| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 2 | Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders | JAMA Psychiatry | 2017 | 186 |
| 3 | Mapping 123 million neonatal, infant and child deaths between 2000 and 2017 | Nature | 2019 | 161 |
| 4 | Structured crowdsourcing enables convolutional segmentation of histology images | Bioinformatics | 2019 | 151 |
| 5 | Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections | Journal of Hepatology | 1997 | 121 |
| 6 | Characterizing the morbid genome of ciliopathies | Genome Biology | 2016 | 118 |
| 7 | Recessive Mutations in DOCK6, Encoding the Guanidine Nucleotide Exchange Factor DOCK6, Lead to Abnormal Actin Cytoskeleton Organization and Adams-Oliver Syndrome | American Journal of Human Genetics | 2011 | 115 |
| 8 | Electrospun cellulose acetate nanofiber incorporated with hydroxyapatite for removal of heavy metals | International Journal of Biological Macromolecules | 2020 | 105 |
| 9 | Risk Classification Systems for Drug Use During Pregnancy | Drug Safety | 2000 | 104 |
| 10 | Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways | Hepatology | 2009 | 91 |
| 11 | Hepato-renal toxicity of oral sub-chronic exposure to aluminum oxide and/or zinc oxide nanoparticles in rats | Toxicology Reports | 2019 | 90 |
| 12 | Loop-mediated isothermal amplification (LAMP) for malarial parasites of humans: Would it come to clinical reality as a point-of-care test? | Acta Tropica | 2012 | 89 |
| 13 | Assessment of parathyroid autotransplantation for preservation of parathyroid function after total thyroidectomy | Head and Neck | 2003 | 84 |
| 14 | Chitosan and silver nanoparticles: Promising anti-toxoplasma agents | Experimental Parasitology | 2014 | 77 |
| 15 | Diagnostic Exome Sequencing to Elucidate the Genetic Basis of Likely Recessive Disorders in Consanguineous Families | Human Mutation | 2014 | 75 |
| 16 | Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth | Virology | 2005 | 73 |
| 17 | Electrospun nanofibers hybrid composites membranes for highly efficient antibacterial activity | Ecotoxicology and Environmental Safety | 2018 | 73 |
| 18 | Intracellular GSH content and HIV replication in human macrophages | Journal of Leukocyte Biology | 1997 | 71 |
| 19 | Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial | Age and Ageing | 2012 | 68 |
| 20 | The morbid genome of ciliopathies: an update | Genetics in Medicine | 2020 | 68 |
| 21 | Phenotype and genotype of 87 patients with Mowat–Wilson syndrome and recommendations for care | Genetics in Medicine | 2018 | 67 |
| 22 | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up | Frontiers in Nutrition | 2018 | 67 |
| 23 | Consanguinity and advanced maternal age as risk factors for reproductive losses in Alexandria, Egypt | European Journal of Epidemiology | 2001 | 64 |
| 24 | The combined effect of metformin and l-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats | European Journal of Pharmacology | 2013 | 63 |
| 25 | Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice | European Journal of Pharmaceutics and Biopharmaceutics | 2014 | 62 |
| 26 | Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder | Journal of Neuroimmunology | 2019 | 62 |
| 27 | Risk factors for congenital heart diseases in Alexandria, Egypt | European Journal of Epidemiology | 2000 | 59 |
| 28 | Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells | Cellular Signalling | 2004 | 58 |
| 29 | Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer | Journal of Cancer Research and Clinical Oncology | 2017 | 58 |
| 30 | Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats | Journal of Physiology and Biochemistry | 2011 | 57 |
| 31 | Stannous chloride induces alterations in enzyme activities, lipid peroxidation and histopathology in male rabbit: Antioxidant role of vitamin C | Food and Chemical Toxicology | 2005 | 56 |
| 32 | Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: Erythropoietin versus curcumin | European Journal of Pharmacology | 2016 | 56 |
| 33 | Effects of Silver Nanoparticles on Burn Wound Healing in a Mouse Model | Biological Trace Element Research | 2020 | 52 |
| 34 | A molecular approach for identification of paramphistomes from Africa and Asia | Veterinary Parasitology | 2010 | 50 |
| 35 | Development of immunization trials against Eimeria spp. | Trials in Vaccinology | 2016 | 50 |
| 36 | Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort | Journal of Medical Genetics | 2020 | 50 |
| 37 | Mammographic and sonographic features of tuberculous mastitis | European Journal of Radiology | 2004 | 49 |
| 38 | Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans | European Journal of Nutrition | 2017 | 49 |
| 39 | Dysautonomia: An Overlooked Neurological Manifestation in a Critically ill COVID-19 Patient | American Journal of the Medical Sciences | 2020 | 49 |
| 40 | Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats | European Journal of Pharmacology | 2013 | 48 |
| 41 | Barriers to breast cancer screening among a sample of Egyptian females | Journal of Family and Community Medicine | 2014 | 48 |
| 42 | Development of immunization trials against Acinetobacter baumannii | Trials in Vaccinology | 2016 | 48 |
| 43 | Identification of the Egyptian species of Fasciola | Veterinary Parasitology | 2002 | 47 |
| 44 | Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis | Journal of Controlled Release | 2017 | 47 |
| 45 | Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF) | Nutritional Neuroscience | 2021 | 47 |
| 46 | Hybrid bioactive hydroxyapatite/polycaprolactone nanoparticles for enhanced osteogenesis | Materials Science and Engineering C | 2021 | 47 |
| 47 | Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells | Endocrine | 2015 | 46 |
| 48 | Expanding the phenome and variome of skeletal dysplasia | Genetics in Medicine | 2018 | 46 |
| 49 | On the phenotypic spectrum of serine biosynthesis defects | Journal of Inherited Metabolic Disease | 2016 | 45 |
| 50 | Erector spinae versus paravertebral plane blocks in modified radical mastectomy: Randomised comparative study of the technique success rate among novice anaesthesiologists | Indian Journal of Anaesthesia | 2020 | 45 |
