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Top Articles

#TitleJournalYearCitations
1LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK CellsCell Metabolism20161,218
2Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research ConsortiumLancet Infectious Diseases, The20191,083
3Wnt/β-catenin signaling controls development of the blood–brain barrierJournal of Cell Biology2008706
4Ubiquitination and selective autophagyCell Death and Differentiation2013607
5Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondriaProceedings of the National Academy of Sciences of the United States of America2016583
6Infarct Remodeling After Intracoronary Progenitor Cell Treatment in Patients With Acute Myocardial Infarction (TOPCARE-AMI)Circulation2003541
7Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cellsNature2015521
8Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cellsBlood2006508
9Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapiesBlood2012426
10The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19European Respiratory Journal2020421
11Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation (SORMAIN)Journal of Clinical Oncology2020369
12An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemiaBlood2008368
13Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell DormancyCell2017358
14Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study GroupJournal of Clinical Oncology2009345
15European Evidence-based Consensus: Inflammatory Bowel Disease and MalignanciesJournal of Crohn's and Colitis2015342
16Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart FailureJAMA Cardiology2019336
17Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17pBlood2012332
18Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantationLancet Oncology, The2014332
19High Levels of Wilms' Tumor Gene (wt1) mRNA in Acute Myeloid Leukemias Are Associated With a Worse Long-Term OutcomeBlood1997321
20A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene AnalysisMolecular Therapy2008319
21Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL)Blood2006312
22Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimeticProceedings of the National Academy of Sciences of the United States of America2006312
23Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008Leukemia2010307
24The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95Blood2004306
25Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione SynthesisCancer Research2014299
26A multiprotein supercomplex controlling oncogenic signalling in lymphomaNature2018295
27Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling OutcomesMolecular Cell2009285
28Risk of recurrent venous thrombosis in children with combined prothrombotic risk factorsBlood2001272
29Cerebral Venous Thrombosis in ChildrenCirculation2003270
30Long-Term Outcome in Children With Relapsed Acute Lymphoblastic Leukemia After Time-Point and Site-of-Relapse Stratification and Intensified Short-Course Multidrug Chemotherapy: Results of Trial ALL-REZ BFM 90Journal of Clinical Oncology2010269
31Next-generation sequencing and real-time quantitative PCR for minimal residual disease detection in B-cell disordersLeukemia2014265
32Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990Leukemia2000258
33Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALLBlood2016258
34Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine TissuesMolecular and Cellular Proteomics2012249
35Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironmentBlood2017248
36Gene therapy with adeno-associated virus vector 5–human factor IX in adults with hemophilia BBlood2018242
37Cellular Immunotherapy of Malignancies Using the Clonal Natural Killer Cell Line NK-92Journal of Hematotherapy and Stem Cell Research2001232
38Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironmentOncoImmunology2015232
39Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trialsBlood2007227
40Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)Blood2007227
41Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic LeukemiaCancer Cell2016224
42Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort studyBlood2007223
43Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trialLancet Oncology, The2018216
44Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenaseLeukemia2011215
45Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacyClinical Research in Cardiology2011213
46Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93Leukemia2004206
47Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapyProceedings of the National Academy of Sciences of the United States of America2006205
48CD19‐CAR engineered NK‐92 cells are sufficient to overcome NK cell resistance in B‐cell malignanciesJournal of Cellular and Molecular Medicine2016202
49Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemiaNature Medicine2017197
50Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutationsBlood2013186