| # | Title | Journal | Year | Citations |
|---|
| 1 | A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants | Nature Genetics | 2016 | 1,167 |
| 2 | A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETECTION AND DETERMINATION OF KETO SUGARS AND TRIOSES | Journal of Biological Chemistry | 1951 | 1,035 |
| 3 | Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration | Nature Genetics | 2006 | 1,001 |
| 4 | RPE lipofuscin and its role in retinal pathobiology | Experimental Eye Research | 2005 | 560 |
| 5 | The Retinal Pigment Epithelium in Health and Disease | Current Molecular Medicine | 2010 | 502 |
| 6 | A fast algorithm to determine fractal dimensions by box counting | Physics Letters, Section A: General, Atomic and Solid State Physics | 1989 | 414 |
| 7 | The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells | Investigative Ophthalmology and Visual Science | 2000 | 410 |
| 8 | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene ( LIPC ) | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 406 |
| 9 | A SPECTROPHOTOMETRIC METHOD FOR THE MICRODETERMINATION OF HEXOSAMINES | Journal of Biological Chemistry | 1950 | 342 |
| 10 | The bisretinoids of retinal pigment epithelium | Progress in Retinal and Eye Research | 2012 | 329 |
| 11 | Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 324 |
| 12 | Diagnostic guidelines in central nervous system Whipple's disease | Annals of Neurology | 1996 | 314 |
| 13 | Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy | Nature Medicine | 1996 | 303 |
| 14 | The susceptibility of the retina to photochemical damage from visible light | Progress in Retinal and Eye Research | 2012 | 294 |
| 15 | Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization | Graefe's Archive for Clinical and Experimental Ophthalmology | 1994 | 293 |
| 16 | A2E, a byproduct of the visual cycle | Vision Research | 2003 | 262 |
| 17 | A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture | Investigative Ophthalmology and Visual Science | 1999 | 242 |
| 18 | IMI – Report on Experimental Models of Emmetropization and Myopia | | 2019 | 241 |
| 19 | A Partial Intensity Invariant Feature Descriptor for Multimodal Retinal Image Registration | IEEE Transactions on Biomedical Engineering | 2010 | 240 |
| 20 | Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma | Progress in Retinal and Eye Research | 2003 | 236 |
| 21 | The Biosynthesis of A2E, a Fluorophore of Aging Retina, Involves the Formation of the Precursor, A2-PE, in the Photoreceptor Outer Segment Membrane | Journal of Biological Chemistry | 2000 | 227 |
| 22 | Retinal Degeneration in Mice Lacking the gamma Subunit of the Rod cGMP Phosphodiesterase | Science | 1996 | 226 |
| 23 | Historical review: the field of protein methylation | Trends in Biochemical Sciences | 2007 | 221 |
| 24 | Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE | Investigative Ophthalmology and Visual Science | 2002 | 221 |
| 25 | Extended haplotypes in the complement factor H (CFH) and CFH‐related (CFHR) family of genes protect against age‐related macular degeneration: Characterization, ethnic distribution and evolutionary implications | Annals of Medicine | 2006 | 217 |
| 26 | Genotyping microarray (gene chip) for theABCR(ABCA4) gene | Human Mutation | 2003 | 214 |
| 27 | Transplantation of RPE in age-related macular degeneration: Observations in disciform lesions and dry RPE atrophy | Graefe's Archive for Clinical and Experimental Ophthalmology | 1997 | 212 |
| 28 | PHOTOPHYSICAL STUDIES ON HUMAN RETINAL LIPOFUSCIN | Photochemistry and Photobiology | 1995 | 206 |
| 29 | Review: Oxidative Stress and Disease | Journal of Ocular Pharmacology and Therapeutics | 2000 | 205 |
| 30 | Long-Term Outcome of RPE Allografts in Non-Immunosuppressed Patients with AMD | European Journal of Ophthalmology | 1999 | 202 |
| 31 | Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy | Gene Therapy | 2008 | 202 |
| 32 | SOD2 Knockdown Mouse Model of Early AMD | | 2007 | 201 |
| 33 | Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells | Free Radical Biology and Medicine | 2012 | 196 |
| 34 | Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2 | Investigative Ophthalmology and Visual Science | 2001 | 195 |
| 35 | The RAGE Axis in Early Diabetic Retinopathy | | 2005 | 189 |
| 36 | LXII Edward Jackson Lecture: Open Angle Glaucoma After Vitrectomy | American Journal of Ophthalmology | 2006 | 185 |
| 37 | Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia | Nature Genetics | 2015 | 183 |
| 38 | Fractal analysis of a voltage-dependent potassium channel from cultured mouse hippocampal neurons | Biophysical Journal | 1987 | 179 |
| 39 | Identification of tryptophan oxidation products in bovine α‐crystallin | Protein Science | 1998 | 177 |
| 40 | Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations | Progress in Retinal and Eye Research | 2020 | 173 |
| 41 | Reticular Macular Disease | American Journal of Ophthalmology | 2009 | 169 |
| 42 | Species differences in the responses of the eye to irritation and trauma: a hypothesis of divergence in ocular defense mechanisms, and the choice of experimental animals for eye research | Experimental Eye Research | 1984 | 167 |
| 43 | Phospholipid meets all-trans-retinal: the making of RPE bisretinoids | Journal of Lipid Research | 2010 | 165 |
| 44 | α-Crystallin. The isolation and characterization of distinct macromolecular fractions | Biochemical Journal | 1971 | 162 |
| 45 | Quantitative Fundus Autofluorescence in Recessive Stargardt Disease | | 2014 | 160 |
| 46 | Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro | Journal of Cataract and Refractive Surgery | 2004 | 156 |
| 47 | The effect of H2O2 upon thioredoxin-enriched lens epithelial cells | Journal of Biological Chemistry | 1988 | 156 |
| 48 | Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin | Experimental Eye Research | 2006 | 155 |
| 49 | Postsurgical hypotony: relationship to fistulization, inflammation, chorioretinal lesions, and the vitreous | Survey of Ophthalmology | 1996 | 154 |
| 50 | Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography | Ophthalmology | 2006 | 154 |
