| # | Title | Journal | Year | Citations |
|---|
| 1 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 2 | Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets | Cell | 2005 | 10,880 |
| 3 | Integrins: Versatility, modulation, and signaling in cell adhesion | Cell | 1992 | 9,858 |
| 4 | MicroRNA expression profiles classify human cancers | Nature | 2005 | 8,931 |
| 5 | Integrins | Cell | 2002 | 7,714 |
| 6 | Most mammalian mRNAs are conserved targets of microRNAs | Genome Research | 2009 | 7,226 |
| 7 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 6,331 |
| 8 | Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex | Science | 2005 | 5,761 |
| 9 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals | Nature Genetics | 2003 | 5,434 |
| 10 | The Structure of Haplotype Blocks in the Human Genome | Science | 2002 | 5,300 |
| 11 | A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE | Journal of Biological Chemistry | 1952 | 5,298 |
| 12 | Prediction of Mammalian MicroRNA Targets | Cell | 2003 | 4,682 |
| 13 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 14 | Alternative isoform regulation in human tissue transcriptomes | Nature | 2008 | 4,508 |
| 15 | Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs | Nature | 2005 | 4,435 |
| 16 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans | Nature | 2000 | 4,315 |
| 17 | The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray) | Science | 2006 | 3,945 |
| 18 | Histone H3K27ac separates active from poised enhancers and predicts developmental state | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 3,446 |
| 19 | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase | Nature | 2000 | 3,142 |
| 20 | An Essential Role for NF-kappa B in Preventing TNF-alpha -Induced Cell Death | Science | 1996 | 3,073 |
| 21 | An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans | Science | 2001 | 3,041 |
| 22 | p53-dependent apoptosis modulates the cytotoxicity of anticancer agents | Cell | 1993 | 2,848 |
| 23 | p53 is required for radiation-induced apoptosis in mouse thymocytes | Nature | 1993 | 2,829 |
| 24 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state | Nature | 2007 | 2,517 |
| 25 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | Nature | 2007 | 2,382 |
| 26 | Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton | Current Biology | 2004 | 2,370 |
| 27 | Polycomb complexes repress developmental regulators in murine embryonic stem cells | Nature | 2006 | 2,273 |
| 28 | I kappa B: a specific inhibitor of the NF-kappa B transcription factor | Science | 1988 | 2,240 |
| 29 | In vivo genome editing using Staphylococcus aureus Cas9 | Nature | 2015 | 2,237 |
| 30 | Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours | Nature | 1996 | 2,223 |
| 31 | An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors | Nature Genetics | 2008 | 2,218 |
| 32 | Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening | Cell | 2009 | 2,200 |
| 33 | Nanoparticles in Medicine: Therapeutic Applications and Developments | Clinical Pharmacology and Therapeutics | 2008 | 2,156 |
| 34 | Creation of human tumour cells with defined genetic elements | Nature | 1999 | 2,148 |
| 35 | Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor | Science | 1996 | 2,127 |
| 36 | Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses | Nature | 1970 | 2,104 |
| 37 | Molecular structure of a left-handed double helical DNA fragment at atomic resolution | Nature | 1979 | 2,099 |
| 38 | Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA | Molecular Cell | 2004 | 2,097 |
| 39 | Prediction of Plant MicroRNA Targets | Cell | 2002 | 2,088 |
| 40 | Epigenetic memory in induced pluripotent stem cells | Nature | 2010 | 2,011 |
| 41 | Role for DNA methylation in genomic imprinting | Nature | 1993 | 2,001 |
| 42 | The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms | Genes and Development | 1999 | 1,951 |
| 43 | Mechanisms and Functions of Cell Death | Annual Review of Cell Biology | 1991 | 1,941 |
| 44 | The Genetic Landscape of a Cell | Science | 2010 | 1,937 |
| 45 | Tumor spectrum analysis in p53-mutant mice | Current Biology | 1994 | 1,903 |
| 46 | The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes | Nature | 2003 | 1,887 |
| 47 | In vivo half-life of a protein is a function of its amino-terminal residue | Science | 1986 | 1,870 |
| 48 | HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation | Cell | 2003 | 1,862 |
| 49 | WT-1 is required for early kidney development | Cell | 1993 | 1,853 |
| 50 | Deep learning with coherent nanophotonic circuits | Nature Photonics | 2017 | 1,845 |
