| # | Title | Journal | Year | Citations |
|---|
| 1 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial | Lancet Oncology, The | 2010 | 3,794 |
| 2 | The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering | Journal of Endodontics | 2008 | 636 |
| 3 | A Proposed Model Linking Inflammation to Obesity, Diabetes, and Periodontal Infections | Journal of Periodontology | 2005 | 530 |
| 4 | Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1 | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 410 |
| 5 | PIK3CA Mutations and Copy Number Gains in Human Lung Cancers | Cancer Research | 2008 | 399 |
| 6 | Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery | Nature Nanotechnology | 2016 | 338 |
| 7 | The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA | Developmental Cell | 2010 | 333 |
| 8 | Multidrug efflux transporters in the MATE family | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2009 | 302 |
| 9 | Targeting LDH enzymes with a stiripentol analog to treat epilepsy | Science | 2015 | 302 |
| 10 | Tailoring the Oxygen Content of Graphite and Reduced Graphene Oxide for Specific Applications | Scientific Reports | 2016 | 266 |
| 11 | The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis | Arthritis Research and Therapy | 2006 | 259 |
| 12 | The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures | Journal of Biological Chemistry | 2009 | 254 |
| 13 | Structural basis for the drug extrusion mechanism by a MATE multidrug transporter | Nature | 2013 | 225 |
| 14 | Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression | Nature Neuroscience | 2019 | 217 |
| 15 | MECT1-MAML2 Fusion Transcript Defines a Favorable Subset of Mucoepidermoid Carcinoma | Clinical Cancer Research | 2006 | 209 |
| 16 | Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells | PLoS ONE | 2009 | 205 |
| 17 | In vitro characterization of human dental pulp cells: various isolation methods and culturing environments | Cell and Tissue Research | 2006 | 195 |
| 18 | Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity | Food and Chemical Toxicology | 2010 | 191 |
| 19 | Genome-Wide Screening of Genes Required for Swarming Motility in Escherichia coli K-12 | Journal of Bacteriology | 2007 | 181 |
| 20 | Determination of polycyclic aromatic hydrocarbons in food samples by automated on-line in-tube solid-phase microextraction coupled with high-performance liquid chromatography-fluorescence detection | Journal of Chromatography A | 2010 | 177 |
| 21 | Treatment of severe anterior open bite with skeletal anchorage in adults: Comparison with orthognathic surgery outcomes | American Journal of Orthodontics and Dentofacial Orthopedics | 2007 | 175 |
| 22 | S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells | Nature Communications | 2014 | 175 |
| 23 | The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally? | Cellular and Molecular Immunology | 2018 | 174 |
| 24 | High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD) | Circulation | 2018 | 174 |
| 25 | Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants | Indoor Air | 2014 | 173 |
| 26 | Relationships between craniofacial pain and bruxism* | Journal of Oral Rehabilitation | 2008 | 163 |
| 27 | Brain Cannabinoid CB2 Receptor in Schizophrenia | Biological Psychiatry | 2010 | 163 |
| 28 | Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE) | Biological and Pharmaceutical Bulletin | 2007 | 161 |
| 29 | C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2008 | 161 |
| 30 | Effectiveness and stability of silane coupling agent incorporated in ‘universal’ adhesives | Dental Materials | 2016 | 156 |
| 31 | Emerging trends in the etiology of enteric pathogens as evidenced from an active surveillance of hospitalized diarrhoeal patients in Kolkata, India | Gut Pathogens | 2010 | 154 |
| 32 | Clinicopathological significance of the CRTC3–MAML2 fusion transcript in mucoepidermoid carcinoma | Modern Pathology | 2009 | 153 |
| 33 | Genome-Wide Association Study of Schizophrenia in a Japanese Population | Biological Psychiatry | 2011 | 152 |
| 34 | Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: A population-based cohort study | Preventive Medicine | 2009 | 151 |
| 35 | On–off system for PI3-kinase–Akt signaling through S -nitrosylation of phosphatase with sequence homology to tensin (PTEN) | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 150 |
| 36 | Systemically Injectable Enzyme‐Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors | Angewandte Chemie - International Edition | 2016 | 149 |
| 37 | Synthesis and modification of apatite nanoparticles for use in dental and medical applications | Japanese Dental Science Review | 2015 | 147 |
| 38 | Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes | Molecular Cell | 2016 | 144 |
| 39 | Determination of aflatoxins in food samples by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography–mass spectrometry | Journal of Chromatography A | 2009 | 135 |
| 40 | A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment | Scientific Reports | 2017 | 133 |
| 41 | Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer | Cancer Discovery | 2016 | 132 |
| 42 | MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors | International Journal of Cancer | 2009 | 131 |
| 43 | Chemokines in homeostasis and diseases | Cellular and Molecular Immunology | 2018 | 126 |
| 44 | Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion | International Journal of Molecular Sciences | 2019 | 124 |
| 45 | Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation | Chemosphere | 2008 | 120 |
| 46 | Calcium response in single osteocytes to locally applied mechanical stimulus: Differences in cell process and cell body | Journal of Biomechanics | 2009 | 120 |
| 47 | A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 120 |
| 48 | Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 117 |
| 49 | FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non‐Hodgkin lymphoma | British Journal of Haematology | 2009 | 117 |
| 50 | Hereditary Lung Cancer Syndrome Targets Never Smokers with Germline EGFR Gene T790M Mutations | Journal of Thoracic Oncology | 2014 | 112 |
