Oligonucleotides

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#	Title	Journal	Year	Citations
1	Morpholino Antisense Oligomers: Design, Preparation, and Properties	Oligonucleotides	1997	906
2	Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing	Oligonucleotides	2003	419
3	Phosphorothioate Oligodeoxynucleotides: What Is Their Origin and What Is Unique About Them?	Oligonucleotides	2000	331
4	Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment	Oligonucleotides	2002	241
5	CpG Motif Identification for Veterinary and Laboratory Species Demonstrates That Sequence Recognition Is Highly Conserved	Oligonucleotides	2001	202
6	Resistance of Morpholino Phosphorodiamidate Oligomers to Enzymatic Degradation	Oligonucleotides	1996	199
7	Cell-Dependent Differential Cellular Uptake of PNA, Peptides, and PNA-Peptide Conjugates	Oligonucleotides	2002	196
8	Oligonucleotide Conjugates as Potential Antisense Drugs with Improved Uptake, Biodistribution, Targeted Delivery, and Mechanism of Action	Oligonucleotides	2002	170
9	Comparison of the Suppressive Effects of Antisense Oligonucleotides and siRNAs Directed Against the Same Targets in Mammalian Cells	Oligonucleotides	2003	166
10	Morpholino and Phosphorothioate Antisense Oligomers Compared in Cell-Free and In-Cell Systems	Oligonucleotides	1997	151
11	A Specificity Comparison of Four Antisense Types: Morpholino, 2′-O-Methyl RNA, DNA, and Phosphorothioate DNA	Oligonucleotides	1997	137
12	Cellular Uptake, Distribution, and Stability of 10-23 Deoxyribozymes	Oligonucleotides	2002	120
13	Inhibition of Coagulation by a Phosphorothioate Oligonucleotide	Oligonucleotides	1997	108
14	An Overview of Progress in Antisense Therapeutics	Oligonucleotides	1998	106
15	Progress in Developments of Triplex-Based Strategies	Oligonucleotides	1997	105
16	Progress in Developing PNA as a Gene-Targeted Drug	Oligonucleotides	1997	102
17	CpG Stimulation of Primary Mouse B Cells Is Blocked by Inhibitory Oligodeoxyribonucleotides at a Site Proximal to NF-κB Activation	Oligonucleotides	2001	101
18	Effects on RNA Interference in Gene Expression (RNAi) in Cultured Mammalian Cells of Mismatches and the Introduction of Chemical Modifications at the 3′-Ends of siRNAs	Oligonucleotides	2002	99
19	Spongelike Alginate Nanoparticles as a New Potential System for the Delivery of Antisense Oligonucleotides	Oligonucleotides	1999	94
20	Pattern and Kinetics of Cytokine Production Following Administration of Phosphorothioate Oligonucleotides in Mice	Oligonucleotides	1997	93
21	Molecular Mechanisms of Antisense Drugs: RNase H	Oligonucleotides	1998	92
22	A Simple Method for Delivering Morpholino Antisense Oligos into the Cytoplasm of Cells	Oligonucleotides	1996	91
23	Heterocyclic Modifications of Oligonucleotides and Antisense Technology	Oligonucleotides	2000	89
24	HIV Tat Peptide Enhances Cellular Delivery of Antisense Morpholino Oligomers	Oligonucleotides	2003	86
25	Vitravene™—Another Piece in the Mosaic	Oligonucleotides	1998	84
26	Pharmacokinetics and Tissue Distribution of a Peptide Nucleic Acid After Intravenous Administration	Oligonucleotides	2002	84
27	Oligodeoxynucleotide Modifications Determine the Magnitude of B Cell Stimulation by CpG Motifs	Oligonucleotides	1996	81
28	Stability of Stereoregular Oligo(nucleoside Phosphorothioate)s in Human Plasma: Diastereoselectivity of Plasma 3‵-Exonuclease	Oligonucleotides	1997	81
29	Reduction of Antigen Expression from DNA Vaccines by Coadministered Oligodeoxynucleotides	Oligonucleotides	1998	81
30	Evaluation of the Toxicity of ISIS 2302, a Phosphorothioate Oligonucleotide, in a 4-Week Study in CD-1 Mice	Oligonucleotides	1997	78
31	Antisense Morpholino Oligonucleotide Analog Induces Missplicing of C-mycmRNA	Oligonucleotides	1999	76
32	Mixed Backbone Oligonucleotides: Improvement in Oligonucleotide-induced Toxicity In Vivo	Oligonucleotides	1998	75
33	Therapeutic Applications of CpG-Containing Oligodeoxynucleotides	Oligonucleotides	1998	69
34	Oligonucleotide Inhibitors of P-Selectin-Dependent Neutrophil-Platelet Adhesion	Oligonucleotides	1998	68
35	Anti-L-Selectin Aptamers: Binding Characteristics, Pharmacokinetic Parameters, and Activity Against an Intravascular TargetIn Vivo	Oligonucleotides	2000	68
36	Polyethylenimine but Not Cationic Lipid Improves Antisense Activity of 3′-Capped Phosphodiester Oligonucleotides	Oligonucleotides	1999	64
37	ADAM17 but Not ADAM10 Mediates Tumor Necrosis Factor-α and L-Selectin Shedding from Leukocyte Membranes	Oligonucleotides	2001	60
38	Delivery of Antisense Oligonucleotide to the Cornea by Iontophoresis	Oligonucleotides	2003	60
39	Downregulation of the CCR5 β-Chemokine Receptor and Inhibition of HIV-1 Infection by Stable VA1-Ribozyme Chimeric Transcripts	Oligonucleotides	2000	59
40	Highly Immunostimulatory CpG-Free Oligodeoxynucleotides for Activation of Human Leukocytes	Oligonucleotides	2002	59
41	Antiproliferative Effects of Steric Blocking Phosphorodiamidate Morpholino Antisense Agents Directed against c-myc	Oligonucleotides	2000	58
42	PNA Beacons for Duplex DNA	Oligonucleotides	2001	58
43	From Bugs to Drugs: Therapeutic Immunomodulation with Oligodeoxynucleotides Containing CpG Sequences from Bacterial DNA	Oligonucleotides	2001	56
44	Cationic Polyhexylcyanoacrylate Nanoparticles as Carriers for Antisense Oligonucleotides	Oligonucleotides	1997	55
45	Pharmacokinetic and Toxicity Profile of a Phosphorothioate Oligonucleotide Following Inhalation Delivery to Lung in Mice	Oligonucleotides	2000	55
46	Identification and Characterization of Second-Generation Antisense Oligonucleotides	Oligonucleotides	1997	54
47	Molecular Cloning and Expression of cDNA for Human RNase H	Oligonucleotides	1998	54
48	Boranophosphates Support the RNase H Cleavage of Polyribonucleotides	Oligonucleotides	1999	53
49	The Sequence-Specific Cleavage of RNA by Artificial Chemical Ribonucleases	Oligonucleotides	1997	52
50	Characterization and Modulation of Immune Stimulation by Modified Oligonucleotides	Oligonucleotides	1997	51

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