| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Elastofibroma in okinawa. A clinicopathologic study of 170 cases | Cancer | 1982 | 275 |
| 2 | Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor α production in trinitrobenzene sulphonic acid induced colitis | Gut | 1997 | 217 |
| 3 | Treatment and prognosis of thymic carcinoma | Cancer | 2002 | 177 |
| 4 | Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis | American Journal of Respiratory Cell and Molecular Biology | 2012 | 152 |
| 5 | Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets | Leukemia | 2018 | 146 |
| 6 | Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma | Blood | 2006 | 141 |
| 7 | Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients | International Journal of Radiation Oncology Biology Physics | 2004 | 136 |
| 8 | Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer | Breast Cancer Research and Treatment | 2016 | 128 |
| 9 | Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades | Genes Chromosomes and Cancer | 1998 | 117 |
| 10 | Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells | Journal of Cancer Research and Clinical Oncology | 2002 | 113 |
| 11 | Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway | Journal of Immunology | 2007 | 100 |
| 12 | Role of inflammatory infiltrates in triple negative breast cancer | Journal of Clinical Pathology | 2015 | 92 |
| 13 | A new type of hereditary motor and sensory neuropathy linked to chromosome 3 | Annals of Neurology | 1997 | 82 |
| 14 | Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial | EBioMedicine | 2017 | 80 |
| 15 | Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion | American Journal of Surgical Pathology | 2017 | 78 |
| 16 | Induction of Reactive Oxygen Species by Human T-Cell Leukemia Virus Type 1 Tax Correlates with DNA Damage and Expression of Cellular Senescence Marker | Journal of Virology | 2010 | 76 |
| 17 | Primary synovial sarcoma of the lung: report of two cases confirmed by molecular detection of SYT‐SSX fusion gene transcripts | Histopathology | 1999 | 73 |
| 18 | Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir | Blood | 2006 | 73 |
| 19 | ACE inhibitors and protection against pneumonia in elderly patients with stroke | Neurology | 2005 | 71 |
| 20 | Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats | Basic Research in Cardiology | 2010 | 69 |
| 21 | Exaggerated Blood Pressure Variability Superimposed on Hypertension Aggravates Cardiac Remodeling in Rats via Angiotensin II System-Mediated Chronic Inflammation | Hypertension | 2009 | 68 |
| 22 | Human papillomavirus DNA in squamous cell carcinoma of the lung. | Journal of Clinical Pathology | 1996 | 66 |
| 23 | Proposal of a new staging and grading system of the liver for primary biliary cirrhosis | Histopathology | 2006 | 65 |
| 24 | Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice | Oncogene | 2014 | 60 |
| 25 | Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation | European Journal of Pharmacology | 2006 | 58 |
| 26 | Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity | Cancer Science | 2004 | 57 |
| 27 | MicroRNA miR‐146a is induced by HTLV‐1 tax and increases the growth of HTLV‐1‐infected T‐cells | International Journal of Cancer | 2012 | 57 |
| 28 | Evaluation for clinical utility of GPC3, measured by a commercially available ELISA kit with Glypican‐3 (GPC3) antibody, as a serological and histological marker for hepatocellular carcinoma | Hepatology Research | 2010 | 55 |
| 29 | Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element | Blood | 2003 | 54 |
| 30 | Rhabdoid tumour of the lung is a dedifferentiated phenotype of pulmonary adenocarcinoma | Histopathology | 2000 | 50 |
| 31 | IL-18 Induces Airway Hyperresponsiveness and Pulmonary Inflammation via CD4+ T Cell and IL-13 | PLoS ONE | 2013 | 49 |
| 32 | Whole‐slide imaging at primary pathological diagnosis: Validation of whole‐slide imaging‐based primary pathological diagnosis at twelve Japanese academic institutes | Pathology International | 2017 | 47 |
| 33 | Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases | Brain Tumor Pathology | 2009 | 45 |
| 34 | Intraosseous growth of human prostate cancer in implanted adult human bone: Relationship of prostate cancer cells to osteoclasts in osteoblastic metastatic lesions | Prostate | 2004 | 42 |
| 35 | Interleukin-18 in Pulmonary Inflammatory Diseases | Journal of Interferon and Cytokine Research | 2012 | 42 |
| 36 | Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan | Journal of Clinical Pathology | 2000 | 41 |
| 37 | Potential Virulence Role of theLegionella pneumophila ptsPOrtholog | Infection and Immunity | 2001 | 40 |
| 38 | Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride | Cancer Science | 2004 | 40 |
| 39 | Lack of α2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction | Blood | 2002 | 39 |
| 40 | High serum levels of soluble interleukin-2 receptor (sIL2-R), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF) are associated with adverse clinical features and predict poor outcome in diffuse large B-cell lymphoma | Leukemia Research | 2017 | 39 |
| 41 | Accumulation of glycogen in sural nerve axons in adult-onset type III glycogenosis | Annals of Neurology | 1986 | 38 |
| 42 | Epstein–Barr virus (EBV)-related oral squamous cell carcinoma in Okinawa, a subtropical island, in southern Japan—simultaneously infected with human papillomavirus (HPV) | Oral Oncology | 2003 | 38 |
| 43 | Overexpression of Chitinase 3-Like 1/YKL-40 in Lung-Specific IL-18-Transgenic Mice, Smokers and COPD | PLoS ONE | 2011 | 37 |
| 44 | Interleukin-18 expression, CD8+ T cells, and eosinophils in lungs of nonsmokers with fatal asthma | Annals of Allergy, Asthma and Immunology | 2014 | 37 |
| 45 | Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan | BMC Cancer | 2015 | 37 |
| 46 | Comparative study of oral squamous cell carcinoma in Okinawa, Southern Japan and Sapporo in Hokkaido, Northern Japan; with special reference to human papillomavirus and Epstein-Barr virus infection | Journal of Oral Pathology and Medicine | 2000 | 36 |
| 47 | Extremely high Langerhans cell infiltration contributes to the favourable prognosis of HPV-infected squamous cell carcinoma and adenocarcinoma of the lung | Histopathology | 2001 | 36 |
| 48 | Primary Malignant Melanoma of the Esophagus Arising from a Melanotic Lesion: Report of a Case | Surgery Today | 2007 | 35 |
| 49 | Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus | Journal of Clinical Pathology | 2004 | 34 |
| 50 | Inhibitory effect of dietary monoglucosylceramide 1-O-beta-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats | Cancer Science | 2005 | 34 |
