| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Global Epigenomic Reconfiguration During Mammalian Brain Development | Science | 2013 | 1,645 |
| 2 | The −308 tumor necrosis factor-α promoter polymorphism effects transcription | Molecular Immunology | 1997 | 838 |
| 3 | Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015 | 743 |
| 4 | Metabolic depression in animals: physiological perspectives and biochemical generalizations | Biological Reviews | 1999 | 628 |
| 5 | Energy frameworks: insights into interaction anisotropy and the mechanical properties of molecular crystals | Chemical Communications | 2015 | 557 |
| 6 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 547 |
| 7 | Cancer metabolism: facts, fantasy, and fiction | Biochemical and Biophysical Research Communications | 2004 | 531 |
| 8 | The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases | Immunological Reviews | 1999 | 508 |
| 9 | Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases | Microbiology and Molecular Biology Reviews | 2006 | 496 |
| 10 | A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins | PLoS Genetics | 2012 | 468 |
| 11 | Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production | Microbial Cell Factories | 2012 | 457 |
| 12 | Volume and Frequency of Breastfeedings and Fat Content of Breast Milk Throughout the Day | Pediatrics | 2006 | 443 |
| 13 | Analysis of the Arabidopsis Mitochondrial Proteome | Plant Physiology | 2001 | 433 |
| 14 | Oval Cell Numbers in Human Chronic Liver Diseases Are Directly Related to Disease Severity | American Journal of Pathology | 1999 | 419 |
| 15 | Accurate and Efficient Model Energies for Exploring Intermolecular Interactions in Molecular Crystals | Journal of Physical Chemistry Letters | 2014 | 418 |
| 16 | The Absence of ALTERNATIVE OXIDASE1a in Arabidopsis Results in Acute Sensitivity to Combined Light and Drought Stress | Plant Physiology | 2008 | 367 |
| 17 | Rice cytochrome P450 MAX1 homologs catalyze distinct steps in strigolactone biosynthesis | Nature Chemical Biology | 2014 | 353 |
| 18 | Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease | Journal of Leukocyte Biology | 1999 | 324 |
| 19 | Ground-level ozone in four Chinese cities: precursors, regional transport and heterogeneous processes | Atmospheric Chemistry and Physics | 2014 | 322 |
| 20 | Variation in fat, lactose and protein in human milk over 24h and throughout the first year of lactation | British Journal of Nutrition | 2002 | 315 |
| 21 | Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization | Journal of Cell Biology | 2016 | 287 |
| 22 | Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles | Journal of Cell Biology | 2015 | 286 |
| 23 | Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice | Journal of Experimental Medicine | 2000 | 281 |
| 24 | Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants | Plant Journal | 2016 | 278 |
| 25 | Strigolactone Hormones and Their Stereoisomers Signal through Two Related Receptor Proteins to Induce Different Physiological Responses in Arabidopsis | Plant Physiology | 2014 | 268 |
| 26 | Physiological and Transcriptome Analysis of Iron and Phosphorus Interaction in Rice Seedlings | Plant Physiology | 2009 | 266 |
| 27 | Salicylic Acid Is an Uncoupler and Inhibitor of Mitochondrial Electron Transport | Plant Physiology | 2004 | 259 |
| 28 | In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1 | FASEB Journal | 2012 | 257 |
| 29 | Regulation of Seed Germination and Seedling Growth by Chemical Signals from Burning Vegetation | Annual Review of Plant Biology | 2012 | 255 |
| 30 | Progesterone synthesis by the human placenta | Placenta | 2005 | 254 |
| 31 | Novel activities of CYP11A1 and their potential physiological significance | Journal of Steroid Biochemistry and Molecular Biology | 2015 | 253 |
| 32 | Ultrasound Imaging of Milk Ejection in the Breast of Lactating Women | Pediatrics | 2004 | 247 |
| 33 | Effects of Water Stress on Respiration in Soybean Leaves | Plant Physiology | 2005 | 246 |
| 34 | RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20‐hydroxy‐ and 20,23‐dihydroxyvitamin D | FASEB Journal | 2014 | 246 |
| 35 | Low Free Testosterone Predicts Frailty in Older Men: The Health in Men Study | Journal of Clinical Endocrinology and Metabolism | 2010 | 245 |
| 36 | The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs) | International Journal of Biochemistry and Cell Biology | 2001 | 236 |
| 37 | Differential Impact of Environmental Stresses on the Pea Mitochondrial Proteome | Molecular and Cellular Proteomics | 2005 | 233 |
| 38 | Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2004 | 232 |
| 39 | Lower Testosterone Levels Predict Incident Stroke and Transient Ischemic Attack in Older Men | Journal of Clinical Endocrinology and Metabolism | 2009 | 231 |
| 40 | TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα | Journal of Cell Biology | 2008 | 229 |
| 41 | Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells | Biochemical Journal | 2002 | 228 |
| 42 | LATERAL BRANCHING OXIDOREDUCTASEacts in the final stages of strigolactone biosynthesis inArabidopsis | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 227 |
| 43 | Hydrogen atoms can be located accurately and precisely by x-ray crystallography | Science Advances | 2016 | 226 |
| 44 | Increased Cerebral Glucose-6-Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress | Journal of Neurochemistry | 1986 | 225 |
| 45 | Breastmilk Is a Novel Source of Stem Cells with Multilineage Differentiation Potential | Stem Cells | 2012 | 222 |
| 46 | Maintenance of villus height and crypt depth, and enhancement of disaccharide digestion and monosaccharide absorption, in piglets fed on cows' whole milk after weaning | British Journal of Nutrition | 1996 | 221 |
| 47 | The emergence of sulfoxides as efficient ligands in transition metal catalysis | Chemical Society Reviews | 2015 | 219 |
| 48 | The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold | Nucleic Acids Research | 2016 | 219 |
| 49 | Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma | Carcinogenesis | 2002 | 214 |
| 50 | Anatomy of the lactating human breast redefined with ultrasound imaging | Journal of Anatomy | 2005 | 214 |
