| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 2 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 3 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 5 | Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs | Drug Discovery Today | 2007 | 1,262 |
| 6 | Medication Adherence Measures: An Overview | BioMed Research International | 2015 | 710 |
| 7 | Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery | International Journal of Pharmaceutics | 2004 | 572 |
| 8 | Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species | Journal of Medical Microbiology | 2009 | 523 |
| 9 | Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery | Pharmaceutical Research | 2007 | 522 |
| 10 | Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758) | Aquatic Toxicology | 2018 | 471 |
| 11 | Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals | Science of the Total Environment | 2013 | 469 |
| 12 | Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies | Carbohydrate Polymers | 2006 | 428 |
| 13 | Solid-phase microextraction: a promising technique for sample preparation in environmental analysis | Journal of Chromatography A | 2000 | 405 |
| 14 | Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review | Phytotherapy Research | 2018 | 400 |
| 15 | Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine | ACS Nano | 2016 | 397 |
| 16 | Toxicity of amphetamines: an update | Archives of Toxicology | 2012 | 364 |
| 17 | Emergence and spread of vancomycin resistance among enterococci in Europe | Eurosurveillance | 2008 | 358 |
| 18 | Phenolic compounds: current industrial applications, limitations and future challenges | Food and Function | 2021 | 318 |
| 19 | Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach | Toxicology Letters | 2014 | 317 |
| 20 | Mycotoxins in cereals and related foodstuffs: A review on occurrence and recent methods of analysis | Trends in Food Science and Technology | 2014 | 300 |
| 21 | Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy | | 2015 | 275 |
| 22 | α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure–activity relationship study | Journal of Enzyme Inhibition and Medicinal Chemistry | 2017 | 274 |
| 23 | Paraquat exposure as an etiological factor of Parkinson's disease | NeuroToxicology | 2006 | 273 |
| 24 | Khat and synthetic cathinones: a review | Archives of Toxicology | 2014 | 273 |
| 25 | Optical sensors and biosensors based on sol–gel films | Talanta | 2007 | 266 |
| 26 | Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review) | International Journal of Molecular Medicine | 2020 | 261 |
| 27 | Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview | Molecular Neurobiology | 2009 | 251 |
| 28 | Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species | Journal of Medical Microbiology | 2006 | 249 |
| 29 | Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. | Food and Chemical Toxicology | 2010 | 243 |
| 30 | Effects of multi-stressors on juveniles of the marine fish Pomatoschistus microps: Gold nanoparticles, microplastics and temperature | Aquatic Toxicology | 2016 | 238 |
| 31 | Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles | Biomacromolecules | 2007 | 236 |
| 32 | Biochemical impact of a soccer match — analysis of oxidative stress and muscle damage markers throughout recovery | Clinical Biochemistry | 2008 | 233 |
| 33 | Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii | Aquatic Toxicology | 2018 | 230 |
| 34 | Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal) | Journal of Ethnopharmacology | 2009 | 228 |
| 35 | Nanotechnological carriers for cancer chemotherapy: The state of the art | Colloids and Surfaces B: Biointerfaces | 2015 | 228 |
| 36 | Metabolomics Analysis for Biomarker Discovery: Advances and Challenges | Current Medicinal Chemistry | 2013 | 226 |
| 37 | Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound | Colloids and Surfaces B: Biointerfaces | 2011 | 222 |
| 38 | Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease | Molecules | 2017 | 222 |
| 39 | Interventional tools to improve medication adherence: review of literature | Patient Preference and Adherence | 2015 | 221 |
| 40 | Old Drugs as New Treatments for Neurodegenerative Diseases | Pharmaceuticals | 2018 | 213 |
| 41 | Development and characterization of new insulin containing polysaccharide nanoparticles | Colloids and Surfaces B: Biointerfaces | 2006 | 212 |
| 42 | Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα | Blood | 2008 | 212 |
| 43 | Gels as vaginal drug delivery systems | International Journal of Pharmaceutics | 2006 | 210 |
| 44 | Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles | International Journal of Nanomedicine | 2007 | 210 |
| 45 | Ficus carica L.: Metabolic and biological screening | Food and Chemical Toxicology | 2009 | 204 |
| 46 | Insulin-Loaded Nanoparticles are Prepared by Alginate Ionotropic Pre-Gelation Followed by Chitosan Polyelectrolyte Complexation | Journal of Nanoscience and Nanotechnology | 2007 | 200 |
| 47 | Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation | Basic and Clinical Pharmacology and Toxicology | 2015 | 193 |
| 48 | Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations | European Journal of Pharmaceutics and Biopharmaceutics | 2004 | 190 |
| 49 | Polymer-based nanoparticles for oral insulin delivery: Revisited approaches | Biotechnology Advances | 2015 | 189 |
| 50 | Global Mortality From Firearms, 1990-2016 | JAMA - Journal of the American Medical Association | 2018 | 189 |
