| # | Title | Journal | Year | Citations |
|---|
| 1 | Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity | Science | 2016 | 1,398 |
| 2 | The effect of host genetics on the gut microbiome | Nature Genetics | 2016 | 672 |
| 3 | Human Intestinal Barrier Function in Health and Disease | Clinical and Translational Gastroenterology | 2016 | 569 |
| 4 | Vascular complications in diabetes mellitus: the role of endothelial dysfunction | Clinical Science | 2005 | 537 |
| 5 | Analysis of DNA methylation in cancer: location revisited | Nature Reviews Clinical Oncology | 2018 | 486 |
| 6 | The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine | 2011 | 471 |
| 7 | Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus | Nature Medicine | 2015 | 460 |
| 8 | Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial | BMJ: British Medical Journal | 2010 | 433 |
| 9 | Homeostasis of the gut barrier and potential biomarkers | American Journal of Physiology - Renal Physiology | 2017 | 408 |
| 10 | Infection and inflammation and the coagulation system | Cardiovascular Research | 2003 | 403 |
| 11 | Disease variants alter transcription factor levels and methylation of their binding sites | Nature Genetics | 2017 | 390 |
| 12 | Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study | Atherosclerosis | 2007 | 371 |
| 13 | Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial | Lancet, The | 2017 | 364 |
| 14 | Identification of context-dependent expression quantitative trait loci in whole blood | Nature Genetics | 2017 | 363 |
| 15 | Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State | Arteriosclerosis, Thrombosis, and Vascular Biology | 2013 | 358 |
| 16 | Postcolonoscopy colorectal cancers are preventable: a population-based study | Gut | 2014 | 311 |
| 17 | Chronic kidney disease and premature ageing | Nature Reviews Nephrology | 2014 | 302 |
| 18 | Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression | Lancet Diabetes and Endocrinology,the | 2020 | 294 |
| 19 | Inequities in access to biologic and synthetic DMARDs across 46 European countries | Annals of the Rheumatic Diseases | 2014 | 289 |
| 20 | Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function | Neurogastroenterology and Motility | 2009 | 279 |
| 21 | Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity | Diabetes | 2010 | 274 |
| 22 | Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable | PLoS ONE | 2013 | 260 |
| 23 | VHL and HIF signalling in renal cell carcinogenesis | Journal of Pathology | 2010 | 258 |
| 24 | High temporal and inter‐individual variation detected in the human ileal microbiota | Environmental Microbiology | 2010 | 254 |
| 25 | Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomised controlled trial | Lancet, The | 2017 | 253 |
| 26 | Post-Colonoscopy Complications: A Systematic Review, Time Trends, and Meta-Analysis of Population-Based Studies | American Journal of Gastroenterology | 2016 | 252 |
| 27 | Platelet‐ and erythrocyte‐derived microparticles trigger thrombin generation via factor XIIa | Journal of Thrombosis and Haemostasis | 2012 | 243 |
| 28 | The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases | Clinical Science | 2015 | 241 |
| 29 | DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis | Lancet Oncology, The | 2018 | 238 |
| 30 | Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in Patients with Multiple Sclerosis | PLoS ONE | 2009 | 235 |
| 31 | The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings | Annals of Oncology | 2013 | 232 |
| 32 | Characteristics of triple-negative breast cancer | Journal of Cancer Research and Clinical Oncology | 2011 | 225 |
| 33 | Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial | Lancet Respiratory Medicine,the | 2018 | 219 |
| 34 | Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer | JAMA Oncology | 2021 | 217 |
| 35 | Breast Cancer Prognosis and Occult Lymph Node Metastases, Isolated Tumor Cells, and Micrometastases | Journal of the National Cancer Institute | 2010 | 215 |
| 36 | Endothelial Dysfunction Contributes to Renal Function–Associated Cardiovascular Mortality in a Population with Mild Renal Insufficiency: The Hoorn Study | Journal of the American Society of Nephrology: JASN | 2006 | 212 |
| 37 | Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine | Annals of the Rheumatic Diseases | 2009 | 212 |
| 38 | Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions | Cell Metabolism | 2010 | 212 |
| 39 | ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update | Annals of the Rheumatic Diseases | 2023 | 212 |
| 40 | Effects of vitamin D on the peripheral adaptive immune system: A review | Autoimmunity Reviews | 2011 | 207 |
| 41 | Afamelanotide for Erythropoietic Protoporphyria | New England Journal of Medicine | 2015 | 206 |
| 42 | Methylation ofTFPI2in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer | Cancer Research | 2009 | 204 |
| 43 | Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes | Diabetes Care | 2011 | 202 |
| 44 | Long-term follow-up on effectiveness and safety of etanercept in juvenile idiopathic arthritis: the Dutch national register | Annals of the Rheumatic Diseases | 2009 | 196 |
| 45 | Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study | Diabetologia | 2016 | 196 |
| 46 | Spinal Cord Stimulation and Pain Relief in Painful Diabetic Peripheral Neuropathy: A Prospective Two-Center Randomized Controlled Trial | Diabetes Care | 2014 | 193 |
| 47 | Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats | Journal of Biological Chemistry | 2011 | 189 |
| 48 | Early Atherosclerosis Exhibits an Enhanced Procoagulant State | Circulation | 2010 | 183 |
| 49 | Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study | Journal of the American Society of Nephrology: JASN | 2007 | 182 |
| 50 | Leaky gut and diabetes mellitus: what is the link? | Obesity Reviews | 2011 | 182 |
