| 1 | DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges | ACS Pharmacology and Translational Science | 2021 | 211 |
| 2 | Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics | ACS Pharmacology and Translational Science | 2021 | 198 |
| 3 | Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors | ACS Pharmacology and Translational Science | 2020 | 193 |
| 4 | Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening | ACS Pharmacology and Translational Science | 2020 | 167 |
| 5 | Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials | ACS Pharmacology and Translational Science | 2023 | 138 |
| 6 | DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDsin Vitroandin Vivo | ACS Pharmacology and Translational Science | 2018 | 132 |
| 7 | Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects | ACS Pharmacology and Translational Science | 2021 | 129 |
| 8 | Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen | ACS Pharmacology and Translational Science | 2021 | 123 |
| 9 | Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review | ACS Pharmacology and Translational Science | 2021 | 120 |
| 10 | Empagliflozin and Doxorubicin Synergistically Inhibit the Survival of Triple-Negative Breast Cancer Cells via Interfering with the mTOR Pathway and Inhibition of Calmodulin: In Vitro and Molecular Docking Studies | ACS Pharmacology and Translational Science | 2020 | 105 |
| 11 | Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination | ACS Pharmacology and Translational Science | 2018 | 99 |
| 12 | New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery | ACS Pharmacology and Translational Science | 2020 | 97 |
| 13 | Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers | ACS Pharmacology and Translational Science | 2021 | 91 |
| 14 | Rules of Engagement: GPCRs and G Proteins | ACS Pharmacology and Translational Science | 2018 | 90 |
| 15 | An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19 | ACS Pharmacology and Translational Science | 2020 | 87 |
| 16 | Acute and Sustained Reductions in Loss of Meaning and Suicidal Ideation Following Psilocybin-Assisted Psychotherapy for Psychiatric and Existential Distress in Life-Threatening Cancer | ACS Pharmacology and Translational Science | 2021 | 83 |
| 17 | Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles | ACS Pharmacology and Translational Science | 2020 | 82 |
| 18 | Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth | ACS Pharmacology and Translational Science | 2021 | 82 |
| 19 | High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing | ACS Pharmacology and Translational Science | 2018 | 76 |
| 20 | Investigation of the Structure–Activity Relationships of Psilocybin Analogues | ACS Pharmacology and Translational Science | 2021 | 74 |
| 21 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir | ACS Pharmacology and Translational Science | 2021 | 73 |
| 22 | Chronic Wound Healing Models | ACS Pharmacology and Translational Science | 2023 | 71 |
| 23 | Cannabinoid Receptor 2 (CB2) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes | ACS Pharmacology and Translational Science | 2019 | 67 |
| 24 | Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins | ACS Pharmacology and Translational Science | 2020 | 67 |
| 25 | Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin | ACS Pharmacology and Translational Science | 2018 | 66 |
| 26 | Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay | ACS Pharmacology and Translational Science | 2020 | 65 |
| 27 | Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities | ACS Pharmacology and Translational Science | 2022 | 64 |
| 28 | Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice | ACS Pharmacology and Translational Science | 2022 | 64 |
| 29 | Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted
In Vivo
Chemistry | ACS Pharmacology and Translational Science | 2021 | 63 |
| 30 | Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next? | ACS Pharmacology and Translational Science | 2021 | 63 |
| 31 | Naturalistic Use of Mescaline Is Associated with Self-Reported Psychiatric Improvements and Enduring Positive Life Changes | ACS Pharmacology and Translational Science | 2021 | 61 |
| 32 | Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N6-Methyladenosine-Modified RNAs | ACS Pharmacology and Translational Science | 2022 | 60 |
| 33 | Metabolic Efficacy of Phosphate Prodrugs and the Remdesivir Paradigm | ACS Pharmacology and Translational Science | 2020 | 57 |
| 34 | G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications | ACS Pharmacology and Translational Science | 2020 | 57 |
| 35 | Association of COVID-19 with Comorbidities: An Update | ACS Pharmacology and Translational Science | 2023 | 57 |
| 36 | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment | ACS Pharmacology and Translational Science | 2021 | 56 |
| 37 | Therapeutic Potential of Aptamer–Protein Interactions | ACS Pharmacology and Translational Science | 2022 | 55 |
| 38 | Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds | ACS Pharmacology and Translational Science | 2020 | 54 |
| 39 | Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy | ACS Pharmacology and Translational Science | 2020 | 53 |
| 40 | Therapeutic Potential of Lipoxin A4 in Chronic Inflammation: Focus on Cardiometabolic Disease | ACS Pharmacology and Translational Science | 2020 | 50 |
| 41 | The Emerging Role of Adhesion GPCRs in Cancer | ACS Pharmacology and Translational Science | 2020 | 50 |
| 42 | The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease | ACS Pharmacology and Translational Science | 2020 | 48 |
| 43 | Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir | ACS Pharmacology and Translational Science | 2021 | 48 |
| 44 | Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB1R) Antagonist | ACS Pharmacology and Translational Science | 2021 | 45 |
| 45 | On the Relationship between Classic Psychedelics and Suicidality: A Systematic Review | ACS Pharmacology and Translational Science | 2021 | 44 |
| 46 | SARS-CoV-2 Receptor ACE2 Is Enriched in a Subpopulation of Mouse Tongue Epithelial Cells in Nongustatory Papillae but Not in Taste Buds or Embryonic Oral Epithelium | ACS Pharmacology and Translational Science | 2020 | 43 |
| 47 | Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors | ACS Pharmacology and Translational Science | 2020 | 43 |
| 48 | Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors | ACS Pharmacology and Translational Science | 2020 | 43 |
| 49 | A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics | ACS Pharmacology and Translational Science | 2021 | 43 |
| 50 | Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19 | ACS Pharmacology and Translational Science | 2021 | 43 |