| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency | New England Journal of Medicine | 1997 | 1,069 |
| 2 | Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells | Nature Medicine | 2006 | 593 |
| 3 | Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women | Journal of the American College of Cardiology | 2002 | 528 |
| 4 | Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease | Gastroenterology | 2004 | 433 |
| 5 | The ferroportin disease | Blood Cells, Molecules, and Diseases | 2004 | 337 |
| 6 | Dysmetabolic Syndrome in a Man with a Novel Mutation of the Aromatase Gene: Effects of Testosterone, Alendronate, and Estradiol Treatment | Journal of Clinical Endocrinology and Metabolism | 2004 | 315 |
| 7 | STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo | Gastroenterology | 2007 | 279 |
| 8 | Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload | Gastroenterology | 2001 | 267 |
| 9 | Muir-Torre syndrome | Lancet Oncology, The | 2005 | 266 |
| 10 | Iron regulatory proteins in pathobiology | Biochemical Journal | 2000 | 261 |
| 11 | Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription | Gastroenterology | 2008 | 242 |
| 12 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years | Gastroenterology | 2004 | 232 |
| 13 | Extrahepatic manifestations of Hepatitis C Virus infection: A general overview and guidelines for a clinical approach | Digestive and Liver Disease | 2007 | 222 |
| 14 | Natural history of inoperable hepatocellular carcinoma: Estrogen receptors' status in the tumor is the strongest prognostic factor for survival | Hepatology | 2000 | 215 |
| 15 | The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability | Nature Genetics | 1999 | 211 |
| 16 | Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene | Journal of Clinical Investigation | 2001 | 207 |
| 17 | Memory rehabilitation in Alzheimer's disease: a review of progress | International Journal of Geriatric Psychiatry | 2001 | 206 |
| 18 | Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: A meta-analysis of individual patient data | Hepatology | 2004 | 198 |
| 19 | Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations | Acta Neuropathologica | 2018 | 196 |
| 20 | Hemochromatosis: An endocrine liver disease | Hepatology | 2007 | 193 |
| 21 | Iron, oxidative stress and liver fibrogenesis | Journal of Hepatology | 1998 | 176 |
| 22 | Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience | Clinical Endocrinology | 2007 | 164 |
| 23 | Metals, Oxidative Stress, and Hepatic Fibrogenesis | Seminars in Liver Disease | 1996 | 163 |
| 24 | The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal. | Free Radical Biology and Medicine | 2002 | 160 |
| 25 | Prevalence of the Y165C, G382D and 1395delGGA germline mutations of theMYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas | International Journal of Cancer | 2004 | 159 |
| 26 | The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression | Journal of Hepatology | 2003 | 154 |
| 27 | The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain | European Journal of Pharmacology | 1996 | 150 |
| 28 | Mitochondrial Membrane Potential and DNA Stainability in Human Sperm Cells: A Flow Cytometry Analysis with Implications for Male Infertility | Experimental Cell Research | 1998 | 147 |
| 29 | Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis | Blood | 2000 | 140 |
| 30 | Estrogen Replacement Therapy in a Man with Congenital Aromatase Deficiency: Effects of Different Doses of Transdermal Estradiol on Bone Mineral Density and Hormonal Parameters | Journal of Clinical Endocrinology and Metabolism | 2000 | 137 |
| 31 | Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas | Cancer | 2005 | 136 |
| 32 | Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field | International Journal of Developmental Neuroscience | 1998 | 131 |
| 33 | Natural history of gallstone disease: Expectant management or active treatment? Results from a population‐based cohort study | Journal of Gastroenterology and Hepatology (Australia) | 2010 | 130 |
| 34 | Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes | Gastroenterology | 2005 | 129 |
| 35 | Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. | Journal of Clinical Investigation | 1995 | 126 |
| 36 | Peptide plasticity in primary sensory neurons and spinal cord during adjuvant-induced arthritis in the rat: an immunocytochemical and in situ hybridization study | Neuroscience | 1997 | 122 |
| 37 | Oestrogen deficiency in men: where are we today? | European Journal of Endocrinology | 1999 | 121 |
| 38 | Effects of Selective Serotonin Reuptake Inhibitor Therapy on Endothelial Function and Inflammatory Markers in Patients With Coronary Heart Disease | Clinical Pharmacology and Therapeutics | 2009 | 121 |
| 39 | Statins in liver disease: A molehill, an iceberg, or neither? | Hepatology | 2008 | 117 |
| 40 | Non-HFE hemochromatosis | Hepatology | 2004 | 116 |
| 41 | Hepatitis C Virus Infection: Evidence for an association with type 2 diabetes | Diabetes Care | 2005 | 114 |
| 42 | Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool | Gastroenterology | 1996 | 107 |
| 43 | Liver Angiopoietin‐2 Is a Key Predictor of D e N ovo or Recurrent Hepatocellular Cancer After Hepatitis C Virus Direct‐Acting Antivirals | Hepatology | 2018 | 106 |
| 44 | Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics | Cell Proliferation | 2000 | 105 |
| 45 | Infliximab-related hepatitis: discussion of a case and review of the literature | Internal and Emergency Medicine | 2010 | 105 |
| 46 | Naloxone-reversible antinociception by paracetamol in the rat | Journal of Pharmacology and Experimental Therapeutics | 1997 | 105 |
| 47 | Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study | Annals of the Rheumatic Diseases | 2012 | 104 |
| 48 | Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency | Clinical Endocrinology | 1999 | 103 |
| 49 | Left atrial size is the major predictor of cardiac death and overall clinical outcome in patients with dilated cardiomyopathy: A long‐term follow‐up study | Clinical Cardiology | 1997 | 102 |
| 50 | Molecular Screening for Hereditary Nonpolyposis Colorectal Cancer: A Prospective, Population-Based Study | Journal of Clinical Oncology | 2001 | 101 |
