| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
| 2 | Persistent epigenetic differences associated with prenatal exposure to famine in humans | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 2,736 |
| 3 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,559 |
| 4 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,855 |
| 5 | Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads | Bioinformatics | 2009 | 1,850 |
| 6 | Tutorial in biostatistics: competing risks and multi‐state models | Statistics in Medicine | 2007 | 1,803 |
| 7 | A comprehensive catalogue of somatic mutations from a human cancer genome | Nature | 2010 | 1,536 |
| 8 | Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial | Lancet Oncology, The | 2010 | 1,524 |
| 9 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,389 |
| 10 | Advanced methods in meta‐analysis: multivariate approach and meta‐regression | Statistics in Medicine | 2002 | 1,373 |
| 11 | Effect of Posterolateral Scar Tissue on Clinical and Echocardiographic Improvement After Cardiac Resynchronization Therapy | Circulation | 2006 | 1,118 |
| 12 | A Perfect Smoother | Analytical Chemistry | 2003 | 1,041 |
| 13 | Mapping copy number variation by population-scale genome sequencing | Nature | 2011 | 1,012 |
| 14 | Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial | Lancet, The | 2010 | 1,004 |
| 15 | A global test for groups of genes: testing association with a clinical outcome | Bioinformatics | 2004 | 930 |
| 16 | Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2021 | 865 |
| 17 | Extended Lymph Node Dissection for Gastric Cancer: Who May Benefit? Final Results of the Randomized Dutch Gastric Cancer Group Trial | Journal of Clinical Oncology | 2004 | 845 |
| 18 | Identification of seven loci affecting mean telomere length and their association with disease | Nature Genetics | 2013 | 830 |
| 19 | Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression | Nature Genetics | 2021 | 769 |
| 20 | Competing risks in epidemiology: possibilities and pitfalls | International Journal of Epidemiology | 2012 | 751 |
| 21 | Prospective assessment of falls in Parkinson's disease | Journal of Neurology | 2001 | 733 |
| 22 | L1 Penalized Estimation in the Cox Proportional Hazards Model | Biometrical Journal | 2010 | 711 |
| 23 | Analyzing gene expression data in terms of gene sets: methodological issues | Bioinformatics | 2007 | 707 |
| 24 | Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2 | Nature Genetics | 2012 | 607 |
| 25 | Impact of Short-Term Preoperative Radiotherapy on Health-Related Quality of Life and Sexual Functioning in Primary Rectal Cancer: Report of a Multicenter Randomized Trial | Journal of Clinical Oncology | 2005 | 590 |
| 26 | Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts | Clinical Cancer Research | 2016 | 581 |
| 27 | Parametric Time Warping | Analytical Chemistry | 2004 | 568 |
| 28 | The transcriptional landscape of age in human peripheral blood | Nature Communications | 2015 | 559 |
| 29 | Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data | Statistics in Medicine | 2010 | 517 |
| 30 | Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies | American Journal of Medicine | 2001 | 514 |
| 31 | DNA methylation signatures link prenatal famine exposure to growth and metabolism | Nature Communications | 2014 | 514 |
| 32 | Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data | Lancet Oncology, The | 2015 | 487 |
| 33 | Validation and updating of predictive logistic regression models: a study on sample size and shrinkage | Statistics in Medicine | 2004 | 464 |
| 34 | Clinical Relevance of BCL2, BCL6, and MYC Rearrangements in Diffuse Large B-Cell Lymphoma | Blood | 1998 | 457 |
| 35 | Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in The Netherlands | British Journal of Surgery | 2002 | 445 |
| 36 | Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial | Lancet Oncology, The | 2018 | 445 |
| 37 | Patients With Curative Resection of cT3-4 Rectal Cancer After Preoperative Radiotherapy or Radiochemotherapy: Does Anybody Benefit From Adjuvant Fluorouracil-Based Chemotherapy? A Trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group | Journal of Clinical Oncology | 2007 | 440 |
| 38 | Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals | PLoS Genetics | 2012 | 428 |
| 39 | Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial | Lancet Oncology, The | 2018 | 419 |
| 40 | An electronic nose in the discrimination of patients with asthma and controls | Journal of Allergy and Clinical Immunology | 2007 | 408 |
| 41 | Disease variants alter transcription factor levels and methylation of their binding sites | Nature Genetics | 2017 | 405 |
| 42 | Inappropriate Implantable Cardioverter-Defibrillator Shocks | Journal of the American College of Cardiology | 2011 | 402 |
| 43 | Exploratory Phase III Study of Paclitaxel and Cisplatin Versus Paclitaxel and Carboplatin in Advanced Ovarian Cancer | Journal of Clinical Oncology | 2000 | 400 |
| 44 | Genome-wide patterns and properties of de novo mutations in humans | Nature Genetics | 2015 | 394 |
| 45 | Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand? | European Journal of Cancer | 2011 | 391 |
| 46 | Overestimation of risk ratios by odds ratios in trials and cohort studies: alternatives to logistic regression | Cmaj | 2012 | 384 |
| 47 | Identification of context-dependent expression quantitative trait loci in whole blood | Nature Genetics | 2017 | 380 |
| 48 | Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation | Blood | 2009 | 372 |
| 49 | No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients | Journal of Clinical Oncology | 2001 | 364 |
| 50 | Ageing, age-related diseases and oxidative stress: What to do next? | Ageing Research Reviews | 2020 | 360 |
