| # | Title | Journal | Year | Citations |
|---|
| 1 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 2 | Proposed minimum reporting standards for chemical analysis | Metabolomics | 2007 | 3,589 |
| 3 | The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma | New England Journal of Medicine | 2003 | 1,368 |
| 4 | A Randomized Trial of Telemedicine-based Collaborative Care for Depression | Journal of General Internal Medicine | 2007 | 521 |
| 5 | Behavioral and neuroeconomics of drug addiction: Competing neural systems and temporal discounting processes | Drug and Alcohol Dependence | 2007 | 490 |
| 6 | Is There Hardening of the Heart During Medical School? | Academic Medicine | 2008 | 425 |
| 7 | Increasing Prevalence of Medically Complex Children in US Hospitals | Pediatrics | 2010 | 344 |
| 8 | Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans* | Clinical Pharmacology and Therapeutics | 2002 | 331 |
| 9 | The cannabis withdrawal syndrome | Current Opinion in Psychiatry | 2006 | 304 |
| 10 | Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis | Journal of Biological Chemistry | 2004 | 296 |
| 11 | The Association of Child and Household Food Insecurity With Childhood Overweight Status | Pediatrics | 2006 | 281 |
| 12 | Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes | Journal of Pharmacology and Experimental Therapeutics | 2005 | 273 |
| 13 | Risks for opioid abuse and dependence among recipients of chronic opioid therapy: Results from the TROUP Study | Drug and Alcohol Dependence | 2010 | 271 |
| 14 | Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition | Drug Metabolism Reviews | 2004 | 260 |
| 15 | Practice-Based Versus Telemedicine-Based Collaborative Care for Depression in Rural Federally Qualified Health Centers: A Pragmatic Randomized Comparative Effectiveness Trial | American Journal of Psychiatry | 2013 | 241 |
| 16 | Dialectical Behavior Therapy Is Effective for the Treatment of Suicidal Behavior: A Meta-Analysis | Behavior Therapy | 2019 | 234 |
| 17 | Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project | Genetics in Medicine | 2008 | 232 |
| 18 | In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes | Clinical Pharmacology and Therapeutics | 2005 | 231 |
| 19 | Trends in Use of Opioids for Chronic Noncancer Pain Among Individuals With Mental Health and Substance Use Disorders: The TROUP Study | Clinical Journal of Pain | 2010 | 227 |
| 20 | Delay Discounting, Locus of Control, and Cognitive Impulsiveness Independently Predict Tobacco Dependence Treatment Outcomes in a Highly Dependent, Lower Socioeconomic Group of Smokers | American Journal on Addictions | 2012 | 219 |
| 21 | Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly | Drugs and Aging | 2005 | 210 |
| 22 | Maternal Smoking and Congenital Heart Defects | Pediatrics | 2008 | 202 |
| 23 | A Legacy of Microneurosurgery: Memoirs, Lessons, and Axioms | Neurosurgery | 1999 | 193 |
| 24 | Hypercapnia during the first 3 days of life is associated with severe intraventricular hemorrhage in very low birth weight infants | Journal of Perinatology | 2006 | 191 |
| 25 | Computerized behavior therapy for opioid-dependent outpatients: A randomized controlled trial. | Experimental and Clinical Psychopharmacology | 2008 | 188 |
| 26 | The national birth defects prevention study: A review of the methods | Birth Defects Research Part A: Clinical and Molecular Teratology | 2015 | 188 |
| 27 | NIH Consensus Development Conference Statement: Inhaled Nitric-Oxide Therapy for Premature Infants | Pediatrics | 2011 | 183 |
| 28 | The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset | Journal of Neurochemistry | 2006 | 180 |
| 29 | The Effects of Hypercapnia on Cerebral Autoregulation in Ventilated Very Low Birth Weight Infants | Pediatric Research | 2005 | 170 |
| 30 | Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands | Drug Metabolism and Disposition | 2012 | 167 |
| 31 | Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis | Neurobiology of Disease | 2006 | 165 |
| 32 | Impact of Prenatal and/or Postnatal Growth Problems in Low Birth Weight Preterm Infants on School-Age Outcomes: An 8-Year Longitudinal Evaluation | Pediatrics | 2006 | 160 |
| 33 | Plasma serotonin levels and the platelet serotonin transporter | Journal of Neurochemistry | 2007 | 158 |
| 34 | Chlamydia trachomatis Infections in Neonates and Young Children | Seminars in Pediatric Infectious Diseases | 2005 | 156 |
| 35 | Telepsychiatry integration of mental health services into rural primary care settings | International Review of Psychiatry | 2015 | 154 |
| 36 | Decoding the epitranscriptional landscape from native RNA sequences | Nucleic Acids Research | 2021 | 149 |
| 37 | Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea | Molecular Nutrition and Food Research | 2008 | 147 |
| 38 | The Pediatric Quality of Life Inventory: An Evaluation of Its Reliability and Validity for Children With Traumatic Brain Injury | Archives of Physical Medicine and Rehabilitation | 2005 | 146 |
| 39 | Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: epidemiological and toxicological evidence | Journal of Exposure Science and Environmental Epidemiology | 2019 | 144 |
| 40 | Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism , | American Journal of Clinical Nutrition | 2005 | 143 |
| 41 | Delay discounting rates: A strong prognostic indicator of smoking relapse | Addictive Behaviors | 2014 | 141 |
| 42 | One-way Cross-talk between p38MAPK and p42/44MAPK | Journal of Biological Chemistry | 1999 | 139 |
| 43 | Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine | Analytical Chemistry | 2011 | 138 |
| 44 | In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity | Neuropsychopharmacology | 2013 | 136 |
| 45 | Unstable Housing and Caregiver and Child Health in Renter Families | Pediatrics | 2018 | 136 |
| 46 | Violent Reinjury and Mortality Among Youth Seeking Emergency Department Care for Assault-Related Injury | JAMA Pediatrics | 2015 | 134 |
| 47 | Manganese porphyrin given at symptom onset markedly extends survival of ALS mice | Annals of Neurology | 2005 | 131 |
| 48 | Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects | Human Genetics | 2009 | 125 |
| 49 | Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors | Journal of Pharmacology and Experimental Therapeutics | 2005 | 124 |
| 50 | Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics | Molecular Nutrition and Food Research | 2008 | 124 |
