| 1 | Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals | Cell Reports Medicine | 2021 | 450 |
| 2 | Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases | Cell Reports Medicine | 2021 | 367 |
| 3 | Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients | Cell Reports Medicine | 2020 | 347 |
| 4 | Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells | Cell Reports Medicine | 2021 | 308 |
| 5 | The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19 | Cell Reports Medicine | 2022 | 302 |
| 6 | Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device | Cell Reports Medicine | 2021 | 193 |
| 7 | Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions | Cell Reports Medicine | 2021 | 178 |
| 8 | The gut microbiota-immune-brain axis: Therapeutic implications | Cell Reports Medicine | 2025 | 161 |
| 9 | Artificial intelligence in diabetes management: Advancements, opportunities, and challenges | Cell Reports Medicine | 2023 | 154 |
| 10 | Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults | Cell Reports Medicine | 2022 | 153 |
| 11 | Virtual and augmented reality for biomedical applications | Cell Reports Medicine | 2021 | 152 |
| 12 | Deep generative molecular design reshapes drug discovery | Cell Reports Medicine | 2022 | 152 |
| 13 | Delivery Mode Affects Stability of Early Infant Gut Microbiota | Cell Reports Medicine | 2020 | 150 |
| 14 | Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study | Cell Reports Medicine | 2020 | 144 |
| 15 | SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential | Cell Reports Medicine | 2020 | 140 |
| 16 | Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells | Cell Reports Medicine | 2020 | 135 |
| 17 | Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19 | Cell Reports Medicine | 2020 | 132 |
| 18 | Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients | Cell Reports Medicine | 2020 | 131 |
| 19 | Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms | Cell Reports Medicine | 2021 | 131 |
| 20 | Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease | Cell Reports Medicine | 2020 | 130 |
| 21 | Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses | Cell Reports Medicine | 2021 | 128 |
| 22 | Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease | Cell Reports Medicine | 2021 | 128 |
| 23 | Brief structured respiration practices enhance mood and reduce physiological arousal | Cell Reports Medicine | 2023 | 127 |
| 24 | Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study | Cell Reports Medicine | 2023 | 121 |
| 25 | Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset | Cell Reports Medicine | 2021 | 119 |
| 26 | An Automated Organoid Platform with Inter-organoid Homogeneity and Inter-patient Heterogeneity | Cell Reports Medicine | 2020 | 119 |
| 27 | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring | Cell Reports Medicine | 2023 | 119 |
| 28 | CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17 | Cell Reports Medicine | 2020 | 118 |
| 29 | Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA | Cell Reports Medicine | 2022 | 116 |
| 30 | Radiomics in breast cancer: Current advances and future directions | Cell Reports Medicine | 2024 | 112 |
| 31 | Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer | Cell Reports Medicine | 2020 | 110 |
| 32 | The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC) | Cell Reports Medicine | 2021 | 110 |
| 33 | Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer | Cell Reports Medicine | 2020 | 107 |
| 34 | Integrated immune dynamics define correlates of COVID-19 severity and antibody responses | Cell Reports Medicine | 2021 | 107 |
| 35 | Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease | Cell Reports Medicine | 2022 | 106 |
| 36 | Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer’s-type dementia | Cell Reports Medicine | 2021 | 104 |
| 37 | Regorafenib plus toripalimab in patients with metastatic colorectal cancer: a phase Ib/II clinical trial and gut microbiome analysis | Cell Reports Medicine | 2021 | 102 |
| 38 | Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters | Cell Reports Medicine | 2020 | 101 |
| 39 | Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses | Cell Reports Medicine | 2023 | 101 |
| 40 | Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases | Cell Reports Medicine | 2023 | 100 |
| 41 | A distinct innate immune signature marks progression from mild to severe COVID-19 | Cell Reports Medicine | 2021 | 97 |
| 42 | Artificial intelligence in ophthalmology: The path to the real-world clinic | Cell Reports Medicine | 2023 | 97 |
| 43 | METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy | Cell Reports Medicine | 2023 | 97 |
| 44 | Federated machine learning in healthcare: A systematic review on clinical applications and technical architecture | Cell Reports Medicine | 2024 | 96 |
| 45 | Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting | Cell Reports Medicine | 2021 | 95 |
| 46 | Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine | Cell Reports Medicine | 2021 | 95 |
| 47 | Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination | Cell Reports Medicine | 2021 | 95 |
| 48 | AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients | Cell Reports Medicine | 2020 | 93 |
| 49 | Current understanding of the intratumoral microbiome in various tumors | Cell Reports Medicine | 2023 | 90 |
| 50 | Predicting endometrial cancer subtypes and molecular features from histopathology images using multi-resolution deep learning models | Cell Reports Medicine | 2021 | 89 |