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Physiology and Therapeutics
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top-articles
Physiology and Therapeutics
125
(top 1%)
papers
6.2K
(top 1%)
citations
45
(top 1%)
h
-index
76
(top 1%)
g
-index
129
all documents
6.4K
doc citations
1.4K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
Annals of Neurology
2006
517
2
Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis
Neurobiology of Disease
2013
260
3
Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein
Molecular and Cellular Biology
2005
233
4
Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation
Progress in Neurobiology
2007
232
5
Oxidative stress and stress signaling: menace of diabetic cardiomyopathy
Acta Pharmacologica Sinica
2005
171
6
Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1
British Journal of Pharmacology
2005
167
7
Peroxynitrite and Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease
Antioxidants and Redox Signaling
2003
155
8
Caffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum
Journal of Neurochemistry
2008
155
9
Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
Neuroscience Letters
2008
146
10
Overexpression of Metallothionein in Pancreatic -Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes
Diabetes
2001
136
11
Deposition of iron and ?-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets
Journal of Neurochemistry
2006
127
12
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
Journal of Neuroinflammation
2008
117
13
Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats
Journal of Molecular and Cellular Cardiology
2005
110
14
Caffeine Protects Against Disruptions of the Blood-Brain Barrier in Animal Models of Alzheimer's and Parkinson's Diseases
Journal of Alzheimer's Disease
2010
106
15
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
Biochimica Et Biophysica Acta - Molecular Basis of Disease
2014
103
16
Brain neutral lipids mass is increased in α-synuclein gene-ablated mice
Journal of Neurochemistry
2006
99
17
α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding
Biochemistry
2005
94
18
Fatty acid incorporation is decreased in astrocytes cultured from α-synuclein gene-ablated mice
Journal of Neurochemistry
2005
90
19
Brain Arachidonic Acid Incorporation Is Decreased in Heart Fatty Acid Binding Protein Gene-Ablated Mice
Biochemistry
2005
86
20
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease
Journal of Neuroinflammation
2012
84
21
Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
Mechanisms of Ageing and Development
2006
81
22
Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism
Biochemical and Biophysical Research Communications
2004
77
23
Hormonal regulation of longevity in mammals
Ageing Research Reviews
2007
76
24
An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction
Journal of Lipid Research
2008
76
25
LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes
Journal of Lipid Research
2011
73
26
Altered methionine metabolism in long living Ames dwarf mice
Experimental Gerontology
2003
71
27
Placental Insufficiency Leads to Developmental Hypertension and Mesenteric Artery Dysfunction in Two Generations of Sprague-Dawley Rat Offspring1
Biology of Reproduction
2006
68
28
Thyrotropin-releasing hormone increases GABA release in rat hippocampus
Journal of Physiology
2006
64
29
Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-α-mediated neurotoxicity
Neurobiology of Disease
2007
64
30
Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice
Mechanisms of Ageing and Development
2005
63
31
Noradrenergic Depression of Neuronal Excitability in the Entorhinal Cortex via Activation of TREK-2 K+ Channels
Journal of Biological Chemistry
2009
62
32
Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production
Neurobiology of Aging
2013
60
33
Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels
Molecular and Cellular Neurosciences
2008
58
34
α1A- and α1B-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse
Brain Research
2009
58
35
Uptake and metabolism of plasma-derived erucic acid by rat brain
Journal of Lipid Research
2006
57
36
Deferiprone Reduces Amyloid-β and Tau Phosphorylation Levels but not Reactive Oxygen Species Generation in Hippocampus of Rabbits Fed a Cholesterol-Enriched Diet
Journal of Alzheimer's Disease
2012
57
37
Salsolinol, a dopamine-derived tetrahydroisoquinoline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein
Brain Research
2004
56
38
Adrenergic Facilitation of GABAergic Transmission in Rat Entorhinal Cortex
Journal of Neurophysiology
2007
55
39
Acetate supplementation attenuates lipopolysaccharide‐induced neuroinflammation
Journal of Neurochemistry
2011
55
40
Serotonin Inhibits Neuronal Excitability by Activating Two-Pore Domain K+ Channels in the Entorhinal Cortex
Molecular Pharmacology
2007
53
41
Long-Term Depression in Identified Stellate Neurons of Juvenile Rat Entorhinal Cortex
Journal of Neurophysiology
2007
51
42
A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2012
49
43
Long-living growth hormone receptor knockout mice: Potential mechanisms of altered stress resistance
Experimental Gerontology
2009
48
44
Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism
Cancer Detection and Prevention
2005
47
45
Bidirectional modulation of GABAergic transmission by cholecystokinin in hippocampal dentate gyrus granule cells of juvenile rats
Journal of Physiology
2006
47
46
Bovine muscle n−3 fatty acid content is increased with flaxseed feeding
Lipids
2006
47
47
Melatonin protects SK-N-SH neuroblastoma cells from amphetamine-induced neurotoxicity
Journal of Pineal Research
2007
46
48
Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons
Life Sciences
2012
46
49
Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol
Cellular Signalling
2012
46
50
Leptin signaling and Alzheimer's disease
American Journal of Neurodegenerative Disease
2012
45
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