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Top Articles

#TitleJournalYearCitations
1The Hallmarks of CancerCell200024,832
2Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell200510,880
3Integrins: Versatility, modulation, and signaling in cell adhesionCell19929,858
4MicroRNA expression profiles classify human cancersNature20058,931
5IntegrinsCell20027,714
6Most mammalian mRNAs are conserved targets of microRNAsGenome Research20097,226
7Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature19936,331
8Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR ComplexScience20055,761
9Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsNature Genetics20035,434
10The Structure of Haplotype Blocks in the Human GenomeScience20025,300
11A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASEJournal of Biological Chemistry19525,298
12Prediction of Mammalian MicroRNA TargetsCell20034,682
13Macrophage Activation and Polarization: Nomenclature and Experimental GuidelinesImmunity20144,638
14Alternative isoform regulation in human tissue transcriptomesNature20084,508
15Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsNature20054,435
16The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansNature20004,315
17The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray)Science20063,945
18Histone H3K27ac separates active from poised enhancers and predicts developmental stateProceedings of the National Academy of Sciences of the United States of America20103,446
19Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseNature20003,142
20An Essential Role for NF-κB in Preventing TNF-α-Induced Cell DeathScience19963,073
21An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansScience20013,041
22p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsCell19932,848
23p53 is required for radiation-induced apoptosis in mouse thymocytesNature19932,829
24In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like stateNature20072,517
25Tumour invasion and metastasis initiated by microRNA-10b in breast cancerNature20072,382
26Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the CytoskeletonCurrent Biology20042,370
27Polycomb complexes repress developmental regulators in murine embryonic stem cellsNature20062,273
28I kappa B: a specific inhibitor of the NF-kappa B transcription factorScience19882,240
29In vivo genome editing using Staphylococcus aureus Cas9Nature20152,237
30Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursNature19962,223
31An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumorsNature Genetics20082,218
32Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput ScreeningCell20092,200
33Nanoparticles in Medicine: Therapeutic Applications and DevelopmentsClinical Pharmacology and Therapeutics20082,156
34Creation of human tumour cells with defined genetic elementsNature19992,148
35Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein ReceptorScience19962,127
36Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour VirusesNature19702,104
37Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature19792,099
38Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNAMolecular Cell20042,097
39Prediction of Plant MicroRNA TargetsCell20022,088
40Epigenetic memory in induced pluripotent stem cellsNature20102,011
41Role for DNA methylation in genomic imprintingNature19932,001
42The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsGenes and Development19991,951
43Mechanisms and Functions of Cell DeathAnnual Review of Cell Biology19911,941
44The Genetic Landscape of a CellScience20101,937
45Tumor spectrum analysis in p53-mutant miceCurrent Biology19941,903
46The male-specific region of the human Y chromosome is a mosaic of discrete sequence classesNature20031,887
47In vivo half-life of a protein is a function of its amino-terminal residueScience19861,870
48HIF-1α Is Essential for Myeloid Cell-Mediated InflammationCell20031,862
49WT-1 is required for early kidney developmentCell19931,853
50Deep learning with coherent nanophotonic circuitsNature Photonics20171,845