gastric Cancer | New England Journal of Medicine | 1999 | 1,513 |
| 3 | Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial | Lancet Oncology, The | 2010 | 1,493 |
| 4 | Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2008 | 1,239 |
| 5 | ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making | Annals of Oncology | 2012 | 1,233 |
| 6 | Image-guided cancer surgery using near-infrared fluorescence | Nature Reviews Clinical Oncology | 2013 | 1,121 |
| 7 | Colorectal cancer | Nature Reviews Disease Primers | 2015 | 1,104 |
| 8 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 9 | The TME Trial After a Median Follow-up of 6 Years | Annals of Surgery | 2007 | 1,020 |
| 10 | Gastric cancer | Lancet, The | 2009 | 871 |
| 11 | Extended Lymph Node Dissection for Gastric Cancer: Who May Benefit? Final Results of the Randomized Dutch Gastric Cancer Group Trial | Journal of Clinical Oncology | 2004 | 840 |
| 12 | Late Side Effects of Short-Course Preoperative Radiotherapy Combined With Total Mesorectal Excision for Rectal Cancer: Increased Bowel Dysfunction in Irradiated Patients—A Dutch Colorectal Cancer Group Study | Journal of Clinical Oncology | 2005 | 837 |
| 13 | Genome-wide cell-free DNA fragmentation in patients with cancer | Nature | 2019 | 764 |
| 14 | Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2021 | 739 |
| 15 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
| 16 | Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study | Lancet, The | 2018 | 677 |
| 17 | The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery | Journal of Surgical Oncology | 2011 | 673 |
| 18 | Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial | Journal of Clinical Oncology | 2020 | 665 |
| 19 | Risk factors for anastomotic failure after total mesorectal excision of rectal cancer | British Journal of Surgery | 2005 | 601 |
| 20 | Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains | Nature Genetics | 2012 | 588 |
| 21 | A Conservative and Minimally Invasive Approach to Necrotizing Pancreatitis Improves Outcome | Gastroenterology | 2011 | 584 |
| 22 | Micrometastases and Survival in Stage II Colorectal Cancer | New England Journal of Medicine | 1998 | 557 |
| 23 | Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data | Lancet Oncology, The | 2015 | 461 |
| 24 | Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in The Netherlands | British Journal of Surgery | 2002 | 441 |
| 25 | Saphenous Vein Versus PTFE for Above-Knee Femoropopliteal Bypass. A Review of the Literature | European Journal of Vascular and Endovascular Surgery | 2004 | 436 |
| 26 | Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial | Lancet Oncology, The | 2018 | 397 |
| 27 | Metastatic pattern in colorectal cancer is strongly influenced by histological subtype | Annals of Oncology | 2014 | 355 |
| 28 | EURECCA colorectal: Multidisciplinary management: European consensus conference colon & rectum | European Journal of Cancer | 2014 | 349 |
| 29 | Neoadjuvant chemotherapy for operable breast cancer | British Journal of Surgery | 2007 | 327 |
| 30 | Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics | PLoS Genetics | 2008 | 315 |
| 31 | Aprotinin and transfusion requirements in orthotopic liver transplantation: a multicentre randomised double-blind study | Lancet, The | 2000 | 309 |
| 32 | Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers | British Journal of Cancer | 2005 | 307 |
| 33 | Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial | Annals of Oncology | 2015 | 302 |
| 34 | Systematic review and meta-analysis of the volume–outcome relationship in pancreatic surgery | British Journal of Surgery | 2011 | 301 |
| 35 | Timing and impact of infections in acute pancreatitis | British Journal of Surgery | 2009 | 300 |
| 36 | Latest developments in molecular tracers for fluorescence image-guided cancer surgery | Lancet Oncology, The | 2019 | 291 |
| 37 | Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer | Nature Genetics | 2017 | 289 |
| 38 | Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 279 |
| 39 | Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial | European Journal of Surgical Oncology | 2010 | 279 |
| 40 | Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit | British Journal of Surgery | 2014 | 278 |
| 41 | Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study | Stem Cells Translational Medicine | 2013 | 277 |
| 42 | Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial | Lancet, The | 2015 | 276 |
| 43 | Neoadjuvant Chemoradiotherapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Long-Term Results of the Dutch Randomized PREOPANC Trial | Journal of Clinical Oncology | 2022 | 274 |
| 44 | The Dutch Surgical Colorectal Audit | European Journal of Surgical Oncology | 2013 | 270 |
| 45 | Improved survival and local control after total mesorectal excision or D3 lymphadenectomy in the treatment of primary rectal cancer: an international analysis of 1411 patients | European Journal of Surgical Oncology | 1999 | 269 |
| 46 | Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses | Nature Genetics | 2020 | 265 |
| 47 | A multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study | Lancet Oncology, The | 2007 | 264 |
| 48 | Allogeneic Bone Marrow–Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn’s Disease | Gastroenterology | 2015 | 261 |
| 49 | Imaging for Predicting the Risk Factors—the Circumferential Resection Margin and Nodal Disease—of Local Recurrence in Rectal Cancer: A Meta-Analysis | Seminars in Ultrasound, CT and MRI | 2005 | 260 |
| 50 | Near‐infrared fluorescence‐guided resection of colorectal liver metastases | Cancer | 2013 | 260 |
