# | Title | Journal | Year | Citations |
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1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
2 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
4 | Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 | Cell Death and Differentiation | 2015 | 811 |
5 | Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes | Cell Death and Differentiation | 2009 | 599 |
6 | The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders | Annual Review of Physiology | 2016 | 490 |
7 | Nanostructured lipid carriers: Promising drug delivery systems for future clinics | Nanomedicine: Nanotechnology, Biology, and Medicine | 2016 | 488 |
8 | Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches | Brain Research Reviews | 2010 | 484 |
9 | Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758) | Aquatic Toxicology | 2018 | 471 |
10 | Towards the sustainable discovery and development of new antibiotics | Nature Reviews Chemistry | 2021 | 439 |
11 | Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation | Frontiers in Cellular Neuroscience | 2015 | 430 |
12 | Inhibition of the Human Thioredoxin System | Journal of Biological Chemistry | 2008 | 406 |
13 | Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size | FASEB Journal | 2002 | 351 |
14 | Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients | American Journal of Gastroenterology | 2004 | 345 |
15 | Bioconjugation with Maleimides: A Useful Tool for Chemical Biology | Chemistry - A European Journal | 2019 | 319 |
16 | Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases | Ageing Research Reviews | 2018 | 309 |
17 | miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease | Journal of Hepatology | 2013 | 300 |
18 | Bile acids: regulation of apoptosis by ursodeoxycholic acid | Journal of Lipid Research | 2009 | 286 |
19 | Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states | BMC Cancer | 2009 | 281 |
20 | Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 280 |
21 | Intestinal drug transporters: An overview | Advanced Drug Delivery Reviews | 2013 | 265 |
22 | Delivering the promise of miRNA cancer therapeutics | Drug Discovery Today | 2013 | 260 |
23 | Immune-mediated approaches against COVID-19 | Nature Nanotechnology | 2020 | 260 |
24 | Regulatory aspects on nanomedicines | Biochemical and Biophysical Research Communications | 2015 | 256 |
25 | Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria | Nature Cell Biology | 2003 | 245 |
26 | European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) | Redox Biology | 2017 | 242 |
27 | A systematic review of implementation frameworks of innovations in healthcare and resulting generic implementation framework | Health Research Policy and Systems | 2015 | 237 |
28 | Anti-inflammatory Effects of Phosphatidylcholine | Journal of Biological Chemistry | 2007 | 236 |
29 | Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System | Antioxidants and Redox Signaling | 2017 | 233 |
30 | Pyridinium salts: from synthesis to reactivity and applications | Organic Chemistry Frontiers | 2018 | 230 |
31 | Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans | Journal of Biological Chemistry | 2005 | 223 |
32 | Neurovascular Unit: a Focus on Pericytes | Molecular Neurobiology | 2012 | 220 |
33 | The role of p53 in apoptosis | Discovery Medicine | 2010 | 216 |
34 | Immune system targeting by biodegradable nanoparticles for cancer vaccines | Journal of Controlled Release | 2013 | 212 |
35 | Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease | Cell | 2019 | 209 |
36 | Synthesis of Chiral Cyclopentenones | Chemical Reviews | 2016 | 194 |
37 | Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation | Basic and Clinical Pharmacology and Toxicology | 2015 | 193 |
38 | Boronic acids as building blocks for the construction of therapeutically useful bioconjugates | Chemical Society Reviews | 2019 | 191 |
39 | Iminoboronates: A New Strategy for Reversible Protein Modification | Journal of the American Chemical Society | 2012 | 190 |
40 | The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art | International Journal of Molecular Sciences | 2019 | 186 |
41 | Diversity in bacterial lysis systems: bacteriophages show the way | FEMS Microbiology Reviews | 2013 | 185 |
42 | Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics | Advanced Healthcare Materials | 2021 | 182 |
43 | Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment | Environmental Research | 2015 | 181 |
44 | Polyphenols journey through blood-brain barrier towards neuronal protection | Scientific Reports | 2017 | 177 |
45 | MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells | FEBS Journal | 2009 | 175 |
46 | Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis | Clinical Science | 2015 | 175 |
47 | Chitosan Nanoparticles as a Mucoadhesive Drug Delivery System for Ocular Administration | Marine Drugs | 2017 | 175 |
48 | Synthetic organic chemistry driven by artificial intelligence | Nature Reviews Chemistry | 2019 | 173 |
49 | Molecular basis of bilirubin-induced neurotoxicity | Trends in Molecular Medicine | 2004 | 171 |
50 | miR-34a Regulates Mouse Neural Stem Cell Differentiation | PLoS ONE | 2011 | 170 |