| # | Title | Journal | Year | Citations |
|---|
| 1 | The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease | Science | 2006 | 4,472 |
| 2 | Disease-Specific Induced Pluripotent Stem Cells | Cell | 2008 | 2,071 |
| 3 | Innate immunity of the newborn: basic mechanisms and clinical correlates | Nature Reviews Immunology | 2007 | 1,041 |
| 4 | Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells | Nature Biotechnology | 2009 | 985 |
| 5 | Rates of medication errors among depressed and burnt out residents: prospective cohort study | BMJ: British Medical Journal | 2008 | 945 |
| 6 | Halothane–Morphine Compared with High-Dose Sufentanil for Anesthesia and Postoperative Analgesia in Neonatal Cardiac Surgery | New England Journal of Medicine | 1992 | 866 |
| 7 | Generation of induced pluripotent stem cells from human blood | Blood | 2009 | 559 |
| 8 | Effects of Decreasing Sugar-Sweetened Beverage Consumption on Body Weight in Adolescents: A Randomized, Controlled Pilot Study | Pediatrics | 2006 | 475 |
| 9 | Practice parameter for the diagnosis and management of primary immunodeficiency | Annals of Allergy, Asthma and Immunology | 2005 | 452 |
| 10 | A Reduced–Glycemic Load Diet in the Treatment of Adolescent Obesity | JAMA Pediatrics | 2003 | 383 |
| 11 | Maternal Fish Intake during Pregnancy, Blood Mercury Levels, and Child Cognition at Age 3 Years in a US Cohort | American Journal of Epidemiology | 2008 | 369 |
| 12 | Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes | Nature Genetics | 2011 | 356 |
| 13 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
| 14 | Effects of a Low–Glycemic Load vs Low-Fat Diet in Obese Young Adults | JAMA - Journal of the American Medical Association | 2007 | 314 |
| 15 | Podocyte-Specific Loss of Functional MicroRNAs Leads to Rapid Glomerular and Tubular Injury | Journal of the American Society of Nephrology: JASN | 2008 | 277 |
| 16 | Weight Status in Childhood as a Predictor of Becoming Overweight or Hypertensive in Early Adulthood** | Obesity | 2005 | 274 |
| 17 | Adherence challenges in the management of type 1 diabetes in adolescents: prevention and intervention | Current Opinion in Pediatrics | 2010 | 269 |
| 18 | Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D? | Pediatrics | 2009 | 268 |
| 19 | Mutations in PNKP cause microcephaly, seizures and defects in DNA repair | Nature Genetics | 2010 | 268 |
| 20 | Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development | Nature Genetics | 2005 | 267 |
| 21 | Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture | Nature Genetics | 2010 | 259 |
| 22 | Emerging Cerebral Connectivity in the Human Fetal Brain: An MR Tractography Study | Cerebral Cortex | 2012 | 245 |
| 23 | I-PASS, a Mnemonic to Standardize Verbal Handoffs | Pediatrics | 2012 | 235 |
| 24 | Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial | European Heart Journal | 2009 | 226 |
| 25 | The protective effects of good parenting on adolescents | Current Opinion in Pediatrics | 2005 | 224 |
| 26 | ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome | Nature Structural and Molecular Biology | 2011 | 218 |
| 27 | Bisphenol A and Related Compounds in Dental Materials | Pediatrics | 2010 | 210 |
| 28 | GPR56 Regulates Pial Basement Membrane Integrity and Cortical Lamination | Journal of Neuroscience | 2008 | 209 |
| 29 | Looking Beyond Where Children Die: Determinants and Effects of Planning a Child's Location of Death | Journal of Pain and Symptom Management | 2009 | 200 |
| 30 | Structural brain alterations associated with dyslexia predate reading onset | NeuroImage | 2011 | 200 |
| 31 | Functional characteristics of developmental dyslexia in left-hemispheric posterior brain regions predate reading onset | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 200 |
| 32 | Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides | Infection and Immunity | 2005 | 197 |
| 33 | Expanded Newborn Screening for Biochemical Disorders: The Effect of a False-Positive Result | Pediatrics | 2006 | 196 |
| 34 | Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States | American Journal of Obstetrics and Gynecology | 2010 | 196 |
| 35 | Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adults | American Journal of Clinical Nutrition | 2005 | 189 |
| 36 | Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic β Cell Growth and Function | Journal of Biological Chemistry | 2006 | 189 |
| 37 | Effects of the Accreditation Council for Graduate Medical Education Duty Hour Limits on Sleep, Work Hours, and Safety | Pediatrics | 2008 | 175 |
| 38 | Pediatric Concussions in United States Emergency Departments in the Years 2002 to 2006 | Journal of Pediatrics | 2010 | 175 |
| 39 | Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease | Gastroenterology | 2014 | 175 |
| 40 | Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers | Cancer Cell | 2006 | 172 |
| 41 | DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation | Molecular Cell | 2011 | 166 |
| 42 | Whole-Exome Sequencing and Homozygosity Analysis Implicate Depolarization-Regulated Neuronal Genes in Autism | PLoS Genetics | 2012 | 164 |
| 43 | Infliximab for Intravenous Immunoglobulin Resistance in Kawasaki Disease: A Retrospective Study | Journal of Pediatrics | 2011 | 162 |
| 44 | A Functional Element Necessary for Fetal Hemoglobin Silencing | New England Journal of Medicine | 2011 | 161 |
| 45 | Birth Before 39 Weeks' Gestation Is Associated With Worse Outcomes in Neonates With Heart Disease | Pediatrics | 2010 | 160 |
| 46 | Pediatric KIT–Wild-Type and Platelet-Derived Growth Factor Receptor α–Wild-Type Gastrointestinal Stromal Tumors Share KIT Activation but not Mechanisms of Genetic Progression with Adult Gastrointestinal Stromal Tumors | Cancer Research | 2007 | 159 |
| 47 | Perceived discrimination and mental health symptoms among Black men with HIV. | Cultural Diversity and Ethnic Minority Psychology | 2011 | 159 |
| 48 | Increasing Recovery Time Between Injuries Improves Cognitive Outcome After Repetitive Mild Concussive Brain Injuries in Mice | Neurosurgery | 2012 | 159 |
| 49 | Large-Scale Validation of the Centor and McIsaac Scores to Predict Group A Streptococcal Pharyngitis | Archives of Internal Medicine | 2012 | 149 |
| 50 | A Randomized Clinical Trial of the Management of Esophageal Coins in Children | Pediatrics | 2005 | 144 |
