| # | Title | Journal | Year | Citations |
|---|
| 1 | Foreign body reaction to biomaterials | Seminars in Immunology | 2008 | 3,942 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Nature Medicine | 1996 | 2,545 |
| 4 | Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin | Cell Host and Microbe | 2013 | 1,699 |
| 5 | Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes | Nature | 1993 | 1,125 |
| 6 | Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease | Journal of Neuroscience | 2009 | 1,003 |
| 7 | Oxidative stress and mitochondrial dysfunction in Alzheimer's disease | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2014 | 982 |
| 8 | Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer | Nature Genetics | 2004 | 976 |
| 9 | THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME | Journal of Experimental Medicine | 1956 | 954 |
| 10 | Segmental Duplications and Copy-Number Variation in the Human Genome | American Journal of Human Genetics | 2005 | 872 |
| 11 | Normalizing the environment recapitulates adult human immune traits in laboratory mice | Nature | 2016 | 848 |
| 12 | Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity | Science | 1996 | 845 |
| 13 | Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 734 |
| 14 | Induction of TH1 and TH2 Immunity in Neonatal Mice | Science | 1996 | 661 |
| 15 | Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2010 | 587 |
| 16 | Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons | American Journal of Pathology | 1999 | 570 |
| 17 | Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease | Free Radical Biology and Medicine | 2013 | 565 |
| 18 | Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances | Molecular Neurodegeneration | 2020 | 562 |
| 19 | Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells | Immunity | 2008 | 533 |
| 20 | Inflammatory Response to Implants | ASAIO Journal | 1988 | 516 |
| 21 | The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease | Nature Immunology | 2007 | 507 |
| 22 | Involvement of Oxidative Stress in Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2006 | 484 |
| 23 | Crystal structure of the human prion protein reveals a mechanism for oligomerization | Nature Structural Biology | 2001 | 474 |
| 24 | Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite | Science | 1980 | 471 |
| 25 | A new human prostate carcinoma cell line, 22Rv1 | In Vitro Cellular and Developmental Biology - Animal | 1999 | 463 |
| 26 | A role for leukocyte-endothelial adhesion mechanisms in epilepsy | Nature Medicine | 2008 | 453 |
| 27 | Oxidative stress in Alzheimer disease: A possibility for prevention | Neuropharmacology | 2010 | 431 |
| 28 | Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease | Journal of Neurochemistry | 2012 | 422 |
| 29 | THE EXISTENCE OF TWO FORMS OF HYPERTENSIN | Journal of Experimental Medicine | 1954 | 417 |
| 30 | Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas | Cancer Cell | 2018 | 396 |
| 31 | Overview of the 2022 WHO Classification of Thyroid Neoplasms | Endocrine Pathology | 2022 | 388 |
| 32 | Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 373 |
| 33 | Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2 | Nature Immunology | 2014 | 373 |
| 34 | The Polymeric Immunoglobulin Receptor Translocates Pneumococci across Human Nasopharyngeal Epithelial Cells | Cell | 2000 | 365 |
| 35 | First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip | Science Translational Medicine | 2012 | 360 |
| 36 | Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment | Journal of Alzheimer's Disease | 2010 | 357 |
| 37 | LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1 | Human Molecular Genetics | 2012 | 356 |
| 38 | Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors | Nature Reviews Microbiology | 2010 | 349 |
| 39 | In vitro and in vivo interactions of cells with biomaterials | Biomaterials | 1988 | 331 |
| 40 | Evidence that A?42 is the real culprit in alzheimer's disease | Annals of Neurology | 1995 | 330 |
| 41 | Sporadic human prion diseases: molecular insights and diagnosis | Lancet Neurology, The | 2012 | 319 |
| 42 | Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans | Scientific Reports | 2016 | 319 |
| 43 | Causes of oxidative stress in Alzheimer disease | Cellular and Molecular Life Sciences | 2007 | 312 |
| 44 | THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE | Journal of Experimental Medicine | 1957 | 310 |
| 45 | Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients | American Journal of Pathology | 2008 | 308 |
| 46 | Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer | Science | 2012 | 304 |
| 47 | The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity | Nature Medicine | 2016 | 299 |
| 48 | IL-1 family nomenclature | Nature Immunology | 2010 | 294 |
| 49 | Foreign-body giant cells and polyurethane biostability:In vivo correlation of cell adhesion and surface cracking | Journal of Biomedical Materials Research Part B | 1991 | 293 |
| 50 | Acceleration of Amyloid Fibril Formation by Specific Binding of Aβ-(1–40) Peptide to Ganglioside-containing Membrane Vesicles | Journal of Biological Chemistry | 1997 | 291 |
