| # | Title | Journal | Year | Citations |
|---|
| 1 | Targeting the cancer epigenome for therapy | Nature Reviews Genetics | 2016 | 888 |
| 2 | DNA methylation aging clocks: challenges and recommendations | Genome Biology | 2019 | 552 |
| 3 | Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019 | Chest | 2020 | 531 |
| 4 | Adipose tissue inflammation and metabolic dysfunction in obesity | American Journal of Physiology - Cell Physiology | 2021 | 510 |
| 5 | Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. The 2020 GOLD Science Committee Report on COVID-19 and Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2021 | 417 |
| 6 | Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis | PLoS Medicine | 2017 | 401 |
| 7 | Development and Validation of the Rome IV Diagnostic Questionnaire for Adults | Gastroenterology | 2016 | 400 |
| 8 | Precision editing of the gut microbiota ameliorates colitis | Nature | 2018 | 377 |
| 9 | Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology | Cardiovascular Research | 2018 | 284 |
| 10 | Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis | Nature Communications | 2019 | 280 |
| 11 | Metabolic Coordination of Physiological and Pathological Cardiac Remodeling | Circulation Research | 2018 | 232 |
| 12 | T Cell Dysfunction and Exhaustion in Cancer | Frontiers in Cell and Developmental Biology | 2020 | 226 |
| 13 | Glycogen synthase kinase-3 signaling in Alzheimer's disease | Biochimica Et Biophysica Acta - Molecular Cell Research | 2020 | 225 |
| 14 | New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging | Frontiers in Pharmacology | 2018 | 199 |
| 15 | Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models | Molecular Neurobiology | 2019 | 186 |
| 16 | Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity | Molecular Cell | 2017 | 179 |
| 17 | Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth | Blood | 2017 | 175 |
| 18 | AT1 receptor signaling pathways in the cardiovascular system | Pharmacological Research | 2017 | 157 |
| 19 | Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control | Frontiers in Physiology | 2018 | 154 |
| 20 | Diet, Nutrition, and Cancer Epigenetics | Annual Review of Nutrition | 2016 | 146 |
| 21 | Compartmentalised acyl-CoA metabolism and roles in chromatin regulation | Molecular Metabolism | 2020 | 146 |
| 22 | M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment | Basic Research in Cardiology | 2020 | 144 |
| 23 | Clinical and translational advances in esophageal squamous cell carcinoma | Advances in Cancer Research | 2019 | 140 |
| 24 | Na+ controls hypoxic signalling by the mitochondrial respiratory chain | Nature | 2020 | 139 |
| 25 | Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology | Hypertension | 2018 | 136 |
| 26 | Innate-adaptive immunity interplay and redox regulation in immune response | Redox Biology | 2020 | 129 |
| 27 | Single and combined effects of Δ9‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain | British Journal of Pharmacology | 2017 | 126 |
| 28 | Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease | Frontiers in Cardiovascular Medicine | 2017 | 125 |
| 29 | An Updated Definition and Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbations: The Rome Proposal | American Journal of Respiratory and Critical Care Medicine | 2021 | 121 |
| 30 | HIV-1–Associated Atherosclerosis | Journal of the American College of Cardiology | 2017 | 119 |
| 31 | Psychopathology, disordered eating, and impulsivity as predictors of outcomes of bariatric surgery | Surgery for Obesity and Related Diseases | 2019 | 119 |
| 32 | From GOLD 0 to Pre-COPD | American Journal of Respiratory and Critical Care Medicine | 2021 | 119 |
| 33 | Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors | Journal of Experimental Medicine | 2018 | 117 |
| 34 | SARS–CoV‐2 Infection and COVID‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis | Arthritis and Rheumatology | 2022 | 117 |
| 35 | International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer—incorporation of surgical, laryngeal, and neural electrophysiologic data | Laryngoscope | 2018 | 111 |
| 36 | Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease. Is There a Pulmonary Vascular Phenotype? | American Journal of Respiratory and Critical Care Medicine | 2018 | 111 |
| 37 | Noninvasive Imaging Biomarker Identifies Small Airway Damage in Severe Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2019 | 110 |
| 38 | Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications | Microbiology and Molecular Biology Reviews | 2018 | 108 |
| 39 | Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis | Cancer Cell | 2019 | 107 |
| 40 | Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics | | 2021 | 105 |
| 41 | Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis | Cardiovascular Research | 2017 | 101 |
| 42 | HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity | Cell Death and Disease | 2018 | 99 |
| 43 | Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications | Annual Review of Pathology: Mechanisms of Disease | 2017 | 98 |
| 44 | Disease drivers of aging | Annals of the New York Academy of Sciences | 2016 | 97 |
| 45 | Interleukin-10 Deficiency Alters Endothelial Progenitor Cell–Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment | Circulation Research | 2020 | 97 |
| 46 | Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 97 |
| 47 | Calming the cytokine storm in COVID-19 | Nature Medicine | 2021 | 97 |
| 48 | To mdivi‐1 or not to mdivi‐1: Is that the question? | Developmental Neurobiology | 2017 | 93 |
| 49 | Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers | Scientific Reports | 2016 | 92 |
| 50 | The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure | Molecular Psychiatry | 2020 | 92 |
