Central Nervous System Agents in Medicinal Chemistry

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#	Title	Journal	Year	Citations
1	Astrocytes: Targets for Neuroprotection in Stroke	Central Nervous System Agents in Medicinal Chemistry	2011	257
2	Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha	Central Nervous System Agents in Medicinal Chemistry	2010	122
3	Mechanisms and Treatment of Neuropathic Pain	Central Nervous System Agents in Medicinal Chemistry	2009	114
4	Estradiol, Dopamine and Motivation	Central Nervous System Agents in Medicinal Chemistry	2015	114
5	Sigma-1 Receptor Chaperones and Diseases	Central Nervous System Agents in Medicinal Chemistry	2009	109
6	p38 MAP Kinase Inhibitors as Potential Therapeutic Drugs for Neural Diseases	Central Nervous System Agents in Medicinal Chemistry	2011	101
7	The Dual Role of Serotonin in Defense and the Mode of Action of Antidepressants on Generalized Anxiety and Panic Disorders	Central Nervous System Agents in Medicinal Chemistry	2010	100
8	Elucidation of Pathophysiology and Treatment of Neuropathic Pain	Central Nervous System Agents in Medicinal Chemistry	2012	97
9	Sigma-1 Receptors and Selective Serotonin Reuptake Inhibitors: Clinical Implications of their Relationship	Central Nervous System Agents in Medicinal Chemistry	2009	94
10	Selective Sigma-1 (σ1) Receptor Antagonists: Emerging Target for the Treatment of Neuropathic Pain	Central Nervous System Agents in Medicinal Chemistry	2009	82
11	Choline Nutrition Programs Brain Development Via DNA and Histone Methylation	Central Nervous System Agents in Medicinal Chemistry	2012	75
12	Neuroprotective Actions of Flavones and Flavonols: Mechanisms and Relationship to Flavonoid Structural Features	Central Nervous System Agents in Medicinal Chemistry	2013	73
13	A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and Alzheimers Disease	Central Nervous System Agents in Medicinal Chemistry	2010	72
14	Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms	Central Nervous System Agents in Medicinal Chemistry	2011	70
15	An Introduction to the Nutrition and Metabolism of Choline	Central Nervous System Agents in Medicinal Chemistry	2012	70
16	Anti-Inflammatory Effects of Antidepressants: Possibilities for Preventives Against Alzheimers Disease	Central Nervous System Agents in Medicinal Chemistry	2009	67
17	Development of Molecular Probes for Imaging Sigma-2 Receptors in Vitro and in Vivo	Central Nervous System Agents in Medicinal Chemistry	2009	66
18	The Doublecortin Gene Family and Disorders of Neuronal Structure	Central Nervous System Agents in Medicinal Chemistry	2010	59
19	Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review	Central Nervous System Agents in Medicinal Chemistry	2016	59
20	Basic Sleep Mechanisms: An Integrative Review	Central Nervous System Agents in Medicinal Chemistry	2012	55
21	Neuroprotective Actions of Flavones and Flavonols: Mechanisms and Relationship to Flavonoid Structural Features	Central Nervous System Agents in Medicinal Chemistry	2013	54
22	Emerging Evidence for the Role of Neurotransmitters in the Modulation of T Cell Responses to Cognate Ligands	Central Nervous System Agents in Medicinal Chemistry	2010	49
23	Imaging of Sigma1 Receptors in the Human Brain Using PET and [11C]SA4503	Central Nervous System Agents in Medicinal Chemistry	2009	49
24	New Insight into the Therapeutic Role of 5-HT1A Receptors in Central Nervous System Disorders	Central Nervous System Agents in Medicinal Chemistry	2010	48
25	Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease	Central Nervous System Agents in Medicinal Chemistry	2019	48
26	Melatonin and Synthetic Melatonergic Agonists: Actions and Metabolism in the Central Nervous System	Central Nervous System Agents in Medicinal Chemistry	2012	46
27	The Glutathione System and its Regulation by Neurohormone Melatonin in the Central Nervous System	Central Nervous System Agents in Medicinal Chemistry	2010	44
28	Glucose Transporters Regulation on Ischemic Brain: Possible Role as Therapeutic Target	Central Nervous System Agents in Medicinal Chemistry	2010	44
29	1,2,4-Triazole Derivatives as Potential Scaffold for Anticonvulsant Activity	Central Nervous System Agents in Medicinal Chemistry	2015	43
30	PET Tracers for Serotonin Receptors and Their Applications	Central Nervous System Agents in Medicinal Chemistry	2015	43
31	Recent Findings in Melatonin Research and Their Relevance to the CNS	Central Nervous System Agents in Medicinal Chemistry	2018	42
32	In Vivo Experimental Models of Epilepsy	Central Nervous System Agents in Medicinal Chemistry	2010	41
33	Targeted Drug Delivery to Central Nervous System (CNS) for the Treatment of Neurodegenerative Disorders: Trends and Advances	Central Nervous System Agents in Medicinal Chemistry	2014	41
34	The Ubiquitous Choline Transporter SLC44A1	Central Nervous System Agents in Medicinal Chemistry	2012	40
35	Neurosteroids in the Brain Neuron: Biosynthesis, Action and Medicinal Impact on Neurodegenerative Disease	Central Nervous System Agents in Medicinal Chemistry	2006	39
36	Structural Variation of Chondroitin Sulfate and Its Roles in the Central Nervous System	Central Nervous System Agents in Medicinal Chemistry	2010	39
37	Pyrazoline: A Promising Scaffold for the Inhibition of Monoamine Oxidase	Central Nervous System Agents in Medicinal Chemistry	2014	39
38	The Emerging Role of the Endocannabinoid System in the Sleep-Wake Cycle Modulation	Central Nervous System Agents in Medicinal Chemistry	2011	37
39	Are Circulating Monocytes as Microglia Orthologues Appropriate Biomarker Targets for Neuronal Diseases? (Supplementry Table)	Central Nervous System Agents in Medicinal Chemistry	2009	36
40	Novel Agents in CNS Myeloma Treatment	Central Nervous System Agents in Medicinal Chemistry	2014	34
41	Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity	Central Nervous System Agents in Medicinal Chemistry	2012	32
42	Effect of Withania somnifera Supplementation on Rotenone-Induced Oxidative Damage in Cerebellum and Striatum of the Male Mice Brain	Central Nervous System Agents in Medicinal Chemistry	2013	32
43	Beyond Mitochondria, What Would be the Energy Source of the Cell?	Central Nervous System Agents in Medicinal Chemistry	2015	32
44	Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review	Central Nervous System Agents in Medicinal Chemistry	2019	32
45	Recent Advances in the Treatment of Amyotrophic Lateral Sclerosis. Emphasis on Kynurenine Pathway Inhibitors	Central Nervous System Agents in Medicinal Chemistry	2009	31
46	The Protective Role of Heme Oxygenase-1 in Cerebral Ischemia	Central Nervous System Agents in Medicinal Chemistry	2010	31
47	Neuromyelitis Optica (NMO IgG+) and Genetic Susceptibility, Potential Ethnic Influences	Central Nervous System Agents in Medicinal Chemistry	2018	31
48	A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands	Central Nervous System Agents in Medicinal Chemistry	2009	31
49	Role of the α7 Nicotinic Acetylcholine Receptor and RIC-3 in the Cholinergic Anti-inflammatory Pathway	Central Nervous System Agents in Medicinal Chemistry	2017	30
50	Transcranial Magnetic Stimulation in Clinical Pharmacology	Central Nervous System Agents in Medicinal Chemistry	2008	29

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