| # | Title | Journal | Year | Citations |
|---|
| 1 | RAG-1-deficient mice have no mature B and T lymphocytes | Cell | 1992 | 2,652 |
| 2 | Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB | Nature | 1995 | 1,766 |
| 3 | Effects of an Rb mutation in the mouse | Nature | 1992 | 1,730 |
| 4 | Somatic activation of the K-ras oncogene causes early onset lung cancer in mice | Nature | 2001 | 1,060 |
| 5 | Skeletal and CNS Defects in Presenilin-1-Deficient Mice | Cell | 1997 | 937 |
| 6 | Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis | Science | 1994 | 843 |
| 7 | Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 | Nature Genetics | 1994 | 731 |
| 8 | Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene | Nature | 1997 | 717 |
| 9 | Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 | Cell | 1996 | 671 |
| 10 | ORIGINS ANDFUNCTIONS OFB-1 CELLS WITHNOTES ON THEROLE OFCD5 | Annual Review of Immunology | 2002 | 670 |
| 11 | Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice | Science | 1991 | 669 |
| 12 | Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis | Nature | 1996 | 668 |
| 13 | A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis | Cell | 1998 | 622 |
| 14 | A subset of p53-deficient embryos exhibit exencephaly | Nature Genetics | 1995 | 544 |
| 15 | Evidence for Cigarette Smoking as a Major Risk Factor for Periodontitis | Journal of Periodontology | 1993 | 513 |
| 16 | Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia | Journal of Biological Chemistry | 1997 | 501 |
| 17 | Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis | Journal of Biological Chemistry | 1998 | 458 |
| 18 | Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family | Cancer Cell | 2005 | 455 |
| 19 | Mouse Models of Tumor Development in Neurofibromatosis Type 1 | Science | 1999 | 441 |
| 20 | Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide | Journal of Biological Chemistry | 1998 | 385 |
| 21 | Cooperative tumorigenic effects of germline mutations in Rb and p53 | Nature Genetics | 1994 | 379 |
| 22 | Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects | Nature Genetics | 2000 | 379 |
| 23 | Comparative Studies of the Estrogen Receptors β and α and the Androgen Receptor in Normal Human Prostate Glands, Dysplasia, and in Primary and Metastatic Carcinoma | American Journal of Pathology | 2001 | 377 |
| 24 | Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses | Immunity | 2015 | 360 |
| 25 | Chronic Necrotizing Pulmonary Aspergillosis | Medicine (United States) | 1982 | 342 |
| 26 | Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy | Nature Genetics | 1996 | 337 |
| 27 | Intrinsic Requirement for Zinc Finger Transcription Factor Gfi-1 in Neutrophil Differentiation | Immunity | 2003 | 334 |
| 28 | Rescue of Cyclin D1 Deficiency by Knockin Cyclin E | Cell | 1999 | 331 |
| 29 | A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB | Cell | 1996 | 312 |
| 30 | Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus | Cell | 1982 | 301 |
| 31 | Immunologic effects of yogurt | American Journal of Clinical Nutrition | 2000 | 291 |
| 32 | The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries | Nature Genetics | 1998 | 275 |
| 33 | Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice | Nature Genetics | 1998 | 274 |
| 34 | Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis | Nature Genetics | 2000 | 268 |
| 35 | mTORC1 promotes survival through translational control of Mcl-1 | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 250 |
| 36 | Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment | Journal of Immunology | 2001 | 243 |
| 37 | Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain | Brain | 2009 | 243 |
| 38 | Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys | Science | 1985 | 217 |
| 39 | Cigarette Smoking in a Periodontal Practice | Journal of Periodontology | 1992 | 199 |
| 40 | Lectin histochemistry of mammalian endothelium | Histochemistry | 1987 | 197 |
| 41 | Homogeneous Sampling Accounts for the Increased Diagnostic Accuracy Using the ThinPrep™Processor | American Journal of Clinical Pathology | 1994 | 195 |
| 42 | Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells | Immunity | 1997 | 179 |
| 43 | E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability | Molecular Cell | 2000 | 174 |
| 44 | Mutational landscape of EGFR- , MYC- , and Kras- driven genetically engineered mouse models of lung adenocarcinoma | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 158 |
| 45 | Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention | Journal of Leukocyte Biology | 2008 | 154 |
| 46 | Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats | Environmental Health Perspectives | 2013 | 149 |
| 47 | Interferon-α-Induced Endogenous Superantigen | Immunity | 2001 | 133 |
| 48 | Androgen-supported estrogen-enhanced epithelial proliferation in the prostates of intact noble rats | Prostate | 1989 | 123 |
| 49 | Thrombospondin-1 Gene Expression Affects Survival and Tumor Spectrum of p53-Deficient Mice | American Journal of Pathology | 2001 | 122 |
| 50 | Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma | Genes and Development | 2016 | 122 |
