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348(top 50%)
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23(top 20%)
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Top Articles

#TitleJournalYearCitations
1Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradationRSC Chemical Biology2021118
2Cyclic peptide drugs approved in the last two decades (2001–2021)RSC Chemical Biology2022114
3Fragment-based covalent ligand discoveryRSC Chemical Biology202165
4Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategiesRSC Chemical Biology202155
5Transfer hydrogenation catalysis in cellsRSC Chemical Biology202150
6Matters of class: coming of age of class III and IV lanthipeptidesRSC Chemical Biology202047
7Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistryRSC Chemical Biology202043
8Substrate inhibition by the blockage of product release and its control by tunnel engineeringRSC Chemical Biology202143
9Recent development of near-infrared photoacoustic probes based on small-molecule organic dyeRSC Chemical Biology202140
10DNA folds threaten genetic stability and can be leveraged for chemotherapyRSC Chemical Biology202139
11Activatable cell-penetrating peptides: 15 years of researchRSC Chemical Biology202038
12Modified internucleoside linkages for nuclease-resistant oligonucleotidesRSC Chemical Biology202135
1319F NMR viewed through two different lenses: ligand-observed and protein-observed19F NMR applications for fragment-based drug discoveryRSC Chemical Biology202135
14Enzymatic strategies for asymmetric synthesisRSC Chemical Biology202134
15Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)RSC Chemical Biology202133
16Laccase-mediated synthesis of bioactive natural products and their analoguesRSC Chemical Biology202233
17A decade of alkyne-tag Raman imaging (ATRI): applications in biological systemsRSC Chemical Biology202132
18Computational analyses of mechanism of action (MoA): data, methods and integrationRSC Chemical Biology202232
19Quantification and mapping of DNA modificationsRSC Chemical Biology202131
20Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteinsRSC Chemical Biology202131
21Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activityRSC Chemical Biology202130
22Biosynthesis of alkyne-containing natural productsRSC Chemical Biology202129
23Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistanceRSC Chemical Biology202028
24A peptidic inhibitor for PD-1 palmitoylation targets its expression and functionsRSC Chemical Biology202126
25Targeting the RNA demethylase FTO for cancer therapyRSC Chemical Biology202126
26Structural motifs and intramolecular interactions in non-canonical G-quadruplexesRSC Chemical Biology202126
27A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocksRSC Chemical Biology202124
28Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migrationRSC Chemical Biology202123
29Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16RSC Chemical Biology202223
30Cereblon covalent modulation through structure-based design of histidine targeting chemical probesRSC Chemical Biology202223
31Dehydroamino acid chemical biology: an example of functional group interconversion on proteinsRSC Chemical Biology202022
32Tools for functional dissection of site-specific O-GlcNAcylationRSC Chemical Biology202022
33Natural Trojan horse inhibitors of aminoacyl-tRNA synthetasesRSC Chemical Biology202122
34Macrocyclic DNA-encoded chemical libraries: a historical perspectiveRSC Chemical Biology202222
35Chemical methods for protein site-specific ubiquitinationRSC Chemical Biology202121
36Strategies to promote permeation and vectorization, and reduce cytotoxicity of metal complex luminophores for bioimaging and intracellular sensingRSC Chemical Biology202121
37Lysine methyltransferase inhibitors: where we are nowRSC Chemical Biology202221
38A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitorRSC Chemical Biology202020
39Faster, better, and cheaper: harnessing microfluidics and mass spectrometry for biotechnologyRSC Chemical Biology202120
40Nanobodies asin vivo, non-invasive, imaging agentsRSC Chemical Biology202120
41Advances in single-cell multi-omics profilingRSC Chemical Biology202120
42Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry?RSC Chemical Biology202020
43Members of the Legionella pneumophila Sde family target tyrosine residues for phosphoribosyl-linked ubiquitinationRSC Chemical Biology202119
44Modulators of protein–protein interactions as antimicrobial agentsRSC Chemical Biology202119
45Harnessing cyclotides to design and develop novel peptide GPCR ligandsRSC Chemical Biology202018
46Development and biological applications of sulfur–triazole exchange (SuTEx) chemistryRSC Chemical Biology202118
47Self-cleaving ribozymes: substrate specificity and synthetic biology applicationsRSC Chemical Biology202118
48Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesisRSC Chemical Biology202017
49Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agentsRSC Chemical Biology202016
50Glycan–protein interactions determine kinetics of N-glycan remodelingRSC Chemical Biology202116