| # | Title | Journal | Year | Citations |
|---|
| 1 | Expansion of the eukaryotic proteome by alternative splicing | Nature | 2010 | 1,787 |
| 2 | C-reactive Protein | Journal of Biological Chemistry | 2004 | 1,202 |
| 3 | Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia | Nature Reviews Drug Discovery | 2004 | 1,044 |
| 4 | Oxidative damage in Alzheimer's | Nature | 1996 | 903 |
| 5 | Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors | Neuron | 2009 | 809 |
| 6 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin | Nature Chemical Biology | 2010 | 757 |
| 7 | H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | Neuropsychopharmacology | 2003 | 694 |
| 8 | Mechanism and regulation of eukaryotic protein synthesis | Microbiological Reviews | 1992 | 609 |
| 9 | Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores: Raman Microscopic Evidence† | Biochemistry | 2003 | 543 |
| 10 | MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F | Science | 2007 | 458 |
| 11 | The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation | Molecular and Cellular Biology | 2003 | 446 |
| 12 | The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro | Cell | 1990 | 442 |
| 13 | Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein | Journal of the American Chemical Society | 2004 | 421 |
| 14 | Pyruvate Carboxylase | Journal of Biological Chemistry | 1963 | 407 |
| 15 | Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences | Proteins: Structure, Function and Bioinformatics | 1994 | 379 |
| 16 | Crystal structure of a retroviral protease proves relationship to aspartic protease family | Nature | 1989 | 378 |
| 17 | The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration | Journal of Virology | 1989 | 372 |
| 18 | How insulin engages its primary binding site on the insulin receptor | Nature | 2013 | 364 |
| 19 | Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms | Cancer Cell | 2015 | 341 |
| 20 | Pyruvate Carboxylase | Journal of Biological Chemistry | 1963 | 305 |
| 21 | Crystal structure of deoxygenated limulus polyphemus subunit II hemocyanin at 2.18 Å resolution: Clues for a mechanism for allosteric regulation | Protein Science | 1993 | 301 |
| 22 | Eukaryotic protein elongation factors | Trends in Biochemical Sciences | 1990 | 291 |
| 23 | Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II) | Biochemical Journal | 1975 | 281 |
| 24 | mRNA helicases: the tacticians of translational control | Nature Reviews Molecular Cell Biology | 2011 | 279 |
| 25 | DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination | Science Signaling | 2010 | 278 |
| 26 | Biochemical and Kinetic Characterization of the RNA Helicase Activity of Eukaryotic Initiation Factor 4A | Journal of Biological Chemistry | 1999 | 273 |
| 27 | RNA Polymerase-Promoter Interactions: the Comings and Goings of RNA Polymerase | Journal of Bacteriology | 1998 | 268 |
| 28 | 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro | Molecular Pharmacology | 2003 | 263 |
| 29 | Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron | Journal of Biological Chemistry | 2005 | 261 |
| 30 | STAT3 Participates in Transcriptional Activation of the C-reactive Protein Gene by Interleukin-6 | Journal of Biological Chemistry | 1996 | 251 |
| 31 | Secondary Structure of α-Synuclein Oligomers: Characterization by Raman and Atomic Force Microscopy | Journal of Molecular Biology | 2006 | 248 |
| 32 | Molecular Biology of Serotonin Receptors - Structure and Function at the Molecular Level | Current Topics in Medicinal Chemistry | 2002 | 243 |
| 33 | Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo | Psychopharmacology | 2009 | 240 |
| 34 | Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress | Molecular and Cellular Biology | 2014 | 236 |
| 35 | ISOLATION AND PROPERTIES OF INTACT MITOCHONDRIA FROM SPHEROPLASTS OF YEAST | Journal of Bacteriology | 1964 | 236 |
| 36 | Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine | Journal of Histochemistry and Cytochemistry | 1998 | 234 |
| 37 | Protein Synthesis Initiation in Eukaryotic Cells | Cold Spring Harbor Perspectives in Biology | 2018 | 230 |
| 38 | Biological Aspects of Inorganic Polyphosphates | Annual Review of Biochemistry | 1988 | 225 |
| 39 | The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). | Molecular and Cellular Biology | 1990 | 224 |
| 40 | eIF4A: The godfather of the DEAD box helicases | Progress in Molecular Biology and Translational Science | 2002 | 224 |
| 41 | Inhibition of Eukaryotic Translation Initiation by the Marine Natural Product Pateamine A | Molecular Cell | 2005 | 220 |
| 42 | Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding | Science | 2004 | 218 |
| 43 | Cap-dependent and cap-independent translation in eukaryotic systems | Gene | 2004 | 218 |
| 44 | Specificity and nonspecificity in RNA–protein interactions | Nature Reviews Molecular Cell Biology | 2015 | 216 |
| 45 | Mechanism for Nucleocytoplasmic Shuttling of Histone Deacetylase 7 | Journal of Biological Chemistry | 2001 | 208 |
| 46 | Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia | Journal of Biological Chemistry | 2005 | 208 |
| 47 | Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 201 |
| 48 | Negative regulation of the interferon response by an interferon-induced long non-coding RNA | Nucleic Acids Research | 2014 | 199 |
| 49 | PURIFICATION AND PROPERTIES OF ENZYMES INVOLVED IN THE PROPIONIC ACID FERMENTATION | Journal of Bacteriology | 1964 | 197 |
| 50 | Abnormal Development of Forebrain Midline Glia and Commissural Projections inNfiaKnock-Out Mice | Journal of Neuroscience | 2003 | 196 |
