Nature Metabolism

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#	Title	Journal	Year	Citations
1	We need to talk about the Warburg effect	Nature Metabolism	2020	476
2	Skeletal muscle energy metabolism during exercise	Nature Metabolism	2020	464
3	Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities	Nature Metabolism	2020	411
4	SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas	Nature Metabolism	2021	378
5	Lactate: the ugly duckling of energy metabolism	Nature Metabolism	2020	371
6	Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo	Nature Metabolism	2022	356
7	Microbial regulation of organismal energy homeostasis	Nature Metabolism	2019	354
8	NAD+ homeostasis in health and disease	Nature Metabolism	2020	351
9	Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals	Nature Metabolism	2020	327
10	The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans	Nature Metabolism	2019	302
11	Leptin and the endocrine control of energy balance	Nature Metabolism	2019	295
12	Gut microbiome pattern reflects healthy ageing and predicts survival in humans	Nature Metabolism	2021	278
13	Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types	Nature Metabolism	2020	272
14	Coupling Krebs cycle metabolites to signalling in immunity and cancer	Nature Metabolism	2019	260
15	Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	Nature Metabolism	2021	259
16	Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism	Nature Metabolism	2021	250
17	Metabolic adaptation and maladaptation in adipose tissue	Nature Metabolism	2019	224
18	A metabolic handbook for the COVID-19 pandemic	Nature Metabolism	2020	223
19	A network of trans-cortical capillaries as mainstay for blood circulation in long bones	Nature Metabolism	2019	221
20	Metabolic signatures of cancer cells and stem cells	Nature Metabolism	2019	215
21	The metabolic roots of senescence: mechanisms and opportunities for intervention	Nature Metabolism	2021	211
22	NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism	Nature Metabolism	2019	209
23	Lipolysis: cellular mechanisms for lipid mobilization from fat stores	Nature Metabolism	2021	208
24	Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control	Nature Metabolism	2019	207
25	Cardiac glycosides are broad-spectrum senolytics	Nature Metabolism	2019	207
26	HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry	Nature Metabolism	2020	207
27	Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages	Nature Metabolism	2020	206
28	Molecular logic of mTORC1 signalling as a metabolic rheostat	Nature Metabolism	2019	197
29	Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function	Nature Metabolism	2020	194
30	Slc12a8 is a nicotinamide mononucleotide transporter	Nature Metabolism	2019	183
31	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss	Nature Metabolism	2019	181
32	Metabolic Messengers: adiponectin	Nature Metabolism	2019	177
33	Fructose stimulated de novo lipogenesis is promoted by inflammation	Nature Metabolism	2020	174
34	Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis	Nature Metabolism	2019	172
35	Metabolic and epigenetic regulation of T-cell exhaustion	Nature Metabolism	2020	167
36	Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages	Nature Metabolism	2020	163
37	m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes	Nature Metabolism	2019	158
38	Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy	Nature Metabolism	2019	158
39	Metabolic Messengers: ceramides	Nature Metabolism	2019	158
40	Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity	Nature Metabolism	2020	158
41	Inter-organ cross-talk in metabolic syndrome	Nature Metabolism	2019	157
42	CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	Nature Metabolism	2020	157
43	Metabolic Messengers: tumour necrosis factor	Nature Metabolism	2021	155
44	Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis	Nature Metabolism	2019	150
45	Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction	Nature Metabolism	2020	150
46	Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report	Nature Metabolism	2020	149
47	Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	Nature Metabolism	2021	147
48	Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis	Nature Metabolism	2019	141
49	Lipidomics needs more standardization	Nature Metabolism	2019	139
50	Exercise hormone irisin is a critical regulator of cognitive function	Nature Metabolism	2021	134

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